Conserved Protein Domain Family
sulfite_reductase_like

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cd06221: sulfite_reductase_like 
Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is linked to ferredoxin and reduces NH2OH and SeO3 at a lesser rate than it's normal substate SO3(2-). Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+.
Statistics
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PSSM-Id: 99817
View PSSM: cd06221
Aligned: 36 rows
Threshold Bit Score: 235.194
Threshold Setting Gi: 119503735
Created: 22-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   # ####             ###   ###        
BAB81145     15 VKKHTDIe---yTFRMEFKg---------dVKPGQFFEVSLPKFGEAPISVSGIge--dYVELTIRRVGVVTNEIFEKyE 80  Clostridium perf...
YP_149648    24 ITRHTPL-----EWNFRVAvd-------fpAHWGQFVEVSLPRVGEAPISVSDYgd--gWIDLLIRNLGKVTSALFTLkE 89  Salmonella enter...
YP_430026    17 VLAIQPQtgvdyTFRLATDi---------ePAWGQFVEISLPGVGEAPISVSDAgp--gYIELTIRRVGKVTTALHQLkP 85  Moorella thermoa...
EDK88687     18 IIKHTDIe---wTFRVNADts--------kTKPGQFYEISLPKFGESPISVSGIge--dYIDFTIRAVGRVTNEIFEYkI 84  Fusobacterium nu...
NP_562453    12 IIDIVKEtd--kEWTFRIAsd-------vvPEHGQFLELSLPKVGEAPISVSGFgp--gYLDFTIRAVGKVTDEIFKLkP 80  Clostridium perf...
ZP_01164925  13 VESYVSEsp--sIFTLKLRltnaadraayqFMPGQFNMLYMFGVGEVPISIVSDpddptLIEHTIRIVGRVTQAMAKLkE 90  Neptuniibacter c...
YP_315019    17 VVARVEEsp--gVFTLRVRlddpgaqaayrFAPGQFNMLYLYGAGEVPISIMSDpeerdAIGHTIRAVGRVTQGLAALgP 94  Thiobacillus den...
YP_096476    16 IIQRTQEss--sIFTLHFRftdeehhkqfqFYPGQFNMLYLYGVGEVAISIVSDprkktFLSHTIRAVGRVTKAMQKLqV 93  Legionella pneum...
ZP_00417715  11 LLEFHDEgegirHFSFALQslrs---gdqaVMPGQFFMLTVPGAGEAPFSYVRPpdwqgRFSALIRREGTVSAALFAQeP 87  Azotobacter vine...
NP_971592   338 IVKIEKEsediiIITLNGKc---------kFEAGQFVFLWIPGAGEKPFSLAEAd----PISLIIKKRGPFTEALFELkA 404 Treponema dentic...
Feature 1                                     #                                                 
BAB81145     81 GDKLFLRGPYGNGFDVnnykGKEVIVVAGGTGLSPVKGIVDYFSQnpkdaESFTLISGFKGPk----------dILFKDD 150 Clostridium perf...
YP_149648    90 GDNVWLRGCYGNGYPVdtlrHKPLLVVAGGTGVAPVKGLMRYFVEnpqeiGQLDMILGYKNRd----------cVLYKEE 159 Salmonella enter...
YP_430026    86 GDTVYLRGPYGSGFPRdefaGHQLVVAAGGTGVAPVKGLINYYAGhpgelAGLNLLLGFKTPa----------dILFRTD 155 Moorella thermoa...
EDK88687     85 GDKLFIRGPYGNGFDLneyvGKDLVIVVGGSALAPVRGIIQFVYNnpekvKSFKLIAGFKSPk----------dVLFAKD 154 Fusobacterium nu...
NP_562453    81 GDKISLRGAYGKGWPVeqfkDKNVIIVAGGTGVAPVRSLINKFYDepnyvETLSLVFGFKNSe----------gILFKND 150 Clostridium perf...
ZP_01164925  91 GDQVGLRGPFGRGWPMalgrEKDLLIITGGLGCAPVVAAINYALQrrehyGKVSIVQGVKHSd----------dLIWEEQ 160 Neptuniibacter c...
YP_315019    95 GDAIGLRGPFGRGWPLrevsGSDVVLVTGGLGCAPAVSVIHYVLRrrerfGKLVIIQGVRHAd----------dLIWREH 164 Thiobacillus den...
YP_096476    94 GDRLGIRGPFGVGWPLqktiGKDIIVLTGGLGCAPSVSIINYILGrrrhyGKLSILQGVKHSe----------dFIFRKQ 163 Legionella pneum...
ZP_00417715  88 GSRLGYRGAFGTGWPEls-gARRVLVVAGGSGLAALAGLIEALLRag-hqAALTLVYGARSPg----------hQVLARE 155 Azotobacter vine...
NP_971592   405 GDTIYMRGLYGKGIKPp--kTENALLIAGGTGIAVLPALAKRLKKq---gALVSTYVGTSEEikkkepngiekiLIECGA 479 Treponema dentic...
Feature 1                                                                                       
BAB81145    151 MKEWek---nmNMIITVDSAeegyeGNTGLVTKYIPEleikd-mdnvqVIVVGPPMMMKFTVLEFLKRGikeENIWISQE 226 Clostridium perf...
YP_149648   160 MATWrg---khNLVLTLDEGeaddrYQIGRVTDRLADmtlsd-idtmqAIVVGPPIMITFTVKMLLQKGlkpEQIWVDYE 235 Salmonella enter...
YP_430026   156 IERWqg---lfPTILTVDQGqagwsGKVGLVTEFVKEiplk---ndarIIVVGPPLMIKFTVAEFIKCQikpEQIWVSLE 229 Moorella thermoa...
EDK88687    155 LEEWsk---klDVILTVDGAeegykGNIGLVTKYIPElkfnd-lsnvsAVVVGPPMMMKFSVAEFLKLNvaeKNIWVSYE 230 Fusobacterium nu...
NP_562453   151 LDRWne---kfNTIYTLDNDtk-egWETGLVTVHLNKlplesfgdnyeVIIVGPPVMMHFTALEFLKLGvpeEKIWVSFE 226 Clostridium perf...
ZP_01164925 161 YKEWqql-hnvEVNLAADESgpawpFHQGRITELLDKvsvdi--ansvALICGPEGMMDAAARRLLSLGmpgYSIYVSLE 237 Neptuniibacter c...
YP_315019   165 YDRWakl-patQVLVAADVAtplwpWHVGRVTDLFGLarfdp--egavAMMCGPEGMMRTAGNGLLALGlpeARLYLSME 241 Thiobacillus den...
YP_096476   164 YAKWqks-dhtEVYIAADQAgpkwpWGVGYVTDLIDHiiiqp--dnsvVMMCGPEMMMNTAVKVFTQKGileNDIYLSME 240 Legionella pneum...
ZP_00417715 156 RARWre---alELIETLERRe---dGRVGCNPLEPLRsrlas-qvpdaVLCCGPEPLMRSVAELCLAHGvppTGIWLSIG 228 Azotobacter vine...
NP_971592   480 YKKVadkgvigRVLNQFQKDni--eGNTGLPIQGKAEkmgkq--dfftAYLVGPMIFMRRASEILLKLGvrkSQIFMSLE 555 Treponema dentic...
Feature 1       ##                           
BAB81145    227 RKMCCGLGKCGHCKIDDTYICLDGPVFNY 255 Clostridium perfringens str. 13
YP_149648   236 RRMACSVGKCGHCRMGEVYVCTDGPIFNY 264 Salmonella enterica subsp. enterica serovar Paratypi A str. ATCC 9150
YP_430026   230 RRMHCGLGKCGHCKINDVYVCLEGPVFNY 258 Moorella thermoacetica ATCC 39073
EDK88687    231 RNMHCGIGKCGHCKMDATYICLDGPVFDY 259 Fusobacterium nucleatum subsp. polymorphum ATCC 10953
NP_562453   227 RKMSCAVGKCGHCRINETYVCLEGPVFNY 255 Clostridium perfringens str. 13
ZP_01164925 238 RNMQCAVGHCGHCQMGADFICKDGPVFVY 266 Neptuniibacter caesariensis
YP_315019   242 RNMQCAVGRCGHCQIGAAFVCHDGPVFSW 270 Thiobacillus denitrificans ATCC 25259
YP_096476   241 RNMECGIGHCGHCQYGGLFVCKDGPVFAY 269 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
ZP_00417715 229 RRLDCGMGHCGRCHVGRGSVCQEGPVYRY 257 Azotobacter vinelandii AvOP
NP_971592   556 MNTMCGVGICGECSCGNILTCKKGTFVSL 584 Treponema denticola ATCC 35405

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