Conserved Protein Domain Family
CyPoR_like

?
cd06207: CyPoR_like 
NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via FAD and FMN. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
?
PSSM-Id: 99803
View PSSM: cd06207
Aligned: 20 rows
Threshold Bit Score: 423.993
Threshold Setting Gi: 159471980
Created: 15-May-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:determined by homology to rat NO synthase reductase

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       #                                 
XP_001876760  676 TCTVNKRLTPley-drnVFHLEFDtag----------tgLKYSIGEALGIHGWNeeAQVLDFCAWYGVDhnrlitipv-- 742  Laccaria bico...
XP_976589     264 NVKSIKELRQnnn-dgsTLHMEIDlkn----------tnLKYKTAMNIEIFAENdpALVEKVGAHLNLDlnqrvelvvde 332  Tetrahymena t...
XP_001424085  268 QVVSISQLRQnqk-dgsTLQIIFDtgr----------egIEYKTAMNLGVYPENddQQILEIANYLGENldtvyslellq 336  Paramecium te...
ABJ09678      210 VVKQNVRLTAkdh-fqaIHHIAFSrvvtflegaversdpLSFEVGDALGIYCANsdAVIDSFLAQTQLSgdvvicvtpni 288  Trypanosoma c...
XP_001433545  207 KIIEIKELRKapspgnsTLYLSLEsq------------nIPYKAAQNIGIYPENseEYIQEICTIFNLDpkyifqiet-- 272  Paramecium te...
XP_001686370  216 EVVANRRLTSaac-eqvVHHLELRagpd-------stdaAAYEVGDALGIYCPNreELVERLLRRLQRDgaemvvvtpds 287  Leishmania ma...
XP_001007585  217 RVVENELLTPady-dreTRKIEFEfds---------ndqTSYNPGDILVIHPENshQLCKDLADHLNLSlsqivritkne 286  Tetrahymena t...
XP_001694134  208 RLVCNQRITApdh-fqdTRHVELDleg----------sgLSYEPGDVISVLPMPseAVADAFLTRLGLDgdqwareqgqq 276  Chlamydomonas...
XP_001460994  175 EFTNKKRLSAeqh-dkeTYQYNFKc-------------nKLYECGDILCVKPRNqdKLVSQFLAILNLDgnkwvkleeqk 240  Paramecium te...
XP_001007559  279 PVKEIRELRQkpd-essCLHIDFDiss----------tgFKYDTAGNLGVYPENdyKSIQDFATLQGYSlddvfvlepsq 347  Tetrahymena t...
Feature 1                                                                                         
XP_001876760  743 -------vgeeqkmhtRTVLQALQQQVDLFGrp--------------pKSFYSDLAEYATSSvdr--------------h 787  Laccaria bico...
XP_976589     333 e---fiekfkypfpspISIRSILTKFCDFQGql--------------mKKTLKDLAKLTTNEehk--------------s 381  Tetrahymena t...
XP_001424085  337 q----nnrakvpfpspLSVRKILKHFVDFNGqlmkntltklskissndEKLKNQLIQLTTEEgk---------------a 397  Paramecium te...
ABJ09678      289 segliqqrsqpffgrpMRLRFFLMHYFDLEAva--------------sRSFFSMLARFAGDDeevrerlfe-lassdhld 353  Trypanosoma c...
XP_001433545  273 -------kgnhpfptpISVHNYLKKYCDFLGpi--------------tKKQLYTLSQLVDDQqak--------------e 317  Paramecium te...
XP_001686370  288 shglvrqptrpffgrpLSLHSLLRHYFDLDAvv--------------sQEFLWMLAHGVTGEdevav---------dvre 344  Leishmania ma...
XP_001007585  287 k---slqqfknpfpeyITIEQLFKQWLSISTpp--------------tRYLFKLMSYFTNDElhn--------------e 335  Tetrahymena t...
XP_001694134  277 gaggagaagvgpcaftARVRSLVTGCLDIGGgs--------------pRRYLFQVLLQSATAehererlsy-fatadgrd 341  Chlamydomonas...
XP_001460994  241 -----qnqkskkipkiISIQQLFSEFLDITSpp--------------nRYFIKLMSQYAERDihkqkltemcaqtpegle 301  Paramecium te...
XP_001007559  348 ------ertklplpspMKVSTFLSKFCDLFGpv--------------nKTILQGLADLSGNQqfi--------------a 393  Tetrahymena t...
Feature 1                                                                ####               # #   
XP_001876760  788 aLLFIGSPDGsstfkkmsekdtltfadVLKKYPSArpgVEKLCELI----GDIKPRHYSIASAQsvv-gdrVDLLVVTVD 862  Laccaria bico...
XP_976589     382 kLEKLASAAGkkefdseiyqkkkclfdLLKEYQIVp-tLEQFVDLC----PRLSPRLFTISSSDvkn-peiVTVTDSLVA 455  Tetrahymena t...
XP_001424085  398 gFQNLVDNMKtti------------yqLIKENNIKl-nLAQFIELC----PRISPRLFTIASSNlkn-pqhVEIADSLLI 459  Paramecium te...
ABJ09678      354 dFMSYSHREKrnv------------veVLSDFRLVrppLSFLLSFM----PPMRPRIFSISSSPtfd-vseIHLTVAQLS 416  Trypanosoma c...
XP_001433545  318 eLKFVSSHKGreeydtnylqtrqcffnLVKKYNIRnisLQQLIELC----PLISPRYFTIASSPlkn-pnkIEIIASELL 392  Paramecium te...
XP_001686370  345 rLYELADPSNvndylqy----ahrekrNLCEVLHDfkdLHPSLELVlsfaTPMLPRYFSIASAPamdgagrFDLCVGLLD 420  Leishmania ma...
XP_001007585  336 kLIEISSKEGkeeyynyvvkekrnvfeILFDFGTVqipLEYLIEGL----SLQKPREYSISSSQlsn-knrVSITIGLVK 410  Tetrahymena t...
XP_001694134  342 dLYRYNQREGrtl------------leVLQDFRSCappLARLLEAA----PHLRPRQFSAASSPrlrgpaaAQLLVALVS 405  Chlamydomonas...
XP_001460994  302 eYYSYVYREKrnv------------yeVLYDFQPCfipLEFLIDSL----KLIRERQYSISSAYdg---eqISLTVALVS 362  Paramecium te...
XP_001007559  394 dCEKWVSDSQgfeeni------reknhSIFSLSKQykiRIPLLSLIki-sNRIFPRFYTISSSNnsn-pkdLHMCISISK 465  Tetrahymena t...
Feature 1                   ####                                                                  
XP_001876760  863 WkdsngkiryGQCTRYLAGLr-------vGQKVTVSIKPSVMKLPPnp-kQPIIMAGLGTGAAPFRAFLQHLawla---- 930  Laccaria bico...
XP_976589     456 DkledgsikhGICSKYLINFqnklkngmtGNRIRVGFKASSFILPQds-kTPIIMIGPGTGIAPFIAFCQEKealle--- 531  Tetrahymena t...
XP_001424085  460 DtlpngteklGLCSQYFINVqkkl-legeCVRVRVDFRESSFKLPDdp-nKSIIMVGPGTGIAPFIGFLQEReifl---- 533  Paramecium te...
ABJ09678      417 WqtplkrsrkGVYSSYLAAAv-------pGDFFTCFLWRGSLPLPSk--pVPLICVGTGTGIAPLRSLIRECaaa----- 482  Trypanosoma c...
XP_001433545  393 Inke----rlGLCSQFLRNVk-------vGQEIKCFLQDSAFLMPQnp-qAPILLLGIGAGLAPMRAFIQEKdefieqnr 460  Paramecium te...
XP_001686370  421 WhtplkrhrtGLCSSYLVGAa-------pGTRLTCFVWQGSLALPAt--pTPLLCIATGTGVAPIRSVLRQVagls---- 487  Leishmania ma...
XP_001007585  411 YqtpfkrsivGVCSQYLKQIel------kQQKVIAWIKKGTMEMPFndptIPVILVGPGTGIAPFMSLVEQRnilierqq 484  Tetrahymena t...
XP_001694134  406 YvtpykrsrqGLCSAYLAGLepke--ggeEVRVAVWTERGSLRMPRsl-qTPLILVGPGTGVAPFRSFLEERcalarqah 482  Chlamydomonas...
XP_001460994  363 YttgknrpikGFCSNYLDNLv-------hGQQIEGKIIKGTIAFPKql-eIPIIMVGPGTGVAPFIGFIEQRvkq----- 429  Paramecium te...
XP_001007559  466 Vkdps-gtrnGQASSFFTALksn----ysGKRVRIFHQESTFKLPQdk-eKPIIMVGPGAGLAPFRAFLQEKqffee--- 536  Tetrahymena t...
Feature 1                                                                                         
XP_001876760  931 -rngEEIGPVYYYFGSRHqaSEYLYGEEIEAfvl---dgvISRAGLAFSRDSak-------kVYIQHKMLed----sEAL 995  Laccaria bico...
XP_976589     532 kginICPGEFTLYFGCRHqnGDYIFREELEQyvk---sgiINKLYTAFSRDQgs-------kVYVQDLMIkn----eEEI 597  Tetrahymena t...
XP_001424085  534 qsqpQRQNEYILYFGCKHqdGDFIYKDQLREfer---sktIDRFYTAFSRDQeq-------kCYVQDLLKrn----sEEL 599  Paramecium te...
ABJ09678      483 -gsiWSDVPLLLVFGCRHegKDYIYSNEWSElskd--rlkKLTVLPAFSRDGnk-------kFYVQHQLGrh----aRRV 548  Trypanosoma c...
XP_001433545  461 ldqsPFKGPMTLFFGCKTm-SDYLFKEELEEyek---ngtLNQLKVAFSREGq--------qIRITNFLDv------EFL 522  Paramecium te...
XP_001686370  488 -tqgWADVPVVLVFGCRRetEDYLYREEWATlkem-galpTLRVIPAFSRDTdk-------kVYVQHKLGqh----aRLT 554  Leishmania ma...
XP_001007585  485 ltqeQYSNKTFILFGCRYkqKEFYYQKFLEElhe----lnRINLFTAFSRDFds-------kVYVQHLLTkhyevfgDLI 553  Tetrahymena t...
XP_001694134  483 aagqPPPAPCFLFFGCRSpaADFYYQAQWEEyrrlgvldrEHGLITAFSRHTpeqqaqqgqaVYVTQRIReh----gALV 558  Chlamydomonas...
XP_001460994  430 --gaKNKEKTILFFGSCYenKEFYYKEFLQEs--------AITLFTAFSRDQqk-------kIYVQHRILen----rDLI 488  Paramecium te...
XP_001007559  537 skqnTQFGETVLYFGCRGkkVDYIYKSDLEDfek---skvCNKLRLAFSRDGpn-------kVYVQDLMQed----lELI 602  Tetrahymena t...
Feature 1                                                                                         
XP_001876760  996 AQMLHDDe-----gVFYLCGPTw-------------------PVPDVYEALvnalvkyk--gsdsvkaGEYLESLKekeR 1049 Laccaria bico...
XP_976589     598 YNTFFERn-----gLIYICGQNifyqlnlftnyyiliksataMGESVVNALrkivqkfk--nideqeaHKFVENLEkekR 670  Tetrahymena t...
XP_001424085  600 YNQILNDk-----vVIYICGSTs-------------------MGNSVQNLIkeilstng--nwteheaEEKIQSMEkqkL 653  Paramecium te...
ABJ09678      549 AKLLDEGa------YIYVCGNSt------------------pMPKDVAMTFdeigtqcc-cdgdelrgQEYMKQLRkqgR 603  Trypanosoma c...
XP_001433545  523 NQLLESGg------VIYVCGSTq-------------------MGRDVQIAIenmfkqvr--kvmpylaYRKVNELEeqkI 575  Paramecium te...
XP_001686370  555 SSFLQPEgagvppgVVYVCGNAk------------------qMPKDVQHTLeqiveatvagvqdeagaAAHIRALGrvgR 616  Leishmania ma...
XP_001007585  554 ANNFEKI-------KIFVCGTAk------------------yMPKQVEEGFvelltkyl--egdsekaKAIIQNLIkkrQ 606  Tetrahymena t...
XP_001694134  559 WRLLNGLp------PAAAAAPAta-----------------aMPAGVAAAFadvavahg--gldkeaaAAWVRQLElrgR 613  Chlamydomonas...
XP_001460994  489 NKIVRENaq---nvMIIVTGTSk------------------kMPTQVEQVFkec------------lgEQMLQELKrrkQ 535  Paramecium te...
XP_001007559  603 ADLFLNKq-----gTIYVCGSKa-------------------VGESVKEFIinmyqeke--gmvpylaYSKIAELEsekR 656  Tetrahymena t...
Feature 1               
XP_001876760 1050 YVLEVY 1055 Laccaria bicolor S238N-H82
XP_976589     671 IIKELW 676  Tetrahymena thermophila SB210
XP_001424085  654 LIKELW 659  Paramecium tetraurelia strain d4-2
ABJ09678      604 YMVDSW 609  Trypanosoma cruzi
XP_001433545  576 FVKELW 581  Paramecium tetraurelia strain d4-2
XP_001686370  617 YQVDSW 622  Leishmania major strain Friedlin
XP_001007585  607 YVVEAW 612  Tetrahymena thermophila SB210
XP_001694134  614 YFVEAW 619  Chlamydomonas reinhardtii
XP_001460994  536 YLVECW 541  Paramecium tetraurelia strain d4-2
XP_001007559  657 IIMEVW 662  Tetrahymena thermophila SB210

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap