2C9A


Conserved Protein Domain Family
MAM

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cd06263: MAM 
Click on image for an interactive view with Cn3D
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.
Statistics
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PSSM-Id: 99706
View PSSM: cd06263
Aligned: 86 rows
Threshold Bit Score: 78.1885
Threshold Setting Gi: 146328566
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative adhesion site
Evidence:
  • Comment:mutation of these conserved charges resulted in a reduction in adhesive interactions in RPTPmu

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ##                                                                           
2C9A_A       7 CLFDEpy------stCGYSQseg-----------ddfNWEQvntltkpt-----------sdpwxpsGSFXLVNAsgrp- 57   human
Q4SXP5     211 CDFDDg--------sCGWFEltpg----------dgfDWVRgtsaevpphfygy-pppldhttssteGHFMFILKnsss- 270  Tetraodon nigrov...
ABY83136   277 CSFELg--------sCGWSAadt------------qsSWRLvsgqqliedth-----llgttlkntqGHFLFLKVrghg- 330  zebrafish
Q6UXC1     475 CDFEEqcaggedeqaCGTTDfespeaggwedasvgrlQWRRvsaqesq------------gssaaaaGHFLSLQRawgq- 541  human
Q4SK08     183 CSFEDg--------dCSWKPiag-----------rtlSWKRlqssakpp-----------rqscpssGATFSVEGghak- 231  Tetraodon nigrov...
NP_652600  288 CNFETp---------CSWTWgnys----------dgfQVITgtelskrnltgll-pgpaadsiddanGHFLYARVnps-- 345  fruit fly
Q17E33      18 CNFETe---------CAWKAdetn---------pnsfQVVTganltasnrtgmm-pgpssdilgdanGHFLHLRLtsn-- 76   yellow fever mos...
Q9UM73     480 CNFEDg--------fCGWTQgtls---------phtpQWQVrtlkda--------------rfqdhqDHALLLSTtdvp- 527  human
ABY83136    53 CDFESp---------CSWTLssh-----------stgGEWFitsaqqhrsnrrdtqpirdystgkseGHFLLLKPssshl 112  zebrafish
Q9UM73     266 CSFDFp---------CELEYspplhd-----lrnqswSWRRipseeasqmdlld-gpgaerskemprGSFLLLNTsa--- 327  human
Feature 1                                                                                      
2C9A_A      58 --egqRAHLLLPQLKen--dTHC---IDFHYFVSSksnsppGLLNVYVKVnngp--lgnPIWNISgdp--trtWNRAELA 126  human
Q4SXP5     271 --lypQAVLQGPWFRqs--aSGCt--MTFWHYNSGis---vGAANMNLRIkgdp--nntVIWRTLydq--gpqWKQTTVQ 337  Tetraodon nigrov...
ABY83136   331 --derEALVQSPALPstisnQDCq--LQFSLYRYGdf---nGTVLLSVVEsgas--apaLIWERSghw--kdaWQEITLP 399  zebrafish
Q6UXC1     542 --lgaEARVLTPLLGps--gPSCe--LHLAYYLQSqp---rGFLALVVVDngs----reLAWQALsss--agiWKVDKVL 606  human
Q4SK08     232 -gqrgSALLRSPLFPpplrnSPCt--VRFWLCSRGlh---kGSLSLWLLEnstgpeeqrPLWSSAseakseksWKLITLP 305  Tetraodon nigrov...
NP_652600  346 ---srPLNLTSPEFStt--mEKCf--LEVYMHQSDm----sHGLSRVVVEllht--aesSWVPAEilgdnvrqWTRKVYR 412  fruit fly
Q17E33      77 ---stQHILTSPMFGat--rEHCy--LEMMTHQSSmg---hGTLRIVIETsgn---qdpSWVPAEvfgndlskWQRTTFR 143  yellow fever mos...
Q9UM73     528 --aseSATVTSATFPapiksSPCe--LRMSWLIRGvl---rGNVSLVLVEnktgkeqgrMVWHVAayeg-lslWQWMVLP 599  human
ABY83136   113 saarcSFHMTSPVVLss--gPFCh--LQLARFQPEph---aGNISAFVKHtdsidikpiDLTIKEqesd-ssqWEVLEAV 184  zebrafish
Q9UM73     328 ---dsKHTILSPWMRss--sEHCtlaVSVHRHLQPsg---rYIAQLLPHNeaa----reILLMPTpgk---hgWTVLQGR 392  human
Feature 1                                              
2C9A_A     127 ISTfwpnFYQVIFEVITsg----hqGYLAIDEVKVLghpC 162  human
Q4SXP5     338 LGRlt-qPFQISLSKISlgv---fdGVSALDDVTFSn--C 371  Tetraodon nigroviridis
ABY83136   400 ITEil-nGFHLKVQAFWtsg---skADIALDDISLSa-aC 434  zebrafish
Q6UXC1     607 LGArr-rPFRLEFVGLVdldg-pdqQGAGVDNVTLRd--C 642  human
Q4SK08     306 LYGla-dWFWLQFSTENgpg---pgSSVSLDNISFSm-dC 340  Tetraodon nigroviridis
NP_652600  413 LGRvs-rDFRIVFEVVPdlrv-gqkGHVALDNLRMVn--C 448  fruit fly
Q17E33     144 IDRis-kDFQILFEVVPnrlggrarGHVSIDNLKLVn--C 180  yellow fever mosquito
Q9UM73     600 LLDvs-dRFWLQMVAWWgqg---srAIVAFDNISISl-dC 634  human
ABY83136   185 IGQln-ePFQVTVQYSAcss--hevGFLAFDSLELKn--C 219  zebrafish
Q9UM73     393 IGRpd-nPFRVALEYISsg----nrSLSAVDFFALKn--C 425  human

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