2R6G,3DHW,3DHW,2R6G,2ONK,2ONK,3D31,3D31


Conserved Protein Domain Family
TM_PBP2

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cd06261: TM_PBP2 
Click on image for an interactive view with Cn3D
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.
Statistics
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PSSM-Id: 119394
View PSSM: cd06261
Aligned: 252 rows
Threshold Bit Score: 33.0209
Threshold Setting Gi: 81780698
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative PBP binding loops
Evidence:
  • Structure:2R6G_E/F/G; Escherichia coli maltose transporter, interface of the TMs (MalG and MalF) with maltose binding protein, contacts at 3.5 A.
    View structure with Cn3D
  • Structure:2ONK_C/D/E; Archaeoglobus fulgidus ModBC, interface of ModB TMs with (ModA) PBP subunits, contacts at 3.5 A.
    View structure with Cn3D
  • Comment: the highlights delimit the borders of two regions involved in PBP binding which includes three loops.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #                     
2R6G_F    281 FVWTVVFSLITVFLTVAVGMVLACLVQWealr--gkavYRVLLILPYAVPSFISILIFKglfnqsfgeinmmlsalfgvk 358 Escherichia coli K12
P75185     70 LLVSFVVSIGSLIIASYIGVRTSIFLVYrckpr-irkkLLLVIDILSGIPSVIFGLFATqilssifrd------------ 136 Mycoplasma pneumon...
P47651     70 LLVSFIVSIGALIIASYIGVRTSFFLVYrckpk-irkkLSLIIDILSGIPSVIFGLFASqilsiffrd------------ 136 Mycoplasma genital...
P07654     83 LAGSGLLILWATVFGTPLGIMAGIYLAEygrkswlaevIRFINDILLSAPSIVVGLFVYtivvaq--------------- 147 Escherichia coli
Q9PBK1     71 FFGSAIMCLLAIVIGTPLGIAAGTWLAEygntsktsavVRFVNDILLSAPSIVLGLFVYtlyvmht-------------- 136 Xylella fastidiosa...
Q50097     85 LYGSLVQAVVAAIMAVPLGSMTAVYLVEygsgp-fvrvTTFMVDVLAGVPSIVAALFIFclwiatl-------------- 149 Mycobacterium lepr...
O86345     89 LYGTLVQAGVAAVLAVPLGLMTAVYLVEygtgr-msrvTTFTVDVLAGVPSIVAALFVFslwiatl-------------- 153 Mycobacterium tube...
Q58419     68 IVGTLMLTFLATLIGLPLAFLAGAYAYEfpnsf-igraTKMLLQIMLEFPTILVGTFVMgmlvvp--------------- 131 Methanocaldococcus...
P0A626     83 IIGTAVLAIGVILVGGTVSVLTGIYLSEfatgk-trsiLRGAYEVLSGIPSIVLGYVGYlalvvyf-------------- 147 Mycobacterium tube...
P75185    413 LVNTLVIILVAIGITFPIALLIAIWLNEytksriakntFSFVIDSLSSMPSIIYGLFGLsfflrtlqls----------- 481 Mycoplasma pneumon...
Feature 1                  #                                                                  
2R6G_F    359 pawfsdpttaRTMLIIVNTWLgYPYMMILCMGLLKAIpDDLYEASAMDGAGPfqNFFKItLPLLIKPLTPLMIASFAFNF 438 Escherichia coli K12
P75185    137 -vlhlpplslLNVIVMLSFMI-IPIVISLTTNALLHVeSSLMTVAISLGENKtsVIYKViKKEIKAQLVVILVLAFGRAI 214 Mycoplasma pneumon...
P47651    137 -ilklpplslLNVIAMLSFMI-IPIVISLTTNTLTYVnNDLISVVVSLGENKtsAIYKIiKKEIKPQLTVILTLAFARAI 214 Mycoplasma genital...
P07654    148 ----mehfsgWAGVIALALLQ-VPIVIRTTENMLKLVpYSLREAAYALGTPKwkMISAItLKASVSGIMTGILLAIARIA 222 Escherichia coli
Q9PBK1    137 ----gghfsaFSGALALVFIV-LPIVVRTTDEMLRLVpGQMREAALSLGIPQwkMIIQVlYRSASAGILTGILLALARIS 211 Xylella fastidiosa...
Q50097    150 ----gfqqsaFAVSLALVLLM-LPVVVRSTEEILRLVpDELREACYALGIPKwkTIVRIvFPIATPGIISGVLLSIARVI 224 Mycobacterium lepr...
O86345    154 ----gfqqsaFAVALALVLLM-LPVVVRAGEEMLRLVpDELREASYALGVPKwkTIVRIvAPIAMPGIVSGILLSIARVV 228 Mycobacterium tube...
Q58419    132 ----mgtfsaLAGALALALIL-TPYVAVYTEEAMAEVpKIYKEGGYALGCTRaqVIFKViTKMAKKGILTGILIGMAKVA 206 Methanocaldococcus...
P0A626    148 ----dwgfslAAGVLVLSVMS-IPYIAKATESALAQVpTSYREAAEALGLPAgwALRKIvLKTAMPGIVTGMLVALALAI 222 Mycobacterium tube...
P75185    482 -aggangtslMAGILTISVVV-LPFLIRTCQEALNNVsWDLRVSAYALGVSKreVIWKIvLPGALKGLIIALILTINRII 559 Mycoplasma pneumon...
Feature 1           #                         #  #                    #                
2R6G_F    439 NNFVLIQLltnggpdrlgt--ttpagytdllvNYTYRIafeg----------gggqDFGLAAAIATLIFLLVG 499 Escherichia coli K12
P75185    215 SETMAVNFilqsvnyqevi--andrfftsdlkTLGSVIstfifsengdeqvsgvlyTFGIIIFVLISFLNFFA 285 Mycoplasma pneumoniae M129
P47651    215 SETMAVNFvlqsvnyqevi--nnnrfftsdlkTLGSVIstfifsengdeqingvlyIFGIIILILVSLLNFFA 285 Mycoplasma genitalium G37
P07654    223 GETAPLLFtalsnqfwstd---mmqpianlpvTIFKFAmspfae-------wqqlaWAGVLIITLCVLLLNIL 285 Escherichia coli
Q9PBK1    212 GETAPLLFtafgnqywssn---ifqpiaslplVMNQFAsspyks-------wqllaWSGALVLTVFVLLVSLG 274 Xylella fastidiosa 9a5c
Q50097    225 GETAPVLVlvgysrsinfd---ifdgnmaslpLLIYTEltnpey-------agflrVWGAALTLIILVAGINL 287 Mycobacterium leprae TN
O86345    229 GETAPVLVlvgyshsinld---vfhgnmaslpLLIYTEltnpeh-------agflrVWGAALTLIIVVATINL 291 Mycobacterium tuberculosi...
Q58419    207 GETAPLLFtagglyevypt---nplepvgaipLLIYTLvqspsi-------edhqmAWGAALVMLIIFLAIFV 269 Methanocaldococcus jannas...
P0A626    223 GETAPLLYtagwsnspptgqltdspvgyltypIWTFYNqpsksa------qdlsydAALLLIVFLLLLIFIGR 289 Mycobacterium tuberculosi...
P75185    560 AETAPFFItaglassnlf----dlslpgqtltTRIYGQlfstnst-----avdvmlETALVSIVFLMFLIFLS 623 Mycoplasma pneumoniae M129

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