Conserved Protein Domain Family
oxygenase_e_transfer_subunit

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cd06213: oxygenase_e_transfer_subunit 
The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD/NADH domain and/or discrete) to the oxygenase. Dioxygenases add both atoms of oxygen to the substrate while mono-oxygenases add one atom to the substrate and one atom to water. In dioxygenases, Class I enzymes are 2 component, containing a reductase with Rieske type [2Fe-2S] redox centers and an oxygenase. Class II are 3 component, having discrete flavin and ferredoxin proteins and an oxygenase. Class III have 2 [2Fe-2S] centers, one fused to the flavin domain and the other separate.
Statistics
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PSSM-Id: 99809
View PSSM: cd06213
Aligned: 12 rows
Threshold Bit Score: 357.006
Threshold Setting Gi: 162450113
Created: 28-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts lie primarily in N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #              ####               ### #   ### 
AAC45296     115 FAATIVATEPLTH--DILKVTIQTDrpVHYLAGRYANVRVPGwp---rfRCYSFANAPqrkgrnVLEFYIRKVPAGEFTE 189 Pseudomonas chl...
NP_049191    110 YRGTIVAAQRLCE--DIIGLTIELDrpLAFTPGQYADLTAPGie---gaRSYSFAFATvgeptqQLHFHIRHVPGGAFTD 184 Novosphingobium...
AAB70826     116 TSALIRKQKRLAH--DIVELELVSDkqIAFYPGQYADVECAEcs---avRSYSFATPPqp--dgSLSFHVRLVPGGIFSG 188 Pseudomonas putida
YP_557481    115 YTANIIATEPLTH--DILRVTVQTDraVSYAAGQYANLRKAGgg---raRSYSFANAPqrkgrtLLEFYIRKVPGGEFTE 189 Burkholderia xe...
ZP_01914094  122 TRGTIVGQKDLTH--DIVELRVALDdpMPFKAGQYAEIRLEEfs---lsRNYSFAMAPkgqeanELVFHVRKVPGGKFTE 196 Limnobacter sp....
YP_973211    105 VKGVVVGKQMLTH--DIARIDIRLDqpIRYRAGQFAEVALPAlpd--csRSYSFSTAPgn--drQVSFTVRRVPGGRVSG 178 Polaromonas nap...
YP_001188030 106 VEGRVVAQERLTH--DITRLLLQLDasLPYKSGQYANLAIEAlpg--vvRSYSFASPPqa--daKVSFFVRRVADGRFSS 179 Pseudomonas men...
YP_371981    106 IDGRVIGQDRMTH--DIVRLRVQLDesLPYKAGQYAQLSIASlpg--eaRHYSFATSVrp--naQVNFLVRKVPGGVFSG 179 Burkholderia sp...
ZP_01913733  106 VAGRIVKREFLTH--DIARIDVQLDqpINYKAGQFAELTLDSvkn--apRSYSFSNAPdn--qgLASFTIRRVPSGRFST 179 Limnobacter sp....
ABZ95196     116 ILGQVIRQKFLTK--EICEITIQLKipINFKAGQYVSLSIEGmd---aeRNYSIANAPne--kgIVSFIIRNVPGGKLSN 188 Leptospira bifl...
YP_001234391 116 ARASIAALDRMTP--DIMRLSVTLDapLAYTAGQYAELARPGde----aRQFSFIDPPsgpaatTARFFIRHVPGGAVTS 189 Acidiphilium cr...
YP_001612480 118 IDASVARVTRLAPsvLALEVDLASD--VRYVAGQYAQLTVPGvpglgepRCYSFAEAPdrasprRALFHIRHVPGGAFTG 195 Sorangium cellu...
Feature 1                                                #  #                                    
AAC45296     190 ALFrgeLDGQPLEMEAPQGTFHLHGGd----APMLCIAGGSGLAPLVSILEHARANRIKRDCILLFGARTEgDLYQLEAI 265 Pseudomonas chl...
NP_049191    185 WLFctdRTGMELKVTAPYGQFALKDSt----APILCIAGGSGLAPIISILEQALDRGADRAVHLLYGARRQsNLYALDKI 260 Novosphingobium...
AAB70826     189 WLFggdRTGATLTLRAPYGQFGLHESn----ATMVCVAGGTGLAPIKCVLQSMTQAQRKRDVLLFFGARQQrDLYCLDEI 264 Pseudomonas putida
YP_557481    190 SLFggeLKGVSLEMEAPLGTFHLRAGd----SHMVCIAGGSGLAPLVSILEHARGNRIKRDCTLLFGARTQaDLYQLDAI 265 Burkholderia xe...
ZP_01914094  197 WLFaanRQETRLSMSGPFGDFYLRPAegekpAPIVCVAGGSGMAPILSLLEQAKWAGETRDAVYLFGARTQrDLYADEEI 276 Limnobacter sp....
YP_973211    179 HLVdkaQVGESLTVRGPGGQFWMRPGq----APVLMVAGGSGLAPILAMLEDMKNRGDLRPVTLLFGARAQrDLYALDEL 254 Polaromonas nap...
YP_001188030 180 FVHehnLLGERVSLEGPLGDFWLRQGa----APLLLIAGGSGLAPILALLQEALASGVTRSLTLLFGAREErDLYALEEI 255 Pseudomonas men...
YP_371981    180 HVHahdLVGRTVSVEGPLGDFWMRPAd----APLILIAGGSGLAPILAMLEDGVAARTTRAVTLLFGARAQhDLYALDTI 255 Burkholderia sp...
ZP_01913733  180 YVFdklVEGEILTVRGPGGDFWLREGg----EKVVFIAGGSGLAPILGMLEEMERKGDRRPVTLLFGARTEqDLYELHRL 255 Limnobacter sp....
ABZ95196     189 YIFnenLVGKKTKVKGAFGNFYLRDSk----NPILMIAGGSGLSPILAILEQGILNGTKRPLTLLFGARKKeDLYKLNEL 264 Leptospira bifl...
YP_001234391 190 WLFeaaRPGDTLDLRGPFGDFWLRPGt----APIVAIAGGSGLGPVKAVLEQARADRVPRDAILIFGVRTRaDLYALDEI 265 Acidiphilium cr...
YP_001612480 196 WLFgadRTGARLCFSGPHGSFRYHEAd----RPLLCVAGGTGLSPIKAILEQGVSDGLARDVTLVVGARTRqDLYALDAI 271 Sorangium cellu...
Feature 1                                                                                     # #
AAC45296     266 GNIaanWQGEFRFIPVLSHEPehSDWTGARGLVTEHIpadf--cegaEGYLCGPPPMIDAAIARLLDNRLplEKIFYDKF 343 Pseudomonas chl...
NP_049191    261 AALrqrWMAPFEFVPALSDEEpdSDWAGARGLITEQIagvad-laahEAYLCGPPAMIDFAEAQLLAAGIsrSVISADRF 339 Novosphingobium...
AAB70826     265 EALqfdWGGRFELIPVLSEESstSSWKGKRGMVTEYFkeylt-gqayEGYLCGPPPMVDAAETELVRLGVarELVFADRF 343 Pseudomonas putida
YP_557481    266 GSIasnWQGDFRFIPVLSDEPldSDWKGARGLVTDHIapgf--ceggEGYLCGPPLMIDAAIASLAKHGIplEKVFYDKF 343 Burkholderia xe...
ZP_01914094  277 GRVqqgWRGSLSFKQVLSEEPanSSWNGARGYVTDELdkleldwpqvQAYLCGPPAMIDAAIAKFSKLGVkaENIRYDKF 356 Limnobacter sp....
YP_973211    255 AAYs-aSWPNFRFVPILSEADasQAWEGRTGLVTEHIpell--gsatSAYLCGPPAMIDSAVAVLRKQGItdEHLHADRF 331 Polaromonas nap...
YP_001188030 256 SAIaaqWRGPFRFLPVLSALPadAPWQGARGLVTEHLaqvl--epgaHAYLCGPPAMIDAAVAQLVRHGVarAHIHADRF 333 Pseudomonas men...
YP_371981    256 HDLaarWPGRFDFQPILSDEPadSSWRGSRGMVTDAIaadl--paqtHAYLCGPPRMIDAATDVLVARGLsrSRIHADRF 333 Burkholderia sp...
ZP_01913733  256 DAYt-kNWPGFRFVPILSEDNsnHNWNGLRGLVTDHIrrea--agatQAYLCGPPQMIDAAIKELKENKLaaQGIYADRF 332 Limnobacter sp....
ABZ95196     265 QKIkklWKGKFNFIPVLSEEPkeSSWKGERGLVTSKIkeyi--tnktEAYLCGPPPMVDSATKELTLMGIpkHSIYADRF 342 Leptospira bifl...
YP_001234391 266 SLLtrsWISRFTFVPVLSAEPagSDWSGARGFVHEHLaalgvalaghQAYLCGPPVMIDAALPVLRAAGIaaADIHYDAF 345 Acidiphilium cr...
YP_001612480 272 ASIeerWRGRFVFIPVLSHEPegSSWTGRKGHVTDHLrevaaghadcAAYVCGPPGMIDAVLDVLRGEIPr-MHLHHDRF 350 Sorangium cellu...

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