Conserved Protein Domain Family
PBP1_iGluR_AMPA_Like
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cd06383: PBP1_iGluR_AMPA_Like 
N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors
N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors. While this N-terminal domain belongs to the periplasmic-binding fold type 1 superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type 2. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. AMPA receptors consist of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important roles in mediating the rapid excitatory synaptic current.
Links
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Statistics
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PSSM-Id: 380606
Aligned: 7 rows
Threshold Bit Score: 573.227
Created: 17-May-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    ##      #                        
NP_608863  24 HQVFINEVDNEPAAKAVEVVLTYLKKni-ryGLSVQLDSIEANKS-DAKVLLEAICNKYATSie--kkQTPHLILDTTks 99  
AFP33229   24 NYLHVNDDKNSIPNKALKQVVADLSKq----GMIFDGVFKATANGsDVEALIDSMCLEYNTSid--enKKIHVVLDTTlq 97   migratory locust
AMA98202   25 NIMILNEERNWEASDSFRAAQEYFKQtp-tlGVEIGNLMNVTGNTtDAKTFLEMMCTEYNNSia--ekNPPHIVLDFTms 101  German cockroach
KOB78263   25 NILLINEENNALAEKAFEVAKEYVRRnp-tlGLAVEPTIVVGNRS-DAKVFLENVCRKYNDMls--akKSPHVVLDFTmt 100  winter moth
AKO90023   36 NLFIINDEENSLANNSVKNALMGIKDk---dKTVLGNVIVVQINGsDPRGSLDKVCAAWDPAvrdggpGVPDLVLDTTrs 112  Microplitis mediator
EFX86214   23 RVLLVYETNNVDADRAFTAVQSYLERtk-vqGLSLGNVTRVTLDStQKYLTVDDVCSVYDKSid--agTPPHIVLDLTws 99   common water flea
AAM47017   34 NIFMTYDEDNMLVKQSLDAAISYLEKntgegAMVDGKHIYAIPKGnDVEVTVNKSCDLMDEAid--agKPPHIVLDATtt 111  American lobster

Feature 1                     #                                                           #   
NP_608863 100 giasETVKSFTQALGLPTISASYGQQGdlrqwrdldeakqkYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMD 179 
AFP33229   98 dvssEAVKYFTRALELPTVSASCGQEGdlrywrnidkkqdkYMIQVMPPIDTIPEFIRSFCSAQNLTNAGILFDDTFIMD 177  migratory locust
AMA98202  102 svpsETAKSFTAALGLPTISTSFGQEGdlrqwrtlderekkYLIQIMPPADIIPEVIRSIVVSQNITNAGILFDDSIVMD 181  German cockroach
KOB78263  101 gvgsETVKSFTAALGLPTISGSFGQAGdlrqwrnlnvnqtkFLLQVMPPADVLPESIRAIVTKQEITNAAIIFDEFFVMD 180  winter moth
AKO90023  113 gfgaEAINSFTASIGVPTFSSQFGQKNdlrpwnnltpdqknYLVQIMPPADLIPNAIRQLCSQMNITNAAIIFDKGFVMD 192  Microplitis mediator
EFX86214  100 glssEVMKALTRNLGLPTISGSYGGIGdlkhwsnidgnqtkYLVQVMPPSDIIPQLVALITSMQNMTNAAILYDDSFDML 179  common water flea
AAM47017  112 gmisETIKSFTRALTLPTFSASYGQEGdirewrkltpseeeYLVQLMPPGDIIVQSIRDIVRTQNITNAGIIYDDTFVME 191  American lobster

Feature 1        #   #  ## #  ## #                                 #                          
NP_608863 180 HKYKSLLQNIQTRHVITAIAKDgkrerEEQIEKLRNLDINNFFILGTLQSIRMVLEs-vKPAYFERNFAWHAITQNEGEI 258 
AFP33229  178 HKYKSLLQNVPTRHIINEIKFQn---iANQLSTFKQREVFNYFILGRMDTVNKVLEaaaDMEFYGRQFGWYAITQDEGNP 254  migratory locust
AMA98202  182 HKYKSLLQNIPTRHMIVKVDQQg---pRAQLERMRSRDIFNYFIVGRMTTIKKVFDvayKKKYFMRQFAWHGITSDSGNV 258  German cockroach
KOB78263  181 HKYKSLLQNIPTRHVITPVKSFskdeiKTQLRSLRELDIVNFFVIGSLRTIKNVLDaadENQYFGRKTAWFALSLDKGDI 260  winter moth
AKO90023  193 HKYKSLLLNIPTRHVIVQSKIDtn-eiLNQLQRLRDLDIVNFFVLGEEVTLKSYLDaaeSKNFTGRKYGWYAFTMNENLD 271  Microplitis mediator
EFX86214  180 NKYKSLLKNRPIRHMFSKIETNi----NTQIRRLEDMDIVNFFVLGKIDRINQVLMsaaQENYFGKKYSWTAISKDGSAE 255  common water flea
AAM47017  192 HKYKSLLQNLPCRHIMTRVEATek-evRRQTKRLKDADIVNYFAVGSGDTISRILDaatANDMFGRKYAWYALSKDNQDI 270  American lobster

Feature 1                                                                                     
NP_608863 259 ss--qRDNATIMFMKPmay----tqYRDRLGLLRTTYnlneepqlSSAFYFDLALRSFLTIKEMLQSGAWPkdmeYLNCD 332 
AFP33229  255 scqkcGKGASVLHVKP---------NDAEGTVVGAENpk-----lAYQFYYELFRNTFLAIGQMIKEESWPdm-rYIPCE 319  migratory locust
AMA98202  259 yc--dCKNATVFYVKPrpn----qeYTDRYDLLKTKFglsgtpeiTVSFYFDIAVRTLMAAKTIMKGKPYWe--nYVTCN 330  German cockroach
KOB78263  261 sc--gCKDATIVYMRPtpd----akSRDRLGKIKTTYsmngepeiTSAFYFDLSLRTFLAIKSLLDSGKWPndmkYITCD 334  winter moth
AKO90023  272 lk-ceCRNMSVVFFKPilt----tsNQQHLSTLTTQGllpa-pwlASAFYYDFVRVGVEAIRSVIKNNKWPnepyHITCD 345  Microplitis mediator
EFX86214  256 pf-vrTENGSILFAVPtvnpdvangILFKTSGLNNGYs------vDTGFYFDLILRAITTVKNMLDGNTWPvdmsYSKCS 328  common water flea
AAM47017  271 qc--gCENASIVYLRPhts----adSRGRIAMLQRDYgltstpeiDAVAYFEYFMRGILGAAKMAAAGKYTdf-eYLRCE 343  American lobster

Feature 1                                                                               
NP_608863 333 DFQGGNTPqrnldlrDYFTKITEPTSYGTFDlv-tqSTQPFNGHSFMKFemdinVLQIRGGsSVNSKSIGKWIS 405 
AFP33229  320 EYEENKNVppt-rklNLLEALQQISMLNPGAyg--qLMLSSNGHSHMQFnm--tAFNVSLS-DNSATEVGTWAA 387  migratory locust
AMA98202  331 DYDEKSRPvp---dvNLMKAFTEVTEKPSYGp----FVLKSNGQSMMKFnmdmtLVTINNKiPVKSVEVATWEA 397  German cockroach
KOB78263  335 DYDGKNTPnr---tlDLKTAFQEVKETPTYAplfipQDDPINGRSYMEFstdlsAVTVKDGaSIGSKALGTWKA 405  winter moth
AKO90023  346 EYNGTNTPirnldllRHLQEATTNGFEPTFAg---fYWGKSNGEHHAEFdmriqMVVIENGnIVSADDLGTWKA 416  Microplitis mediator
EFX86214  329 MTNITAVTrn---nfDLRKAFADTNVGSTFAn----MILNGNGKSYPQVemtinQMNFKNSrLESKNALGIWKA 395  common water flea
AAM47017  344 EFSEDNPPvrn--dfDLRSALQSVSMTNTWAs----ISWGSNGMSYPDVpltmdKFKILAGrTAERKTLGEWSA 411  American lobster

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