1KRH


Conserved Protein Domain Family
BenDO_FAD_NAD

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cd06209: BenDO_FAD_NAD 
Click on image for an interactive view with Cn3D
Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal ferredoxin at the end fused to an FAD/NADP(P) domain. In dioxygenase FAD/NAD(P) binding domain, the reductase transfers 2 electrons from NAD(P)H to the oxygenase which insert into an aromatic substrate, an initial step in microbial aerobic degradation of aromatic rings. Flavin oxidoreductases use flavins as substrates, unlike flavoenzymes which have a flavin prosthetic group.
Statistics
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PSSM-Id: 99805
View PSSM: cd06209
Aligned: 25 rows
Threshold Bit Score: 304.902
Threshold Setting Gi: 33599717
Created: 4-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Structure:1KRH: Acinetobacter benzoate dioxygenase reductase binds FAD, contacts determined at 4A
    View structure with Cn3D
  • Comment:FAD contacts lie primarily in N-terminal region

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #           ####             ### #  ####    
1KRH_A       108 HFEGTLARVENLSdsTITFDIQLddgqpdIHFLAGQYVNVTLPGTtetRSYSFSSQPgn-rLTGFVVRNVPQGKMSEYLS 186 Acinetobacter sp.
YP_298601    107 KFEGAIASVDKLSdsTIGFSIDLdda-gaLDFLPGQYVNVEIPGSgltRSYSFSSAPga-gHTGFVVRNVPDGRMSSYLT 184 Ralstonia eutro...
BAG30837     105 EVEALVTRVEVLSdsTATLHLDAssrkgqLDFLPGQYAHVQVPGTdewRSYSFACEPnesnRLQLLIRLLPDGVMSNYLR 184 carbazole-degra...
NP_251204    106 AHSGLVRELRLLSedTALLRLDAgaagrqLDFLPGQYARLQVPGSdcrRAYSFANRPnpqnHLQFLIRLLPGGAMSDYLR 185 Pseudomonas aer...
Q51603       105 TMTGQMTEIDRGSssTLQFTLAIdps-skVDFLPGQYAQLRIPGTtesRAYSYSSMPgs-sHVTFLVRDVPNGKMSGYLR 182 Burkholderia ce...
YP_001415959 103 PFTLRIESLEQLGasVIRLKGQTlgl-kpLVFLSGQYINLKVPGTealRSYSMANPPsgerSLELLIRLLDDGAMSTYLR 181 Xanthobacter au...
NP_216453    104 TGDGVVTAVELVSpsTAILRVDTsgmagaLRYRAGQFAQLQVPGTnvwRNYSYAHPAdgrgECEFIIRLLPDGVMSNYLR 183 Mycobacterium t...
YP_692390    107 RFRAWVEDIHRLNdsVVELTLEVdeaerdAQFLPGMYYLLRVPNTdiwRPYSMSSTVeqlpSMRFLIRLLDDGAMSTYLE 186 Alcanivorax bor...
YP_284578    116 KVRAFIDDVEKLAhnVVRLTLELaeg-ewLDFRPGQFVQVKVPGLsvmRSYSPASTSadlpKIVLLIRLLPDGAMSNYLR 194 Dechloromonas a...
YP_743289    118 QSEAEITELEWLSsnVVRLALTLped-qtFEFWPGQYARLRIPGTedwRSYSMSSAPgeapRVEFLIRILESGAMSDYLR 196 Alkalilimnicola...
Feature 1                                          #  #                                          
1KRH_A       187 vqAKAGDKMSFTGPFGSFYLRDVk-RPVLMLAGGTGIAPFLSMLQVLEQkg--seHPVRLVFGVTQDcDLVALEQLDALq 263 Acinetobacter sp.
YP_298601    185 ndAQPGQRIAFSGPYGSFYLRPVq-RPVLLLAGGTGIAPFLSMLDVLASng--npHPVRMVYGVTNDiDLVELPRIDGAa 261 Ralstonia eutro...
BAG30837     185 drAQPGDRIRLKAPLGAFYLQQVk-RPLIFVAGGTGLAAFLGMLDQMVSnparqtQSVRLFYGVTRPqDLCELERLKGYe 263 carbazole-degra...
NP_251204    186 qgCRVGDEIRFEAPLGTFYLRQVe-RPLLLVAGGTGLSAFLGMLDELAErg--ceWPVHLYYGVRRAaDLCELQRIAGYa 262 Pseudomonas aer...
Q51603       183 nqATITETFTFDGPYGAFYLREPv-RPILMLAGGTGLAPFLSMLQYMAGlqrndlPSVRLVYGVNRDdDLVGLDKLDELa 261 Burkholderia ce...
YP_001415959 182 erAAPGDQIACEGPRGTFYLRDGt-RPLLMVAGGTGLAPMLAMLRQIASap--tsRAMTLCFGVNTPeDLFCLDDLAELa 258 Xanthobacter au...
NP_216453    184 drAQPGDHIALRCSKGSFYLRPIv-RPVILVAGGTGLSAILAMAQSLDAdv---aHPVYLLYGVERTeDLCKLDELTELr 259 Mycobacterium t...
YP_692390    187 keCAIDAELEIDGPHGAFKMQQPpqGPVVLIAGGTGLAPVLSILDTLAEmrw-raHPIHLHFGVNRLsELFYLDELAARl 265 Alcanivorax bor...
YP_284578    195 seAARDAVLELEGPFGSFFLREKvkAPHIMIAGGTGLAPVMSMIDSIQKtsg-kkPPILLSFGCATPdSLFCLDDIELRk 273 Dechloromonas a...
YP_743289    197 erAAVGDHIEVEGPHGAFYLREPe-GPLVMVAGGTGLAPMMAMLDTVRVqgs-raPKTLLSFGCATPdNLFHGDELELRc 274 Alkalilimnicola...
Feature 1                                                                              ####
1KRH_A       264 qKLPWFEYRTVVAHaes-qheRKGYVTGHIEYdwLNGGEVDVYLCGPVPMVEAVRSWLDTQGIQPANFLFEKFS 336 Acinetobacter sp.
YP_298601    262 qQLTGFEYRTCVASaes-ghdRKGYVTQHVEPewLNGGDVDIYLCGPVAMVDAVRNWLKESGVEPAGFYYEKFS 334 Ralstonia eutropha JM...
BAG30837     264 qSVPGFSFHSIVMNpdadwqgASGVVTDLFEEshFNGGEVDAYLCGPPPMVDAVKSWLDQRNMENSRIYFEKFS 337 carbazole-degrading b...
NP_251204    263 eRLPGFRFVPVLSEadadwdgRRGYLHEHFDAarLRDEAFDLYLCGPPPMVEAVRQWLRERSLEHLRLYLEKFT 336 Pseudomonas aeruginos...
Q51603       262 tQLSGFSYITTVVDkds-aqlRRGYVTQQITNddMNGGDVDIYVCGPPPMVEAVRSWLAAEKLNPVNFYFEKFA 334 Burkholderia cepacia
YP_001415959 259 sRLPGLEIRVAVARgdagpkwQAGYATDLLQP--GDVPGRDIYLCGPPPMTDAARAFLTAHGADPAAIFLERFV 330 Xanthobacter autotrop...
NP_216453    260 rRVGRLEVHVVVARpdpdwdgRTGLVTDLLDErmLASGDADVYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFV 333 Mycobacterium tubercu...
YP_692390    266 eWLPNLNLRVTLVEphtdwqgALGYATEGVPDa-ALGPDTEVFLCGPPPMVDAAVSSLEARGIPPAHIHFESFI 338 Alcanivorax borkumens...
YP_284578    274 hWLPSLTNRISVDReaa-gslLQGNPVDALRDddVKDPDTVAYICGPQPMIEAAYRRLEALGVRHENIFAEQFT 346 Dechloromonas aromati...
YP_743289    275 fWMSKLEVRTSVDQapegyagRIGTPVDALQAadVAAPGTTAYLCGPPPMIEAARARLIELGLPADRIFAEQFT 348 Alkalilimnicola ehrli...

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