1TLL


Conserved Protein Domain Family
Nitric_oxide_synthase

?
cd06202: Nitric_oxide_synthase 
Click on image for an interactive view with Cn3D
The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an inserted connecting sub-domain within the FAD binding portion of FNR. NOS differs from CYPOR in a requirement for the cofactor tetrahydrobiopterin and unlike most CYPOR is dimeric. Nitric oxide synthase produces nitric oxide in the conversion of L-arginine to L-citruline. NOS has been implicated in a variety of processes including cytotoxicity, anti-inflamation, neurotransmission, and vascular smooth muscle relaxation.
Statistics
?
PSSM-Id: 99799
View PSSM: cd06202
Aligned: 12 rows
Threshold Bit Score: 666.727
Threshold Setting Gi: 115692139
Created: 14-May-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #                                           
1TLL_A        255 RLLSRQNLQSpkssrsTIFVRLHtngnQELQYQPGDHLGVFPGNHeDLVNALIERLedappanhVVKVEMLEERNtalg- 333  Norway rat
Q27571        931 KPHNLTRLSEga--ktTMLLEICa---PGLEYEPGDHVGIFPANRtELVDGLLNRLvgvdnpdeVLQLQLLKEKQtsng- 1004 fruit fly
NP_990292     733 KLKFRQNLQSlkssrvTILVKLScetnQEVHYLPGEHIGISPGNQpELVHGLIARVkdappadqTIRLETCTEGGy---- 808  chicken
AAK61379      690 KVISVKELQSrnsrrsTILVRFDveknKELNFEPGDHVAIFPANRaNTVQDLIDMMhekptpdqPIRIEVARENSgkpgg 769  Discosoma str...
AAT46681      729 RNLHGENASSgggsrgTQQVVLStsgtNELHYQPGDHVAILPANRkELVDAVLARLqqcpdpdqPIQVLLLKEIHslng- 807  blackback lan...
NP_571735     998 KVVQRQNLQSarsnrlTIFVRLDannhESLKYLPGDHLGVFPGNNeDLVTTLIEKLedappvnqIVKVEFLEERNtalg- 1076 zebrafish
XP_001631503  683 KVKSVKKLQSadssrsTILLKLDtspaAEFHYNPGDHLSVFPCNRrELVQSLIDRLceapdpdqPIKLEVCQETSgkrpf 762  starlet sea a...
AAS93627      688 TVIERHNLQSpiserqTILLKLDtrgsSSFTYAPGDHVGIYPANRpDQVETVLSRLhnappadqVVKLEVLQERSpplg- 766  common cuttle...
NP_001079155  986 RLLSRQNLQSpkssrsTIFLKLHsnghKELCYKPGDHLGVFPGNHeDLVNALIERLddappvnqMVRVEMLEERNtalg- 1064 African clawe...
BAF73722     1174 VLTERTHLQSeesdrqTILVKLNtqgaDELVYVPGDHVGVFPANApDLVDAILTRLhnapppdqIIKTEFLHEVStplg- 1252 Lehmannia val...
AAQ02989      896 TVISRTQLQApesgrqTCLVELEthgaQELKYVPGDHVAIFPANEdRLVQAILDRLekgtnpdaVILIEALQEKKsasg- 974  Florida lancelet
XP_791956     845 KSAKQSPLSSr----sTILVRLNtnkeRGMAYQPGDHVAFFPSNEnALVARVLKRLdyqkspdaIFKLEKLEPRE----- 915  purple urchin
Feature 1                                                                                         
1TLL_A        334 --visnWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATne---keKQRLLVLSKGLqEYEEWKWGKNPTMVEV 408  Norway rat
Q27571       1005 --ifkcWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEdt---adKERLELLVNDSsAYEDWRHWRLPHLLDV 1079 fruit fly
NP_990292     809 ------WASEKKIPACTLSQALTYLLDITTPPTQQLLKKLSQLVTae---gdKQRLEVLCHSTeEYNKWKFYNRPNILEV 879  chicken
AAK61379      770 --grtwESFKRLPVACTLREALTRYLDISSVPTPQMMLYLSKLATsp---leKLQLEALGKGGsRYGDWVLKKECNILET 844  Discosoma str...
AAT46681      808 --itqtWEPHERLPSASVRELLTRYLDITTPPAPNFLHMLAEYAHdn---dqRTRLDQLATDPhEYEEWKHLRYPHLREV 882  blackback lan...
NP_571735    1077 --visnWTDESRIPPCTIYQAFKYFLDITTPPSPVLLQQFAPLATne---kqRKRLEVLSKGLqEYEEWKWYNNPTMVEV 1151 zebrafish
XP_001631503  763 gktkkwTPVDRLPTPTTVREAFSRFIDIAGTPTPQILKSLASLATnp---kdREALETLGKGDnHYDDWKYEKQSNIVEV 839  starlet sea a...
AAS93627      767 --paksWTGFERFPICTLRTAFTRYLDISITPSKNLLQLFAVLATsd---sdGERLDTLAKDSqAYENYKQYHSPNLAEM 841  common cuttle...
NP_001079155 1065 --visnWTEEERIPPCTIFQAFKYFLDITTPPTPLLMQQIALLATde---keKKRLEILSKGLqEYEQWKWYKNPTIVEV 1139 African clawe...
BAF73722     1253 --tnktWTLFEKMPVCSMRMAFTHILDVTTPPPQSLLQLLATQTTre---mdKTRLELLATDAsEYENWKYDFRSNILEL 1327 Lehmannia val...
AAQ02989      975 --lvktWTSHNRLPPCSLRTALSRYLDVTTPPSPQLLLYLAMHTCtrtssreRAELEALGKGGaRYEDWKFEAAPTLPEV 1052 Florida lancelet
XP_791956     916 ------TQLVSRLPTCSLRTALERYLDLTTPPTPDFLRLLATRATdp---rdKEKLSILGAGCdEYEEWKWENWPNMAEV 986  purple urchin
Feature 1                                ####              # #               ####                 
1TLL_A        409 LEEFPSIqMPATLLLTQLSLLQPRYYSISSSPDMYPdeVHLTVAIVSYHtrDGEGPVHHGVCSSWLNRIQaDDVVPCFVR 488  Norway rat
Q27571       1080 LEEFPSCrPPAPLLLAQLTPLQPRFYSISSSPRRVSdeIHLTVAIVKYRceDGQGDERYGVCSNYLSGLRaDDELFMFVR 1159 fruit fly
NP_990292     880 LEEFPSAeVSTAFLLTQLPLLKPRYYSVSSSCDMTPreIHLTVAVVNYRtrDGQGPLHHGVCSTWLNKIAlNETVPCFVR 959  chicken
AAK61379      845 LQAFPSVqVTADLLLTQLPLLQPRFYSISSSPDVHRneIHATVAVVEYKkrGGQGPVHHGVCSTWLQGLTpGDTAACYIR 924  Discosoma str...
AAT46681      883 LEEFSSVnLDAGLLLTHLPLLGPRFYSISSSPEAHPgqVHVTVAIVQYHteGGKGPLHYGVCSNFLKEVSpGDHVELFVR 962  blackback lan...
NP_571735    1152 LEEFPSLqIPSTLLLTQLPLLQPRYYSISSSPDLYPgeIHLTVAVVSYRprDGEGPIHHGVCSSWLNSLDeGDTVPCFVR 1231 zebrafish
XP_001631503  840 LEEFPSVnVEAEMLLTQLPLLQPRFYSISSSQDFSPneVHLTVAVVQYNkrEGKGPVHYGVCSTWFNGLKpGDIVPCFVR 919  starlet sea a...
AAS93627      842 LKDFPSLkIPPTLLLTQLPLLQQRFYSVSSSPKFHPgeVHLTIAIAKYI--KPNGVIHHGICSTWLQTCPvGEQVPCVIR 919  common cuttle...
NP_001079155 1140 LEEFPSIqMPSSLLLTQLPLLQPRYYSISSSPEMYPeeVHLTVAVVSYRtrDGDGPIHHGVCSSWLNRIHpDEVVPCFVR 1219 African clawe...
BAF73722     1328 LDQFSSLrVAPSLLLTQLPLLQQRYYSISSSPQMFPgeIHGTVAVVRFRtqDGAGPVHEGVCSGWLNGCTpGTTVPCLVR 1407 Lehmannia val...
AAQ02989     1053 LQDYPSLqVPPALLLSQLPVLQQRYYSISSSPHMYPgqIHATVAVVKYRtrGGKGPEHSGVCSNWLNTINiNESVPCFIR 1132 Florida lancelet
XP_791956     987 LEGYPSLkVPASLLLTQLPLLRPRYFSISSSPKQYPneIHATVAVVSYHpnGGRGPVHYGACSSWLYRAWkDEVIPAFVS 1066 purple urchin
Feature 1                                                                                         
1TLL_A        489 GAPSFHLPRnPQVPCILVGPGTGIAPFRSFWQQRqfdi---------------------------qhkgMNPCPMVLVFG 541  Norway rat
Q27571       1160 SALGFHLPSdRSRPIILIGPGTGIAPFRSFWQEFqvlrd--------------------------ldptAKLPKMWLFFG 1213 fruit fly
NP_990292     960 SADGFRLPKePAKPCILIGPGTGIAPFRSFWQQRlydl---------------------------ekkgIKGGDMILLFG 1012 chicken
AAK61379      925 HAQSFHLPSdATVPVILVGNGTGIAPFRGFWQQRmfdmnnkclp---------------dpqpgsrqrcGRWGEMALFFG 989  Discosoma str...
AAT46681      963 SASSFRLPCdPSVPVIMVGPGTGVAPFRGFWHHRhyslr-------------------------hkkptEKFSQMTLFFG 1017 blackback lan...
NP_571735    1232 GAPSFRMPKdSQVPCILIGPGTGIAPFRAFWQQRqydv---------------------------enkgIKACPMILVFG 1284 zebrafish
XP_001631503  920 KAHSFHLPDdGSLPIIMVGPGTGIAPFRSFWQQRqydivkkpsp---------------vpkprdaapgSGWGDMVLYFG 984  starlet sea a...
AAS93627      920 AAPNFHMPEdGTRPIIMVGPGSGIAPFRSFWQQRkidkemlavpr--------------rkfhdpygekKGWGSMTIYFG 985  common cuttle...
NP_001079155 1220 GAPSFQMPEdPQVPCILIGPGTGIAPFRSFWQQRlydm---------------------------qhrgLKPCPMILVFG 1272 African clawe...
BAF73722     1408 AAPTFHLPDnPSLPVIMVGPGTGIAPFRSFWQQRsidlemmn--------------------vpshddrKVFGEMSLYFG 1467 Lehmannia val...
AAQ02989     1133 TAKNFHLPEdPSLPVLMVGPGTGIAPLRSFWQQRqvdikd------------------------gttsrHPPGDMTLGVR 1188 Florida lancelet
XP_791956    1067 SAPYFHLPAdTSVPVIMVGPGSGVAPFRSFWQDRqtdlrqlasfnselassrktketdtrgrrgegdgsDTFGDMTLVYG 1146 purple urchin
Feature 1                                                                                         
1TLL_A        542 CRQs-kIDHIYREETLQaknkgvFRELYTAYSREPdrpkKYVQDVLQeqlaESVYRALKEQgGHIYVCGDVTMAADVLKA 620  Norway rat
Q27571       1214 CRNr--DVDLYAEEKAElqkdqiLDRVFLALSREQaipkTYVQDLIEqe-fDSLYQLIVQErGHIYVCGDVTMAEHVYQT 1290 fruit fly
NP_990292    1013 CRHp-dMDHIYKEEVEEmkrkgvLKEVFTAYSRQPgqpkVYVQDILQneleTKVCNILHKEeGHLYVCGDVRMARDVAQT 1091 chicken
AAK61379      990 CRNs-qHDDVFRHEIEKaiysktISTVAKAFSREQgkpkRYVQDLLKed-aGNVCDLIVDSnAHVYVCGGAAMANDVSKT 1067 Discosoma str...
AAT46681     1018 CRTr--AMDLYAEEKETmktcgvLTHTHLALSREPtlpkTYVQDLLVev-gEQVYQQVVLEkGHFYVCGDCTMAECVYQK 1094 blackback lan...
NP_571735    1285 CRQs-qIDHIYKEQTIQaknkevFKELYTAYSREPgrpkKYVQDVLReqlsETVYKCLREEgGHIYVCGDVTMAGDVLKT 1363 zebrafish
XP_001631503  985 CRCs-tLDDIYQEETKTahqdgaLAAVRTALSREPghvkQYVQDLLKed-aDAIIDKLVGQgAHLYTCGDVSMAADVCRT 1062 starlet sea a...
AAS93627      986 CRDr-nIDNIYENELKQyqeedvLQDVYFGFSREPgkkkTYVQHLLKkn-sKSVCDAIVREgGHFYVCGDVQMASDVSDT 1063 common cuttle...
NP_001079155 1273 CREs-kIDHIYKEETMHaknkgvFKELFTAYSREPnkpkKYVQDVLKeqlsEVTYKALKDQgGHIYICGDVNMAGDVLKS 1351 African clawe...
BAF73722     1468 CRTk-lQDNIYGKELEEmknqevLASYYVALSRELdmpkAYVQDILLsk-aEAVHEAIVKRgGHFYVCGDVSMAHDVTQT 1545 Lehmannia val...
AAQ02989     1189 LYTvqtGPHLQGETTQArrd-gaLTDIHTALSREPgttkTYVQDIIRqqipRKVLDLVLRDgGHVYVCGDVTMATDVCET 1267 Florida lancelet
XP_791956    1147 CRNa--KEDLYKGETSVakdegaLTAVLTGYSREPgkprKYVQDILKdh-pWLVYNVLYRRqGHIYVSGDVNMVREVSNT 1223 purple urchin
Feature 1                                               
1TLL_A        621 IQRIMtqqgklseEDAGVFISRLRddNRYHEDIFGVTL 658  Norway rat
Q27571       1291 IRKCIagkeqkseAEVETFLLTLRdeSRYHEDIFGITL 1328 fruit fly
NP_990292    1092 LKRMLvkklnhteQQAEEYFFQLKsqKRYHEDIFGAVF 1129 chicken
AAK61379     1068 IQNMLadrlslsaDDALEYMRGLKssNRYHEDVFGVAQ 1105 Discosoma striata
AAT46681     1095 LRSIVqehgrlsdQEVENFMLQMRdeNRYHEDIFGITL 1132 blackback land crab
NP_571735    1364 VQQIFklhgnmslEDAGFYISKLRdeNRYHEDIFGVTL 1401 zebrafish
XP_001631503 1063 IQKLLeeyaamtqQEAQEFIDNLKssGRYHEDIFGVTL 1100 starlet sea anemone
AAS93627     1064 VEMILkedapmssEEAKNYVLKLRdaNRFHEDIFGVTV 1101 common cuttlefish
NP_001079155 1352 LQHVVkesgnltiEEAGAFISKLRddNRYHEDIFGVTL 1389 African clawed frog
BAF73722     1546 LEAILqeqgqmsaEDACNFVTKLRdtNRFHEDIFGVNF 1583 Lehmannia valentiana
AAQ02989     1268 IQRILvehggmsrARAEDFINTMKdnNRYHEDIFGVTL 1305 Florida lancelet
XP_791956    1224 IEGIIaqfgrvgaAEAKDFVRRIKdeDHYHEEMYGLTL 1261 purple urchin

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap