Conserved Protein Domain Family
FNR_iron_sulfur_binding_3

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cd06217: FNR_iron_sulfur_binding_3 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap between the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99813
View PSSM: cd06217
Aligned: 22 rows
Threshold Bit Score: 244.098
Threshold Setting Gi: 170781913
Created: 28-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts primarily in N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              #                ####             ### #   
YP_001509835  16 WRVARLAEVRDETPTARTLVLDVPGW-----PGHLSGQRVDVRLtaaDGYSt--rRSYSLAAPGAgd-rVELTVQRVpGG 87  Frankia sp. EAN...
BAC50081     293 KGKLRICAIYQETPNVKTFRLQAPDGga-ipFAFLPGQFLTYAIe-iDGQAv--rRSYTIASSAAqtayVETTIKREdGG 368 Bradyrhizobium ...
ZP_01109870  299 SGGMVVTAIFNETHDVKTLRLASPDGkt-ipFDFEPGQFVTFTLn-iDGFEkpvkRSYTIASSPTeqyyFEVTIKREeFG 376 Alteromonas mac...
YP_001173835 389 VGKLRVARVFQETPKVKTFRLAPVEGvgalpFEFEPGQFLTLSVh-sGGNQv--kRSYSIASSPCchgwCDLTVKHEsGG 465 Pseudomonas stu...
ZP_01854726   16 LISLPVTKVIQEADDVCTFRLDNSQGl---iPPHQPGMFVKVCLd-iNGVEv--wRSFSISSSPHqrerIDLTIKRNhAG 89  Planctomyces ma...
YP_119303     44 RLQLVVAEIVDETTTTKTFRMQGLDQav--lPPFLAGQYVNVFV---AGTS----RPYAISSSPTqrghYDLTVRRVpGG 114 Nocardia farcin...
YP_001535952  52 KLELTVTELIDETSTTKTLRLRRAAGgs--lPPFRAGQYLSLDVqvgDIHTn---RAFSISSSPTrrdhYDLTVRRLpGG 126 Salinispora are...
ABZ93397      54 RIHLRVESIRIDTPSTKTLVMVPVDGnr--lPPFQAGQYINLFVt-lAGVLt--aRPYSISSSPKnlqsYELTIKRAeGG 128 Leptospira bifl...
YP_001535968  45 QLDLVVDEVITETATTKTFRLRRATGel--lPPFQAGQYISLRLq-iEGVRt--sRAFSVSSSPTerrhYDLTVRRVpGG 119 Salinispora are...
EDQ13704      48 RLNLTVRRIIRETGTAVTLRLARSDGem--lPPFQAGQYVNLFVt-vDGTHt--aRPFAISSPPQirthYDITVREVpGG 122 Phaeobacter gal...
Feature 1        ###                                        #  #                                 
YP_001509835  88 EVSPYLTEIFsVGDPVEIRGPIgGWFVWRpa-dpEPVLLVAGGSGIVPLMAMVRARRSAasrVPFRLICSVRSpaDLYYA 166 Frankia sp. EAN...
BAC50081     369 LLSDYMHGHLkEGDLVEVAGPS-GAFTFTgv-eaDSVVLIGGGVGITPLMAAIRYLSDIawpGQIYLVYGAQTteQFIFR 446 Bradyrhizobium ...
ZP_01109870  377 VVSRYMHDAVeVGNTLSIKAPG-GKFYFNgh-gaNSVVLISGGVGITPMMSAVRYLTTTcwdGDIYFLFCTRTsnDFIFE 454 Alteromonas mac...
YP_001173835 466 IVSGYLHEQVkEGDLLDASGPY-GRFTFRgv-esDSVVFLGGGVGITPLMSSIRYLTDQswnGRIDLVYACKDleSVIFR 543 Pseudomonas stu...
ZP_01854726   90 QVGNYFFDHIhVGSHVFLKGPL-GQFHFDpaqhvEPVILLCAGIGITPMMSIVRYLHATnvnRICYLFYGARThrDIIFD 168 Planctomyces ma...
YP_119303    115 RISNLLIDTVvVGQVLTTTGPM-GTFHHNplfhgNDVVFLAGGSGVAPAMSMLREIADLgldRSLHLIYGSRHasDVIFH 193 Nocardia farcin...
YP_001535952 127 LVSNYLLDEVsIGDRFTSGGPM-GTFTHDplfhgDDLVFLAGGSGVAPAMSMIREIVELglpRRMTLLYGSRRsdDIIFQ 205 Salinispora are...
ABZ93397     129 FVSPYLLDDVkIGQKFESTGPM-GSFHHNplfhgFDIVFLAGGSGIAPAMSMLKAFLAAenpFRFHIIYSNSYenDVIFL 207 Leptospira bifl...
YP_001535968 120 RVSNHLLDAVaPGDRLVSSGPI-GTFQHNplfhgEDLVFLAGGSGVAPAMSMIREVVDRglpRTLHLVYGSRRadDIIFR 198 Salinispora are...
EDQ13704     123 FVSPYLVRGLtEGQLLQSSGPM-GTFYHNplfhgDDLVFLAGGSGVAPAMSMIHDFLSSarpPRFHLIYGSRNtgDVIFR 201 Phaeobacter gal...
Feature 1                                                                                        
YP_001509835 167 DELREAaradpGLDVTRCYTRvvPDHWTSPPRRLRpadlaeagwppdltpTCYVCGPTGFVEAVADALVEIGHepERIRT 246 Frankia sp. EAN...
BAC50081     447 DELEYLqrrmsNLHVAATMVRaaGTSWMGSEGQITaefltqa-vpdlarrRVHLCGPPGMMDALRKTLIGLGVprEQIKT 525 Bradyrhizobium ...
ZP_01109870  455 QELKYLqarhpRLKVLVSMTQaeGTSWMGPQGRFSsaminef-vpdiaskTAHICGPPAMMDATKKMLAELGMpdTHIKT 533 Alteromonas mac...
YP_001173835 544 DELNQLarrhpNLHVSIVLSDesSAAWTGPRGFITaellgqi--pqirsrRIHLCGPSVMMDAVRNELGKLGIdlASVHS 621 Pseudomonas stu...
ZP_01854726  169 QETRDLitempDFHYFLTLSQp-VPHWLGYCGQLNfdfmisk-ipqvelsRFFLCGPRNFNQDFTLRLLEMGVphELIHS 246 Planctomyces ma...
YP_119303    194 AELDALaaaqpGIRVDHVIAEp-DADWAGATGFLTadtiatl-ageldgrMVYVCGPQALYPYALDQLTALGHprKRIRF 271 Nocardia farcin...
YP_001535952 206 DELEAIerqhpNIVVHHILAQa-DPGWTGAVKPLNaplivkl-aaplagrMTYVCGPAYKYPYLVGELESLGLpgRRIRM 283 Salinispora are...
ABZ93397     208 DELRNLsllhkNFILTEFISRevSPEFKGFKGRLDivtlqtl-lsdvsskMFYVCGPTPFNEHCANLLADLGVksGRILI 286 Leptospira bifl...
YP_001535968 199 AELDQVardcpEITVDHVISEp-DADWSGPTGFLSaavverl-agplrgrMTYVCGPPAMYAYQLRQLDRVGHprRRVRL 276 Salinispora are...
EDQ13704     202 EQLHQLadrheSLTIDEVISEp-DADYSGHSGFLNadliakl-vgplegkTFYLCGPNAMCDFCQPELTKLGVseRKVHV 279 Phaeobacter gal...
Feature 1        # #
YP_001509835 247 ERF 249 Frankia sp. EAN1pec
BAC50081     526 EAF 528 Bradyrhizobium japonicum USDA 110
ZP_01109870  534 EAF 536 Alteromonas macleodii 'Deep ecotype'
YP_001173835 622 ELF 624 Pseudomonas stutzeri A1501
ZP_01854726  247 EQF 249 Planctomyces maris DSM 8797
YP_119303    272 EAN 274 Nocardia farcinica IFM 10152
YP_001535952 284 EAN 286 Salinispora arenicola CNS-205
ABZ93397     287 EGN 289 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)'
YP_001535968 277 EAN 279 Salinispora arenicola CNS-205
EDQ13704     280 EAN 282 Phaeobacter gallaeciensis BS107

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