Conserved Protein Domain Family
DHOD_e_trans_like1

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cd06219: DHOD_e_trans_like1 
FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as NAD binding. NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group, as in flavoenzymes, or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD, forming FADH2 via a semiquinone intermediate, and then transfers a hydride ion to convert NADP+ to NADPH.
Statistics
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PSSM-Id: 99815
View PSSM: cd06219
Aligned: 39 rows
Threshold Bit Score: 235.163
Threshold Setting Gi: 156719283
Created: 6-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                # ####             ###   ###           
Q9X1X4        7 NEIVKKVKIaedVFDFWIHSpSVSKEARPGQFVVIRLHEKGERIPLTVADtkpeeGLFRMVVKVVGKTTHELSLKk-eGD 85   Thermotoga mari...
YP_307231     2 YTIIERQDLlpkVHLLKIQApKVAAAAAAGQFVILRVDTEGERFPLTIADwdaqaGTVTVIYMEIGVSTRKLAKLg-kGD 80   Dehalococcoides...
BAG13793      2 YKIISKKEIgpkVRTYEICApEIARNAKAGQFVIFRIDDKGERVPLTVAGtdpqkGLVRIIFQEVGKSTMQLASLc-eGD 80   uncultured Term...
NP_950056   651 QTIVGKVPLaggIVEFTVRApMVARSAKAGQFVRVLPWEKGELIPLTLADwdaekGTIDLVVQGMGTSSLEINRMa-iGD 729  Rhodopseudomona...
YP_524448   654 QTILQKIHLadgIVEFIVHSpLVAKAAQAGQFVRVLPWEKGELIPLTLADwdakaGTICLVVQAMGASSIAINAMl-vGD 732  Rhodoferax ferr...
ZP_01867583 619 AKIVKRRQLtdeIVEFTITApLIARSAKPGQFVRVLADEKGELIPLTLADwdaekGTIELVIQGLGSSSKLINRMq-eGD 697  Vibrio shilonii...
YP_843342     2 YRICEKEVLapnIIHMCFEApRIAGAARPGQFLIVRVDERGERLPLSLAGwdpekGTVDVVFYVLGTSTMKLASLk-eGD 80   Methanosaeta th...
BAA30996     11 YKILEKKEIamrNTWYKIYApHVAKKVQPGQFVIVRAFPNGERIPLTPIMwdreeGWIVLVAFTKGKTTMKMAMElkeGD 90   Pyrococcus hori...
YP_846268     2 FPIVLHEELspgVHRMSVKApEVARKCGPGQFVIVIIDEKGERIPFTVSGwdtaaKTVDFVYVEVGKSTRQLAGLk-pGD 80   Syntrophobacter...
NP_142805     6 YKITDKRDLspiDFFVEVEApHIAKAWKPGQFVIFILHERGERVPMSVYKae--nGRIGMFIRKLGKTSLQLYYEfnvGD 83   Pyrococcus hori...
Feature 1                                     #                                                 
Q9X1X4       86 TILDVVGPLGNPSEIen---yGNVLLVGGGVGIA-TLYPIAKALKeAGNNITTVLGARTkDYLIMVDEFke--------- 152  Thermotoga mari...
YP_307231    81 AILDFAGPLGKPTEIen---fGTVVCVSGGFAMA-TIVPIARAMKeAGNRVISIVGARSkDLFFWHDRLtky-------- 148  Dehalococcoides...
BAG13793     81 CIKDFAGPLGRPTEIkk---yGTVVAVAGGVGTA-EVLPVIKELKqAGNRIITVVGARCkDLIILEDELkre-------- 148  uncultured Term...
NP_950056   730 AFSGIAGPLGRASELhryegnQTVVFCAGGVGLP-PVYPIMREHLrLGNHVTLISGFRAkEFLFWTGDDervgklkkefg 808  Rhodopseudomona...
YP_524448   733 AFTGIAGPLGLPSELhrfegqQTVVFTAGGLGLP-PVYPIMRAHLrLGNHVTLIAGFRNaDLLFWVKAGervsqlqaefp 811  Rhodoferax ferr...
ZP_01867583 698 VFEAIAGPLGQASKVvvhqdnHRVYFTAGGVGLP-AVHPIMRAHLeIGNKVTLISGFRGaPQAFWTEQGdkvetlkalyp 776  Vibrio shilonii...
YP_843342    81 CVLNLAGPLGEPTEIsh---fGDVICACGCFGIG-PAIPLIKSLKdAGNRVVTVVEGRSrSFIFWEDRLrsl-------- 148  Methanosaeta th...
BAA30996     91 EILNVAGPLGNPAPMek---fGKILAIGAYVGIA-EVYPIAKAWQeIGNDVTTLHVTFE-PMVILKDYFeka-------- 157  Pyrococcus hori...
YP_846268    81 NLAHLVGPLGRAAEIdr---fGHVVAVASGYGIA-AIVPVLDALRaKGNRVTTILQAPDvERIFGRSALers-------- 148  Syntrophobacter...
NP_142805    84 EFYSMVGPLGKPIKVky---yGNVVFASDAVCGQaENYATLKAMKeVGNYTISIQTFENaENVYPEEFLakp-------- 152  Pyrococcus hori...
Feature 1                                                                                       
Q9X1X4      153 -isDVLLVTDDGSa----------GMKGVVTdamdklf------rerkfdiCWAVGPTIMMKFCTLKarefgvpIWVSLN 215  Thermotoga mari...
YP_307231   149 -sdEMIVCTDDGSa----------GIKGLVTeplrdlls-----sdtkldrVIVIGPSVMMKFCSKTtqpfgvkTIVSLN 212  Dehalococcoides...
BAG13793    149 -sdLLLFATNDGTl----------GIKGFVTavlkdvi------srekidiAYAIGPVPMMKAVAELtmlkrikTLVSLS 211  uncultured Term...
NP_950056   809 dqlSLIYTTNDGSy----------GVKGFVTgpleemmkanqegkgrsiaeVIAIGPPLMMRAVSDLtkpygvkTVASLN 878  Rhodopseudomona...
YP_524448   812 dllDVIYTSNDGSf----------CQKGFVTtpleamlkdgqtsqgrkiaeVVTIGPPLMMRAVSDLtkpygvkTVASLN 881  Rhodoferax ferr...
ZP_01867583 777 dllEVIYTSNDGSf----------GVEGFVTnplkdrldehqagqgepiaeVITIGPPLMMRAVSDLtleykveCVASLN 846  Vibrio shilonii...
YP_843342   149 -sdKLHVVLGDGSc----------SEPGWANefisryls-----egnrvdrIFVHGCPFMMMVVSEAsrpfgvkTVVSLT 212  Methanosaeta th...
BAA30996    158 -vsRHIVEPVKIDqeksfqentknVTKALTAkvkelld-------nenwdlVFMVGPPGDQKAVFEVvkkygipMKVDLH 229  Pyrococcus hori...
YP_846268   149 -sdRLILAAGENGp----------DMTASATfplrrllad---hrgspvdrVIVMGSICLMRIISEMtrpygvrTMVHLT 214  Syntrophobacter...
NP_142805   153 vadEHYLTTEDGSv----------GIKGHYLdivkeli------ekdkvdiIFAGGKLGSLAKLAELtrpygipTYATVR 216  Pyrococcus hori...
Feature 1       ##                                       
Q9X1X4      216 PIMVDGTGMCGACRVTv----sGQIKFACVDGPEFRGEEVD 252  Thermotoga maritima
YP_307231   213 PIMIDGTGMCGCCRVSl----dGQTRFACVDGPEFDGHKVD 249  Dehalococcoides sp. CBDB1
BAG13793    212 PIMLDGTGMCGACRVSi----gGKMKFVCVDGPEFDAHYVN 248  uncultured Termite group 1 bacterium phylotype Rs-D17
NP_950056   879 SIMVDATGMCGACMVPvtidgkMVRKHACIDGPEIDAHIID 919  Rhodopseudomonas palustris CGA009
YP_524448   882 SIMVDATGMCGACMVPvtidgkMVRKHACVDGPELDSHIID 922  Rhodoferax ferrireducens T118
ZP_01867583 847 SIMVDATGMCGACMVPvmedgkLIRKHACIDGPEINSHVID 887  Vibrio shilonii AK1
YP_843342   213 PLMVDGTGMCGACRVEv----gGETRFACVDGPDFDGHLVN 249  Methanosaeta thermophila PT
BAA30996    230 PIMVDGTGMCGACRVTv----gGEVKFACVDGPEFDAYLVD 266  Pyrococcus horikoshii OT3
YP_846268   215 PLMVDGTGMCGACRLSv----dGNNRFACVHGPEFDGHKVT 251  Syntrophobacter fumaroxidans MPOB
NP_142805   217 QIMVDGTGMCGSCRILy----dGEVKFACRDGPVFDAHKVD 253  Pyrococcus horikoshii OT3

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