2FQW,2HQB,4PEV,4IIL,3S99


Conserved Protein Domain Family
PBP1_BmpA_Med_PnrA-like
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cd06304: PBP1_BmpA_Med_PnrA-like 
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periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria
Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.
Links
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Statistics
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PSSM-Id: 380527
Aligned: 115 rows
Threshold Bit Score: 195.062
Created: 24-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2FQW; Treponema pallidum PnrA binds inosine, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ##        #                                                               
2FQW_A      6 VVGMVTDSgdiddksFNQQVWEGISRFAqe--nNAKCKYVTAst----dAEYVPSLSAFADeNMGLVVACgsflveAVIE 79  Treponema pallidum
KJS87427   21 KVSILIPGkhn-dngFMEAAYRGYSKIKdt--lPVEVSYVSDvsatsdkDVLTEAMRELAKkDANMIIGHggqcnePAKT 97  Desulfosporosinus ...
KZE82056   46 KVALLLPGpan-dggFMESAYRGLMKAKed--fRLKATYVDNvph--dtAKIADELRKLAKkKPDMIIAHagqsseAVKL 120 Paenibacillus elgii
ARP98394   33 KVAALFAGrid-dsgFMEAGYRGLMAARdk--lGVEVVWQDQikp--erDLLAAALRDLAKtGAAMVIAHggqnneAAKL 107 bacterium C16-RIPI...
OXS15016   30 KIAVLIPGkhd-dngFMQAAYRGYEKIKae--lDVNASYVSNisatsdpALLTEAMRKLAQeGPDLIIAHggqcngPAEI 106 Zobellella denitri...
OFI37399   38 HVAMLLAGsst-dkgFMQSGFTGLKRAEse--lGVSVSVKEGvap--ttEALAAGLRELAAsDPDMIIAHggqnsdAAVQ 112 Arthrobacter sp. SW1
SLN27874    2 KIGVIFVGevl-drgFNASALEGAQALRth--sGLDVEMIDGvp---ydTGAMTQALTAAAaRNDGVIFVggqgndVTPP 75  Rhodobacteraceae b...
OUO45565   39 EITVLLPGkah-dngFMEAGYRGYERIAkg--vTANVKCVSDvsatsdaAVLTAELQKLAKeQPKLIIGHggqmngPVSA 115 Megasphaera sp. An286
OZE99936   33 SVGVFFPGsis-dtgFMESGYLGYQRILdaygdKVDASYVEQva----aPDYQQALQRFAS-ENDLVISVggqtdaDVRK 106 Rhodococcus sp. 15...
OFX01381   16 TVGVLIPGsks-dkgWMESGYDGLKAVEkklgaKITVKYIENvk----fGDMEQVLVALAG-KNELVIGVggqtqaSVFK 89  Alphaproteobacteri...

Feature 1                  #                                                   #              
2FQW_A     80 TSARfPKQKFLVIDAvvqdr--dnvvSAVFgQNEGSFLVGVAAAlkakeagkSAVGFIVGMElgmMPLFEAGFEAGvkav 157 Treponema pallidum
KJS87427   98 VSKEfPNIKFVVIQGnvkg---dnlsSYVVkQEQSAWLAGALAGltt---ktNVVGHISGAWptpGLLGRAAFYDGlkyv 171 Desulfosporosinus ...
KZE82056  121 VSKEfPKIKFVNTQTsltg---dnlsSYQVkQEESAWLAGAAAGllt---ksNVVSHISGARvtpGFHGRAAFAGGlkyt 194 Paenibacillus elgii
ARP98394  108 VAAEfPQTRFVVTQGnvtt---tnlaSYEVlQEESAFLAGALAAwmt---ktGVVGHMSGIRvvpGLKGRAAYANGvaya 181 bacterium C16-RIPI...
OXS15016  107 VSKEfPDIRFVVIQGhvqg---pnlsSYVVrQEDSAWLAGALAGltt---rtDVVGHISGAWpqpGLIGRAAFYDGvkhv 180 Zobellella denitri...
OFI37399  113 VAKEfPDIAFVVTQAnvkg---anlsSYEVlQEHSAWLAGAAAGllt---ksNVVGHMSGIRpvpGLKGRAAYVDGvaht 186 Arthrobacter sp. SW1
SLN27874   76 VARAtPDCLFGVVQGavsg---pnlaSYDVlQEQSAFLAGCLAArvt---ksGVVGHLSGHRvapGLKGRAAFAAGvahi 149 Rhodobacteraceae b...
OUO45565  116 VSKEyPQIQFVVIQGsvkg---dnisSYVVdQEQSAFLAGALAGymt---ktGKVGHISGAWpkpGLQARAAFYNGvkya 189 Megasphaera sp. An286
OZE99936  107 VAPQfPDVKFVEIGGpadaepldnlaYYDPqQAEAEFLSGAVAAsvs---ttGAVAFVGGVElpaIVNAAASFEEGakft 183 Rhodococcus sp. 15...
OFX01381   90 VAPRfPKVKFAIIGGnadpkkpanvsGYDVrQAEIGFVAGAAAAmls---knGAVSYVGGLEipaIKNTGTEFGNGaryv 166 Alphaproteobacteri...

Feature 1                   #                                                   #             
2FQW_A    158 d-pdiqVVVEVANTFsDPQKGQALAAKLYDSGvNVIFQVaggtGNGVIKEARDRrlngqdVWVIGVDRDQYMDGvydgsk 236 Treponema pallidum
KJS87427  172 n-pdakFLTWFTGNLdDLEINRKAAEAEIKNNaDIIYTMlnagRTGVINEIKNNeg---kVRHIGNVSDWTQVDk----- 242 Desulfosporosinus ...
KZE82056  195 n-pnatFLTTFTGNQdDAALAKKVAQAQIAAGsDMIFTMlnvaRSGVTEAARENg-----VFQFGNVRDYYADAp----- 263 Paenibacillus elgii
ARP98394  182 n-pavrLLTNFSGHQdDNALSKRVASAMIAAKaDIIFTMlnagRAGAIDACREGg-----AKQIGNVRDWAAAIp----- 250 bacterium C16-RIPI...
OXS15016  181 n-pdakFLTWFTGDLdNTDINAQAAAAEIGQGaDVIYTMlnagRQGVIDEIKSHdg---kVRHIGNVSDWTQVDt----- 251 Zobellella denitri...
OFI37399  187 n-pkakVLSNFSGDQdDVELSRKIATAEIKAGaDYIFTMlnagRPGVAEAMKASg----kARQFGNVRDFTKDDp----- 256 Arthrobacter sp. SW1
SLN27874  150 d-paitLLTGFCGTQdDSAVTGAWVAAQARAGaDVVFTMlnaaRGGAIEACRAGg-----ILQIGNVLNWCDIAp----- 218 Rhodobacteraceae b...
OUO45565  190 n-phaqFYSTFTGDLdNMKVNAKAAEAQIGEGvDVIYTMlnsgRSAVNQVIAKTng---qVLEIGNVIDWTKESp----- 260 Megasphaera sp. An286
OZE99936  184 rpdirvLSPQYVGDFnDPAKAKQAASAEFAGGaDVLGQIvnlgKQGLQQAARESg-----ARLSGGPIPGDCSDp----- 253 Rhodococcus sp. 15...
OFX01381  167 n-pkikYIENYTGDFdDVAKAKEATLAAISQGaDVHYHIlnlgLRGMEQAAREKg-----THVIGSYTDRCGTDp----- 235 Alphaproteobacteri...

Feature 1             #                                      
2FQW_A    237 sVVLTSMVKRADVAAERISKMAYdgsfpggQSIMFGLe-DKAVGIPE 282 Treponema pallidum
KJS87427  243 -QFIGSAVADSSVAIFNSVNDFIngkwqanQVIEIGLkeSDVVKLTM 288 Desulfosporosinus sp. BIC-A1/1_c9
KZE82056  264 dVFIGSAISDAGFTVYGAIKDLAegkwkpnTVVKIGLenPDAVRLAL 310 Paenibacillus elgii
ARP98394  251 dVFVASAVADSGIALLRAVEDLVsgaaktnAIEKIGLnrPDAVRLTM 297 bacterium C16-RIPI 110
OXS15016  252 -SFVGSAVADASVAILNAARDFTtgqwqpdQITEIGLgqGDVVKLTL 297 Zobellella denitrificans
OFI37399  257 aIFAGSAVADSGAAAFQAVKDLVdgkfspgSTKHIGLenPEAVRLTL 303 Arthrobacter sp. SW1
SLN27874  219 eVFVGSALARIERAVLRAGLDMLarr-lpaEVQPMGLaqGDAVGLAL 264 Rhodobacteraceae bacterium DSSK2-3
OUO45565  261 -IFVGSAVADSSEALFNAAKDYKags-lthDITKIGLekPDIVRLAV 305 Megasphaera sp. An286
OZE99936  254 -AYVGYVRTDIGTEIEYAVSSALdgt-waaEQVPFGLtsDKGGTDYL 298 Rhodococcus sp. 15-1189-1-1a
OFX01381  236 -LYVAYSVTGVGFQVEYAIEQAAagt-wkpEFKPFGLamGPKSSDMV 280 Alphaproteobacteria bacterium RIFCSPHIGHO2_12_FULL_...

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