Conserved Protein Domain Family
FNR_iron_sulfur_binding_2

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cd06216: FNR_iron_sulfur_binding_2 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99812
View PSSM: cd06216
Aligned: 32 rows
Threshold Bit Score: 246.753
Threshold Setting Gi: 93004974
Created: 23-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts primarily in the N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              #             ####        
YP_001158905  39 LPDDYLDLIAPLRAGtdLRGRIVEVRPETPDaATVVIQPGRD----WQGHRPGQYVRLGVDVNGVRqWRAYSVTSapgd- 113 Salinispora tro...
ZP_01307362   30 FFEPLIQWIKPNWRAdrCYTRVVSVRYESSDmYTLQLKPLQS----FSHEFAGQYVELIIQKDGAWvSRYFTISSspeff 105 Oceanobacter sp...
ZP_01132476   24 YLEPLVQQFKPAWRAgfYRAKVIKIITLPANcISLELRPERS----WPSHQAGQHVLLSCQFNGRLmTRTFSISSsqgqa 99  Pseudoalteromon...
YP_001186168  32 DVDLCLRLLHPALRLnrVFAQVEARRWVADDmLAIELRCNGN----ARDWRAGQHVQLYLEQDGVRhGRSYSLTRvtd-- 105 Pseudomonas men...
ZP_01643509   33 LFDFWAGQLNPLWTLrePVARLVRREPAGEGaATLVLRTNRH----WAGMRAGQHVTLGVEIEGRLwQRSYSPTAlg--- 105 Stenotrophomona...
NP_639219     32 LFDFWATRINPLWTLerPMARLVARTPASRDaVTLLFQPNGH----WQGLQAGQHVSIGVEIDGRRlLRSYSPTVla--- 104 Xanthomonas cam...
ZP_01916139   59 FVTFWLEQAGSTHSTdrCLAEVVRIDRETADaVSLWLRPNAL----FKGFEAGQHVNLSITIDDVVhTRSYSFSCapt-- 132 Limnobacter sp....
AAG08274      29 DVDGLLRHAHPLASLnrHYARVEARYWVADDmLALALRTAPG----WPPVRPGQHIQLLAERDGVRvGRSYSLTRvv--- 101 Pseudomonas aer...
ZP_01612299   22 YIEPIMQVFKPAWRAgqFRAQLMSSESLNGEfLSLQLKPSKQ----WPAHTAGQHVSLTIEMNGRLlTRVFTVASsvkyf 97  Alteromonadales...
ZP_01896398   22 YFSPFSTKPVAVLMGdmFAAKVVAIKPENNDmYSLTLAVSGKvnaqSFSFQPGQYVELQVKKNGSYvKRPFTISSplaql 101 Moritella sp. PE36
Feature 1                ### #   ###                                              #  #           
YP_001158905 114 -rhdPITITVKAIpdGLVSNHLVRHAqPGTIVQLDQAQGDFVLPAt--------pPARVLLVTAGSGITPVMGMLRSGal 184 Salinispora tro...
ZP_01307362  106 retgTIELSIAIQanGRITPWLMKNLnKGDMVNLGQPMGDFLPLNipr----dksVSRKVFIAGGSGITPFRSSLQSLmq 181 Oceanobacter sp...
ZP_01132476  100 ergnHIRLTIKTAknGAFTSQLANELaVGDFVNLSEPMGEFLLPScep-----nsTDELFFIAAGSGITPFMAMLHTLae 174 Pseudoalteromon...
YP_001186168 106 --dgRIELAIKRQpgGRLSNRLLDHLaVGEVIELGQAFGDFAWPQe---------QGAVLLLAAGSGLTPLLGLLRDAla 174 Pseudomonas men...
ZP_01643509  106 --rrELAITVKAIdgGRVSQHLVNHAqPGELFRLDAAFGEFQLPA----------AAPVLLLAAGSGITPMRSLLREAcq 173 Stenotrophomona...
NP_639219    105 --dgRLAITVKAItgGLVSTYLAGEApLGAVVSLDPAFGDMLLPTt---------PAPLLLLAAGSGITPMRALLQAAaa 173 Xanthomonas cam...
ZP_01916139  133 -dsgLVRLTIKQTptGLVSRYVVNQLeVGAVVELGDVFGDMTLAHtqsn--lsaqRPTMLLLAAGSGITPMISLIEELea 209 Limnobacter sp....
AAG08274     102 --geRLEIAVKRHpdGLLSPWLCEHLaVGQRVELQPAQGDLRWPMq---------AEAVCLLAAGSGLTPLLGLLREAle 170 Pseudomonas aer...
ZP_01612299   98 netgFIRLLIKTSeqGRFTGLLNNKAkAGTWCNISAATGEFVFKNt---------HTPATLIAGGSGITPMIAMLDDYla 168 Alteromonadales...
ZP_01896398  102 qqdkTITLTIKKQskGRITPWLADAVeKGDLFGISPAKGDFLLSAallhsankqeNKDVIFIAGGSGITPFHSLLMSHva 181 Moritella sp. PE36
Feature 1                                                                                        
YP_001158905 185 t----gsDVTLVHSAPTAaDVIFGGALRELa-gAGALRLVERHtr--------ddGQLSLADLAALVPDHle-------r 244 Salinispora tro...
ZP_01307362  182 sderdtqEIELFYYARSEeHFLFREELQRCa--YLLPKAHVHFmds------ekiGFFDYTHLQVENKHQtd-------t 246 Oceanobacter sp...
ZP_01132476  175 rdhirtqNIYLCYFAKQG-EHLFIDELTELkrfIPRLNVMFLVrk---------qGDSLASALKNVMPTSq--------- 235 Pseudoalteromon...
YP_001186168 175 rg--faaPVTLLHQVRRQgQQAFAEELQALaarHANLQVRWAFsge-------agGRLTAAQLAALPGEH---------- 235 Pseudomonas men...
ZP_01643509  174 rp--laaPVDLFYWERTAaHLQFRDELQALaaaHPNLRVHLLTtr---------eGEAPAARIDTHDLLVpgddtplaqr 242 Stenotrophomona...
NP_639219    174 ag--mpmDVDLLYWVRQRdEACFLDEFEALaaaHPRLRAQLLTtr---------eGAAPAPRIDSFPLEQvtal---qdr 239 Xanthomonas cam...
ZP_01916139  210 kg--wpaDVTLMSWARNPeDVLFDTSLKAKa--NEHFKYVRLLesganlaegdlaGRPSAEQFAAVAGALet-------t 278 Limnobacter sp....
AAG08274     171 ng--yrgPVLWLHYVRHPgQRAWLGELEALaarHPNLELRWSLtrgara-dgcleGHFQPRHLDGWAADLar-------s 240 Pseudomonas aer...
ZP_01612299  169 q---ttkAINLVYYAKSG-EHQCVDELRELatqFSNFSFLLLT------------REQSSDITSNIKHWEnp-------- 224 Alteromonadales...
ZP_01896398  182 nn--ptiNFTLLYFVRAN-QHVLSDTLVALeleHANFTLKLLHse--------rdGYCSKAHINAITSELnd-------c 243 Moritella sp. PE36
Feature 1                                      # #
YP_001158905 245 eTWACGPAGLLDALTAHWTAVGrg-eRLHTEQF 276 Salinispora tropica CNB-440
ZP_01307362  247 aFFVCGPPAMIQHVRSTLNTHGvkkeNIYYEFF 279 Oceanobacter sp. RED65
ZP_01132476  236 -VLICGPQQFKQDVDAVLNHFGhlslNRQAEFF 267 Pseudoalteromonas tunicata D2
YP_001186168 236 -LLLCGPRGFVEQACGWWRDAGrg-gSLQAESF 266 Pseudomonas mendocina ymp
ZP_01643509  243 hVLACGPDGFVAAARERLAHQVa---GFQAEAF 272 Stenotrophomonas maltophilia R551-3
NP_639219    240 hVMACGPGGFVQAARARLQDRVa---RFQAEAF 269 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_01916139  279 dVYACGPDGFMNALRGILGDTPk---SFHAESF 308 Limnobacter sp. MED105
AAG08274     241 qALACGPAAFVEAVGEQLGARFa---GLQTESF 270 Pseudomonas aeruginosa PAO1
ZP_01612299  225 dIYCCGPLGFMQRVQAFAQKHDl---NYYQEAF 254 Alteromonadales bacterium TW-7
ZP_01896398  244 aVYICGPNSMMDSTQTLLLDMGlaqdAIHLEQF 276 Moritella sp. PE36

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