Conserved Protein Domain Family
DHOD_e_trans_like2

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cd06220: DHOD_e_trans_like2 
FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.
Statistics
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PSSM-Id: 99816
View PSSM: cd06220
Aligned: 21 rows
Threshold Bit Score: 306.097
Threshold Setting Gi: 21759368
Created: 3-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 # ####             ###   ###           
P58886         6 VTITQITEEsplVRTFFFDHRfe---dMDPGQFVMVWVrGVDEVPMGLSR------NNSITVQKVGEATSKLFELk-eGD 75  Methanosarcina ...
O29722         7 TQIERLTDE---VATLYFSISl----rSYPGQFVMVYVpGCEEIPLSLSS------SNSVTVKAVGETTASLINAk-eGQ 72  Archaeoglobus f...
P58887         9 AEVVENREEc--ERTIVLRLRperpirWEPGQFLMLGIsGVDEKPMAFSGgd--drEFELTIEIVGPFTERCADLe-pGD 83  Methanopyrus ka...
YP_920561      6 ARVAEVLDLapsVKMYILELSrp--fgSQPGQYVMVWLpGVGEFPVSVAGek--ggALRLVVARKGRATGYMHERvaeGG 81  Thermofilum pen...
YP_001582723  11 VTVEKVIDEtptVRTLVFSDEvm--snVLPGQFAMVWIpGINELPMSVMIsde-sgKAAFTVRKHGAASTGLFNVk-vGE 86  Nitrosopumilus ...
ABK77188       1 MEIERVIDEtptVRTLLFQDDim--egALPGQFAMVWVpGAGELPMSVMAaee-pgMAAFTVRRRGAASTGLYDTa-kGG 76  Cenarchaeum sym...
YP_448434     14 VEIKETIIEtptVKTFIFPWNit--ddIHPGQFVMVWD-LHNEKPMTISIidrennLMGITIRKAGPFTENMYDNmdvGD 90  Methanosphaera ...
CAJ74952       8 VKIYDIIDEtpnVKTFFFEYAg----qYEPGQFIMVWVpLNDEKPFTISYid--gnVAGITVLKRGEFTKTLHTKk-kGD 80  Candidatus Kuen...
Q9HL36         4 ITVDQVRDEaknVRTLFFRWDh----dVKPGQFVMVWLpGLGEIPMSLSYvg---sPKGITVKAYGKVSQAMIDMe-pGH 75  Thermoplasma ac...
ZP_01709708    4 FTIKENIMEsrdVNTLTFEDDi----kIKPGQFIMAWApRINYIPLSFSSvs---qIKSITVKIYGEASAYLAGLk-pGE 75  Ferroplasma aci...
Feature 1                                   #                                                    
P58886        76 SFGLRGPFGKGFTLpsrGEKVLLIAGGVGAAPLSPYAEAAsaagaeVHTILGARSAg-DLLFEWRFea------lgDIYA 148 Methanosarcina ...
O29722        73 YVGVRGAFGSAFTP---SKRALIVAGGIGIAPMKYLYEYLmkcgskVSVVYGERTAk-NLFWLDKFd---------RITV 139 Archaeoglobus f...
P58887        84 VVWVRGPYGKPFEVr--GSRAVVVAGGTGVAPLVPLVERLrrarvhVTSVLGGPHAd-RLPRKDDLekl-----sdELYV 155 Methanopyrus ka...
YP_920561     82 YVFVRGPLGRGFRLd--ARKALLVGGGYGAAPLLYLAERLsgagatVHAVLGFRSRe-HALLVEDFrrv-----agEVWV 153 Thermofilum pen...
YP_001582723  87 QIGIRGPYGNSFDLk--EGKLLLVGGGTGLVPMMRLLTHVkpt-ddITVLIGAKSK--DEVFFEDLanrllennphKVIV 161 Nitrosopumilus ...
ABK77188      77 LIGVRGPYGRAFEAt--QGRALLVGGGTGMSPLMRLLSRLgsa-shVDVLIGAQTE--KEVFFEGLagrlagdvphRIVV 151 Cenarchaeum sym...
YP_448434     91 LIGIRGPYGHGYELd-gYKKVLAVGGGSGIASLAPLTSFYd-----NVELISASSCadELVFNKRFds------dvVVHK 158 Methanosphaera ...
CAJ74952      81 QIGIRGPYGMGYGLpenNAVTCIVGGGIGMASIACLADMQk----nTTIIQGARTMp-ELLFQHRFr---------EMKL 146 Candidatus Kuen...
Q9HL36        76 EFYIRGPYGNGFQIe--SGRKLIIGGGSGIASLLPIADSD------TDALISAKTKe-ELIFTDRFpe-------sRLFI 139 Thermoplasma ac...
ZP_01709708   76 KLFYDGIYGNGYDAv--PGKKLLIGAGSGIASLIPLIDEN------TTGIISGKTKt-DILFRSKFkk-------eKLHI 139 Ferroplasma aci...
Feature 1                                                                   ##                   
P58886       149 STDDGSkGVKGFVTDVLKgld-vaaYDRIAVCGPEIMMASVFRLLEERKvlekAEFSLHRYFKCGIGVCGACCIDlsGLR 227 Methanosarcina ...
O29722       140 TTEDGSfGLKGTVLDALKlek-ldeYEKIYVCGSEGMLRATYDFLKERDaldkAEFSLERYMRCGIGVCGSCVIEn-GLR 217 Archaeoglobus f...
P58887       156 TTEDGSeGRKGFPTDVLEelvekecPDVVYACGPEGMLVRVAEIAREHDv--pCQVSVVRYVKCGEGICGSCALGk-GLL 232 Methanopyrus ka...
YP_920561    154 ATEDGSeGFKGTAVDLFErvfpgggYDAVYTCGKELMMEKVVRRAVEAGv--rVQASLERIIKCGVGVCGACALEplGLR 231 Thermofilum pen...
YP_001582723 162 STDDGSyGEKGFVTDLVEkhvdqikFDGVYVCGPEIMMYKTVQSAHSRGi--fVQASLERMMKCGVGICGSCCVG--EDL 237 Nitrosopumilus ...
ABK77188     152 TTEDGSyGRQGRVTDELEgml-dekPDAVYTCGPEPMMHAVVRAADSRGi--pVQASVERVMKCGVGICGSCCMG--EDL 226 Cenarchaeum sym...
YP_448434    159 CTDDGScGFKGFSTQLAEellqtgeYDVIVGCGPEIMSYKLYELSIKYDv--dCQLALDRYMKCGLGICGQCCIDdtGLR 236 Methanosphaera ...
CAJ74952     147 CTDDGSfGYRGTTVDLLReltgqhnYKKIYACGPEKMLYKIFELCNERHi--dCEVSIERYIKCGFGICGQCDCS--GQR 222 Candidatus Kuen...
Q9HL36       140 ATDDGSeGFHGFPHEFLDrld-isvYRKIYVCGPEPMLYRVMQKLASMNa--rAEFSLERTMKCGIGICDSCSVG--GLQ 214 Thermoplasma ac...
ZP_01709708  140 VTDDGSmGKKGFVATAMDeld-iesFDMIYVCGPEIMMFSVLNYLKGMKv--nCQFSLERSMKCGIGLCDSCSIN--GFQ 214 Ferroplasma aci...
Feature 1                      
P58886       228 VCKDGPVFSGIQLL 241 Methanosarcina acetivorans
O29722       218 VCADGPVFNASELP 231 Archaeoglobus fulgidus
P58887       233 VCRDGPVFWTEELE 246 Methanopyrus kandleri
YP_920561    232 VCSDGPVFDGETLL 245 Thermofilum pendens Hrk 5
YP_001582723 238 VCKDGTVFDGQHLS 251 Nitrosopumilus maritimus SCM1
ABK77188     227 VCTDGAVFDGKHLI 240 Cenarchaeum symbiosum A
YP_448434    237 VCVEGPVFNKNQLR 250 Methanosphaera stadtmanae DSM 3091
CAJ74952     223 ICIDGPVFNAEALG 236 Candidatus Kuenenia stuttgartiensis
Q9HL36       215 VCRQGPVFDIEQLR 228 Thermoplasma acidophilum
ZP_01709708  215 VCRDGPVFSIEKLK 228 Ferroplasma acidarmanus fer1

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