Conserved Protein Domain Family
FNR_iron_sulfur_binding_1

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cd06215: FNR_iron_sulfur_binding_1 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal portion of the FAD/NAD binding domain contains most of the NADP(H) binding residues and the N-terminal sub-domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. In this ferredoxin like sub-group, the FAD/NAD sub-domains is typically fused to a C-terminal iron-sulfur binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins which act as electron carriers in photosynthesis and ferredoxins which participate in redox chains from bacteria to mammals. Ferredoxin reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99811
View PSSM: cd06215
Aligned: 35 rows
Threshold Bit Score: 267.919
Threshold Setting Gi: 87122003
Created: 23-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts primarily in the N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                  ####                ### #   
NP_521624    36 LVCCHVRQETHDVKSFFFRSPAGr-tFLFEPGQFITLE-LDIEGEti----nRCYTLSSSPARPh---tISITVKRVpgG 106 Ralstonia solana...
NP_936465   328 LTCVEKEAIARDFVTFWLEPEHGq-lPAYLPGQHLPVE-ITVDGDti----sRRYTLSSSPSRPg---rYAISVKRIdgG 398 Vibrio vulnificu...
ZP_01158515 270 LTCVKREIIAKDFVSFSFKAQKDtalAPYLPGQYLPIR-IAINGNvv----eRCYTLSSSPLEQe----YTISVKRIeqG 340 Photobacterium s...
ZP_00378705  47 VECVSITEVTHNVKSFELFAPWLa-rIDFEPGQYVTVRiPELELE-------RCYSIASAPFGTn---tFTLTVKRVdaG 115 Brevibacterium l...
YP_856033   338 LVCVAREPLARDLETFWFEAADGeplPDYLPGQHLPIS-LDIGLGlrrerlqRRYTLSSTPERPe---rYSISVKKVggG 413 Aeromonas hydrop...
NP_992602    34 MQVHSIVQETPDVWSLRLINHDF---YSYLPGQYALVS-IRNSDEt-----lRAYTLSSTPGLSp---fIQLTVRCLpdG 101 Yersinia pestis ...
ZP_00133729  14 LQVYSIVQEAPHVKTINFIAQDF---YPYQAGQYALVS-IKNTPHi-----tRAYSLSSTPGESr---fVSITVREIegG 81  Actinobacillus p...
YP_928506   285 LRLITKEPIAKDFMGLSFEAADGkplPTFLPGQHLVFA-FDINGTrh----iRRYSLTHAPSEGn----YHIGVKRTrdG 355 Shewanella amazo...
ZP_01077888 376 ATLVKIVEETETVKTFRFVVSQR---IAFLPGQYASFEfNNILGGaas--evRTWTLSETPNSLkgdntLDISVKRVpnG 450 Marinomonas sp. ...
ZP_01873936   3 LRVSEIIEHCPTIKTFCLEPLEEy--KKYFAGQYLTVH-TGEEGDv-----lRPYSLSSSPTNSg---sYEISVKLIegG 71  Lentisphaera ara...
Feature 1       ###                                              #  #                           
NP_521624   107 KVSNWLHDNLqPGAAIRVLGPaGEFTCARhp--------aRKYLFLSAGSGVTPLMSMSRAHHDlae-------drDIVF 171 Ralstonia solana...
NP_936465   399 RVSNWLIDHLeVGDELFAQSPqGQFHIQEdk--------hQPLLLLSAGSGVTPMLSMLRYLADhdl-------veDVVF 463 Vibrio vulnificu...
ZP_01158515 341 TVSNWLHDNLqVGDTIWSEKPsGQFYLEPhk--------qQNTLLLSAGSGVTPMMSMLRSLISern-------tqGLTF 405 Photobacterium s...
ZP_00378705 116 AVSTHLHDVLkVGDRIHVDGPyGLFSTSFhp--------aEKHLFVSGGSGISPIMSMVRSLLArpag-----tptDIVL 182 Brevibacterium l...
YP_856033   414 RISHWLHQQLqPGDRLLAAAPaGEFHLGTg----------RSLLLLSAGSGVTPMLSIARTLALrge-------lgDVHF 476 Aeromonas hydrop...
NP_992602   102 EGSRWLTQQVnVGDYLWLSDAqGEFTCANad--------dDHYLMLAAGCGVTPVISMCRALLAqrp-------qaDIRV 166 Yersinia pestis ...
ZP_00133729  82 VGSTWLNNEVkVGDQVWFSNPmGEFSCQHvl--------aDNYLLVGAGSGVTPIMSMARWLLAnrp-------kvNLTV 146 Actinobacillus p...
YP_928506   356 LISNWLHDELtVGDTVLCSRPeGRFIPKAg----------YPLLLISAGSGVTPMLAMVRTALAlgklkgvslplaHIHF 425 Shewanella amazo...
ZP_01077888 451 LVTNWLHDHAeLGLELVLTGIqGEMTAITldadtqtplvpEQLLLLSAGIGITPNLAMVRGIGAfslq-----dktKVTM 525 Marinomonas sp. ...
ZP_01873936  72 LGSTWMHTQVkVGDELLCDEPeGKFTLQQa---------aLTSVFVAGGIGVTPVLSMLKYALSikd-------trKLLF 135 Lentisphaera ara...
Feature 1                                                                                       
NP_521624   172 VHSARTPDDIIFARELELIasn-htNFRTSFVVerlgart-nwpgitGFLSLPLLKLIAPDFmeREIFTCGPApYMKAVR 249 Ralstonia solana...
NP_936465   464 YHQCRSVEDIPCKEELDALksr-ypGLTVKISLtqapid---wfglkGRLSLSHLKQIKAVEs-RQVFVCGPEgFMQKAK 538 Vibrio vulnificu...
ZP_01158515 406 YHYCKTQADIPFADELAEIqrh-hpEISIHICLtqdndt---shayhGRICAEHFANIDVKDn-CHVYVCGSSgFNQIAQ 480 Photobacterium s...
ZP_00378705 183 IHNAATVDDIIFRPELEQLae--vpGVSVVTMCsrdcaae-vwagrrGRITSQSFAEVVPELrdRETFVCGPGgYMAAVR 259 Brevibacterium l...
YP_856033   477 MHLCRSEADIPAAGELHALaq---qGMTLTLILsqpdth---wqglkGRLGDDHLKQVKQLAe-REVFICGPHgFMADAA 549 Aeromonas hydrop...
NP_992602   167 IFNVRTPADVIFANEWHTLlqrypqQLKLTLMAesaat----agfieGRINARIMQQVAPDIahRRVMTCGPApYMAWVE 242 Yersinia pestis ...
ZP_00133729 147 IHSVHSPEDVIFKSEWQELkak-ypQLNLVMNAsvgat----egfasGRISAEIIKNAVPNVsdYTVMTCGPEaYMAALK 221 Actinobacillus p...
YP_928506   426 IHQCRSEDDIPCHKSLEDFva---aGMTLELNLttpgie---wkgnqGRVSASQLAAVPLLAe-RDAFICGPSgFMQTVE 498 Shewanella amazo...
ZP_01077888 526 IHVERYQRHLLSHHELVRRshk-ypDFSYTNIIts----------eqGRLTKAQLEALVPNPkeQQAYVCGPAlFMAQMT 594 Marinomonas sp. ...
ZP_01873936 136 FYASRHLEDLVFHQELLDLaa---aHPNLIYVPiisgdqdpewqgqrGRVNKELLEDTGVIFkrAEFYTCGPDaMMKNLE 212 Lentisphaera ara...
Feature 1                      # #
NP_521624   250 GLLEEAGFdpARYHEESF 267 Ralstonia solanacearum GMI1000
NP_936465   539 NLLLKKGLpeSHYHQEAF 556 Vibrio vulnificus YJ016
ZP_01158515 481 ELFSNQGLptDRFHQEQF 498 Photobacterium sp. SKA34
ZP_00378705 260 LMLDELGVlgSRVHEESF 277 Brevibacterium linens BL2
YP_856033   550 ARLVALGVpaERIRQESF 567 Aeromonas hydrophila subsp. hydrophila ATCC 7966
NP_992602   243 QYCQQQQVpaDHFQQEQF 260 Yersinia pestis biovar Medievalis str. 91001
ZP_00133729 222 NIVLELGVseDRFFTEAF 239 Actinobacillus pleuropneumoniae serovar 1 str. 4074
YP_928506   499 GMLTQGGMvtSQIHCESF 516 Shewanella amazonensis SB2B
ZP_01077888 595 EYLASIGVpvANIHTEAF 612 Marinomonas sp. MED121
ZP_01873936 213 ELALANKVskSNFHKELF 230 Lentisphaera araneosa HTCC2155

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