Conserved Protein Domain Family
M14_AGBL5_like

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cd06236: M14_AGBL5_like 
Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
Peptidase M14-like domain of ATP/GTP binding protein_like (AGBL)-5, and related proteins. The Peptidase M14 family of metallocarboxypeptidases are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. This eukaryotic subgroup includes the human AGBL5 and the mouse cytosolic carboxypeptidase (CCP)-5. ATP/GTP binding protein (AGTPBP-1/Nna1)-like proteins are active metallopeptidases that are thought to act on cytosolic proteins such as alpha-tubulin, to remove a C-terminal tyrosine. Mutations in AGTPBP-1/Nna1 cause Purkinje cell degeneration (pcd). AGTPBP-1/Nna1 however does not belong to this subgroup. AGTPBP-1/Nna1-like proteins from the different phyla are highly diverse, but they all contain a unique N-terminal conserved domain right before the CP domain. It has been suggested that this N-terminal domain might act as a folding domain.
Statistics
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PSSM-Id: 349455
Aligned: 25 rows
Threshold Bit Score: 318.053
Created: 5-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding siteactive site
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:[H] [ED] [H]Click to see conserved feature residue pattern help
Evidence:
  • Comment:Metallocarboxypeptidases share the zinc binding motif HXXE...H, where the zinc ion is penta-coordinated to ND1 atoms of the histidines, OE1 and OE2 atoms of the glutamic acid, and to a water molecule in a slightly distorted tetrahedral manner.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
Q8NDL9     183 SSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGlred----reprLEQLFPDtstp---------rpfRFAGKRIFFLSS 249  human
ETW08637   195 RTTSQPIYYHRETLVHSLDGRKVDLITISSLDNimde----reemLPDLFPDhpiv--------prphQFQNKRVVFVTA 262  Aphanomyces inva...
CBY23277   187 KPVFSDIYFHREILCRTIDGRPVELLTISSAAGitddvepnfahnLPPPFPEt--------------rKFTDKRAFIISA 252  Oikopleura dioica
EDP00671   255 DEGPSRLYYRRQLLTRSLEGRRIEVITITDCAGaagagggeleppLPGVFEHdpgpp-------aatfSPEHKKVFFVSS 327  Chlamydomonas re...
AAX79741   296 TPYTTDVYFSHEILCKSLDGLNVDLLTITDYLGvs--------ekRVPLFSNgeapyssvrgetsrphLFSGKLAVVLTA 367  Trypanosoma brucei
ACO65156   220 KTLRERVYVRRQTLARSLEGRDVDVLTVTAPAGvses----eydeAPVLSSRvap----------pgrAPEDRPVFIVSA 285  Micromonas sp. R...
EKX31473   176 KTSESAIYLERETLTYSLEGRRMEVLTITDYFGasse----reeeIENLFPEgkq----------rplVFPEKKYFVLSA 241  Guillardia theta...
CEO96022    89 LTPDPTVYFHRKCLGISAGGRRIDMLTVTSAEGenag----cssgHIEPCSDscg-----------srLAQHRPVVFLSA 153  Plasmodiophora b...
EDQ88114   222 PAPKPGIYYHHDVITHTLEGRHLDLMTITSYDGqeat----rearLPSLFPDtahp---------rahTFGAKPVFFISA 288  Monosiga brevico...
ODN06407   192 SSTESDIYYHRECVCLSYEGRRVELITVTSMNGvsna----reerLTNLFPItsep---------rpfKFPGKKVVFMSA 258  Orchesella cincta
Feature 1        #  #                                                                          
Q8NDL9     250 RVHPGETPSSFVFNGFLDFILRpdDPRAQTLRRlFVFKLIPMLNPDGVVRGHYRTDSrGVNLNRQYLkpd--avLHPAIY 327  human
ETW08637   263 RVHPAETPSSFVLDGVLNFLLKd-DPRAHKLLKeCVFKIIPMLNPDGVARGHYRHDSlGANLNRHYIrpt--maAHPTIY 339  Aphanomyces inva...
CBY23277   253 RVHPGETPASHVLRGMVNFILRtdDKRSATLRAhYVFKIIPVLNPDGVFRGHYRTDArGQNLNRFYLnpd--isLQPQCF 330  Oikopleura dioica
EDP00671   328 RVHPGETPATHMFNGLLAFLLRrtDPRAAALRRrFVFKLVPIVNADGVAVGNYRTDTlGQNLNRYYLgtp-deqTQPAVF 406  Chlamydomonas re...
AAX79741   368 RVHPGECPSSHMMHGCIEFLLNkgDPRAEALRShFVFYIVPMINPDGVARGHTRVDTeGVNLNRAYRtps--krRHPAPY 445  Trypanosoma brucei
ACO65156   286 GVHPGEKPGNHMMCGILEFLLRpdDPRASALRErFVFKLVPMLNPDGAFRGHFRQDTlGQNLNRFYDdpd--rtKQPVIH 363  Micromonas sp. R...
EKX31473   242 RVHPGESPAQWMWDGAIDFLVNkeDPRAKALRRaFVFKVVPIINPDGVARGHYRADTqGLNLNRFYDapd--rtRHPTVW 319  Guillardia theta...
CEO96022   154 RVHPGESPASFIMNGFIDFILQtgDPIAVALRNlFLFKIVPMLNPDGVAAGNYRTDVmGNDLNRHYNsassgldIACVVR 233  Plasmodiophora b...
EDQ88114   289 RVHPGETPASHMFNGALRFLLDpdDPRAALLRQrYVFKLVPMLNPDGVARGHYRCDTrGANLNRFYNnpd--reHQPTIW 366  Monosiga brevico...
ODN06407   259 RVHPGETPSSFVLNGFLEFLLKpnHPQAILLRRlFVFKFIPILNPDGVVRGHYRTDPrGVNLNRVYLnps--pvLHPPIY 336  Orchesella cincta
Feature 1                                                                                      
Q8NDL9     328 GAKAVLlyhhvhsrlnsqsssehqpssclppdapvsdlekannlqneaqcghsa----------------------drhn 385  human
ETW08637   340 AAKRAIlascgt-------------------------------------------------------------------- 351  Aphanomyces inva...
CBY23277   331 AYRQLVfhlhknyrldgvevpndid------------------------------------------------------- 355  Oikopleura dioica
EDP00671   407 AIKALLmhyaq--------------------------------------------------------------------- 417  Chlamydomonas re...
AAX79741   446 HIRGLLdslset-------------------------------------------------------------------- 457  Trypanosoma brucei
ACO65156   364 AVVRLAmhyahq-------------------------------------------------------------------- 375  Micromonas sp. R...
EKX31473   320 AIKELVvwlkg--------------------------------------------------------------------- 330  Guillardia theta...
CEO96022   234 EIGVLAetr----------------------------------------------------------------------- 242  Plasmodiophora b...
EDQ88114   367 AIKTLIayhhy--------------------------------------------------------------------- 377  Monosiga brevico...
ODN06407   337 AARKLLlyyhngvdwpddyeypvdaestdmndvsmeemkcsenvdccssaslggessmssfpdhadlsatptaailqdni 416  Orchesella cincta
Feature 1                                                      #                               
Q8NDL9     386 aeawkqtepaeqklnsvwimpqqsagleesapdtippkesgvaYYVDLHGHASKRGCFMYGNSFsdest--qvenMLYPK 463  human
ETW08637   352 --------------------------------------hsklaLHIDLHAHAAKRGCFIYGNRYkslnd--qaasQVYPK 391  Aphanomyces inva...
CBY23277   356 -------------------------stvqdyesltedkesgvgFLIDLHAHAAKRGAFLFGNRLklady--haetLCYAR 408  Oikopleura dioica
EDP00671   418 --------------------------------------qgllqYYIDLHAHANKKGVFIFGNTLedgea--hlqsLIYSR 457  Chlamydomonas re...
AAX79741   458 --------------------------------------kgklaLFIDMHAHSNKRGMFFYGNSMdape---llqcLLYTK 496  Trypanosoma brucei
ACO65156   376 --------------------------------------rrglgFYLDLHGHMNKRGVFAFGNALdgdd---aaagFAYAR 414  Micromonas sp. R...
EKX31473   331 --------------------------------------rtnlkFFVDLHAHATKRGCFCYANALptyqe--midnMMYAR 370  Guillardia theta...
CEO96022   243 ----------------------------------------rlqYYIDIHAHANKKGVFVYGNAVgdkq----petLLFAR 278  Plasmodiophora b...
EDQ88114   378 --------------------------------------kgnlaFYIDLHAHATKRGSFIYGNNLpsqr---qvdnVLFAQ 416  Monosiga brevico...
ODN06407   417 eegagdctkkemkkpytfvlskanslcagcgpfidpnaedavmSAEDLQPSTSSCSLNDSGQSHhqcafeacdedSVFYE 496  Orchesella cincta
Feature 1                                                                                      
Q8NDL9     464 LISLNSAHFDFQGCNFsekn---------myarDRRDGQSKEGSGRVAIYKASGi----iHSYTLECNYntgrsvnsipa 530  human
ETW08637   392 LIGLNSVYFEYDQCNFseqnm--------hlveKRDGGLSKEGSARVALHRETSaisppvYFYTLECNYnmgrractiph 463  Aphanomyces inva...
CBY23277   409 LTAANSAHMDFDACCFsqrn---------mnmkDKRDQLSKEGSCRVAFYYLTGs----pHIYTLECNYntgryqnaiss 475  Oikopleura dioica
EDP00671   458 LVALNNPVFDFVGCNFtekn----------msrADKDGASKEGAGRVALYRETGl----tHLYTIEANYntsarvntvap 523  Chlamydomonas re...
AAX79741   497 LVSLNTPYFEFQSCNFsean----------mfaTGKTGEGRDNSSRVTLYQRTGm----iHSYTIEASHvvgnalngvaa 562  Trypanosoma brucei
ACO65156   415 LCSLNTPHFDVHACNFtekn----------mrtQDKNGQTKEGSGRVALHAKTGl----pHLYTVEASYvssrllsrvpp 480  Micromonas sp. R...
EKX31473   371 MIAINSAHFDFGSCVFseka----------mesKDRNGQSKEGSSRVGIYRATGl----vHSMTPPAATqdpraspgetw 436  Guillardia theta...
CEO96022   279 LMEMTTPTFSFEACRFsskl----------mcaRDRRGQSRSGSGRVSVFRQTGi----tHSYTLETNYctdrgrt---- 340  Plasmodiophora b...
EDQ88114   417 LVAMNTPHFDFEGSVFsernmlakarlravrcvIISTPARIPLPSLPFLTSHIGifffglMCYTLESNYgtgrvsnllgp 496  Monosiga brevico...
ODN06407   497 NLSLKNSSSSLAATSKeslpetp----krsssrSSSGRRRRKGSVRERKKKVTKsa---sKAKTSKNNKksdeaettpyl 569  Orchesella cincta
Feature 1                                                                                      
Q8NDL9     531 achdng---------------------------------------------raspppppafpsrytveLFEQVGRAMAIA 565  human
ETW08637   464 sgsglmst-----------------------------------------aplspevarkayvpkyttaSWEDVGKGMMVA 502  Aphanomyces inva...
CBY23277   476 rdgal------------------------------------------------tppiqpaplvkyapdHYAEVGRGLLCA 507  Oikopleura dioica
EDP00671   524 asgdhag--------------------------------------------rasppcnrrfppkftasVLQGVGRAIAVA 559  Chlamydomonas re...
AAX79741   563 lmnspv---------------------------------------------eeaevqqngtcpryttaMFGDVGKALLVA 597  Trypanosoma brucei
ACO65156   481 asgddgr--------------------------------------------asppsrtpvrsvkytpeVLNDVGRALMIA 516  Micromonas sp. R...
EKX31473   437 ----------------------------------------------------------rgplpkfntsIFRDVGKALMVA 458  Guillardia theta...
CEO96022   341 --------------------------------------------------------------tvftvdAFKDIGSALAKT 358  Plasmodiophora b...
EDQ88114   497 mtgqg-----------------------------------------------pgqahispapvpygipEWEDVGVAMLAA 529  Monosiga brevico...
ODN06407   570 qmllpskpieattrykdklrskanisatlanpvnykisspisgpdsglflyldmhghttkrgifmygnHFPDATKQAECM 649  Orchesella cincta
Feature 1               
Q8NDL9     566 ALDMAECNP 574  human
ETW08637   503 VLDWLGTNE 511  Aphanomyces invadans
CBY23277   508 VLDVFTMNP 516  Oikopleura dioica
EDP00671   560 ALDMEGANP 568  Chlamydomonas reinhardtii
AAX79741   598 LLDLKGWNP 606  Trypanosoma brucei
ACO65156   517 ALDLQGEGA 525  Micromonas sp. RCC299
EKX31473   459 ALDMEELNP 467  Guillardia theta CCMP2712
CEO96022   359 LLAMASDHH 367  Plasmodiophora brassicae
EDQ88114   530 VLDLKDLNP 538  Monosiga brevicollis MX1
ODN06407   650 LLPRLMAIN 658  Orchesella cincta

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