1DDG


Conserved Protein Domain Family
SiR

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cd06199: SiR 
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Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ gene) are of the cytochrome p450 (CyPor) family having FAD and FMN as prosthetic groups and utilizing NADPH. Cypor (including cyt -450 reductase, nitric oxide synthase, and methionine synthase reductase) are ferredoxin reductase (FNR)-like proteins with an additional N-terminal FMN domain and a connecting sub-domain inserted within the flavin binding portion of the FNR-like domain. The connecting domain orients the N-terminal FMN domain with the C-terminal FNR domain.
Statistics
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PSSM-Id: 99796
View PSSM: cd06199
Aligned: 31 rows
Threshold Bit Score: 454.378
Threshold Setting Gi: 78486232
Created: 14-May-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #                                          
1DDG_A        15 SLSVNQKITGrns--ekdVRHIEIDLGDsGLRYQPGDALGVWYQNDPALVKELVELLWLkgdepv-----------tveg 81  Escherichia coli
NP_643637    258 KGPGFRVYAApg----krVRHLEFSLQGsGLSYEPGDALGIRHRNPPALVDAVLQTLRLdgdaav-----------tige 322 Xanthomonas axo...
YP_007225     15 TIRNRYQLSKsgs--qknTQHLVLDLRGsQLTYEAGDSIGVYPKHDPELINKTLIAARAsgeeyiq---------skqtg 83  Candidatus Prot...
YP_001639702 246 EVIDHVNLNSsrs--dkeTIHLALEFEDgAPAYEPGDSLEIFPENDPQLVDEILRATGLsg------------------- 304 Methylobacteriu...
ZP_01739299  233 EITELIQLNSsqs--ekaTIHLELGFDGaAPPYKPGDSLDIYPENDAAYVDDLLKAAGLaa------------------- 291 Marinobacter sp...
YP_001235911 235 EVAALHPITSsrs--eseTLHLELDLTGsGLSYEPGDTLGIAPTNAPSLADAILGATGLag------------------- 293 Acidiphilium cr...
YP_001838572 241 TIVTNLVLNDiga--tksTRHIEIKSSL-PVDYLPGDSAGFLAYNREDEVNRILGLLQTdretrv-----------tykg 306 Leptospira bifl...
XP_786318    258 TLLVKEELTNcnvpadkeTIHCELTIEGsKLMYEAGDAVGIYPRNRMEDVEWVIQASGLsrddmcsvps---sayqpqpv 334 purple urchin
XP_001703247 306 TVLALEGLCTlsgpddknTVRMELDLGDsGIGYLPGDALGLYPTNQPQAVEELLRVMGAsasesvpvpswhyeeegvapg 385 Chlamydomonas r...
XP_628906    253 KLLVKRVLTKgd----kvGIHLEFELGDsELKYVPGDALAILPDNAASEVSAIISLLKLspsfkvstpgwhyqegeqpnp 328 Dictyostelium d...
Feature 1                                                                                        
1DDG_A        82 ktLPLNEALQWHFELTvn-------taNIVENYAtltrsetll--------------------------------plvgd 122 Escherichia coli
NP_643637    323 qtLELHAWLATQRELTkl-------srPFLTAHAeragaqelqallap---------------------tqtaglaslla 374 Xanthomonas axo...
YP_007225     84 etISLRDFFSKQGNITdv-------sqKLLKELYnrqtnldkkhqlelll-----------------dennrvalkayla 139 Candidatus Prot...
YP_001639702 305 -dEGLRKALLAERDITtlsp---ttveRFAKATGhadaqkfve-------------------------------sgevka 349 Methylobacteriu...
ZP_01739299  292 -dAALRAELTKSRDVTtl-------slKTLESYAattghqevkalle------------------------sadarawia 339 Marinobacter sp...
YP_001235911 294 -dAAAREALIRERDITtl-------tpKLIADYAaltgeaklaala--------------------------adeaarta 339 Acidiphilium cr...
YP_001838572 307 etWMLYDLLRKKVSIRfl-------pdRVIQKYVslskke-------------------------------------ips 342 Leptospira bifl...
XP_786318    335 snVTLQESLHKYYDLKnv-------rvSLLQSMLrhsvgivkekleillen---------------gtsrsnqalmgyle 392 purple urchin
XP_001703247 386 gsMPLAQALTKCYDIRspkpellrllvAALDGTAndhaanghanghanghaingdaaavppqqrlrdalkdqaaieayle 465 Chlamydomonas r...
XP_628906    329 sqITLTHILTKCFDIHnckp----ellQLLKDNVknqqekekltnllaqg-----------------tgksntqlvefle 387 Dictyostelium d...
Feature 1                                              ####               # #            ####    
1DDG_A       123 kakLQHYAAttpivdmvrfspaqLDAEALINLLRPLTPRLYSIASSQae-vENEVHVTVGVVRYDvegraRAGGASSFLA 201 Escherichia coli
NP_643637    375 dhqVIDVLRrwp---------adWDHAGLLAALRPLTPRLYSVASSRkr-vGDEVHLTVDEVTYQahghaHLGAASGFLA 444 Xanthomonas axo...
YP_007225    140 lheVWDLLLfhv--------evhFTPQELADLLMPLLPRFYSISSSQky-vGEEVHLTIAHLEYEtnghkRRGVCTHYLC 210 Candidatus Prot...
YP_001639702 350 wieGRHLIDlier------fpttLTAEHLNTVTRPLPPRAYSIASSRke-vGDEVHLTIAAVRYEthgraRAGVASVHVA 422 Methylobacteriu...
ZP_01739299  340 grqLIDLLQsfp---------irLSADQLRQITRPLAPRAYSIASSRre-vGEEVHLLISAVRYQsfgraRKGVASGHVA 409 Marinobacter sp...
YP_001235911 340 fiaGRQPLDlfea------fphrLDAGQLAGLLRKLPPRYYSIASSQkl-vGDAAHLAIAKVAYEsagrtRLGVASGMVA 412 Acidiphilium cr...
YP_001838572 343 gklDLDVLLtlyp------sdtkLEIQSIVDILEPIVPRYYSIASSPsahgEEEVHLTVAEVEIEtftgiKTGFCSGFLS 416 Leptospira bifl...
XP_786318    393 taeVGDVLEdfp---------vnLPQTELLANLRPLQPRYYSISSSPvi-dPNKISVTAAIIRCSsrgrsRVGVATTFLQ 462 purple urchin
XP_001703247 466 prhVVDVLAdaa--------pakLTSSQVLSCLRQLQPRLYSISSSPle-aPARVQVTVAEVKYLslgkgRVGVCSTMLS 536 Chlamydomonas r...
XP_628906    388 nhhLIDILKmfs--------sarPPIDDLLAQLAKLLPRYYSIASSMse-nKLAVSLCVAVVKYDlhgseRVGIASTHMA 458 Dictyostelium d...
Feature 1                                                                                        
1DDG_A       202 DRve-eEGEVRVFIEHNDNFRLPanpeTPVIMIGPGTGIAPFRAFMQQRaa-------dEAPGKNWLFFGNPHFtEDFLY 273 Escherichia coli
NP_643637    445 ALg--eGDTAPVYIEPNERFRVPadadRDILMIGPGTGVAPFRGFVQERae-------tGAKGRNWLFFGAQHFnTDFLY 515 Xanthomonas axo...
YP_007225    211 ELvklhNPEVPVFIQPSHSFRLPedlhAPLVMVGPGTGVAPFRAFLQERvl------hhQTKGKHWLFFGERNRsSDFFY 284 Candidatus Prot...
YP_001639702 423 DRik-nGAKLRVRVKPNKHFRLPsdpsTDIIMVGPGTGVAPFRAFVQERra-------tEAPGRSWLFFGDRHFtHDFLY 494 Methylobacteriu...
ZP_01739299  410 DQlk-kGHRLRVKLRPNRHFALPpp-eRDIIMVGPGTGIAPFRAFVQERga-------tGASGRSWLFFGDRQFtHDFLY 480 Marinobacter sp...
YP_001235911 413 ERlr-eGDTLPIHIKANPHFRLPedssAPIVMIGAGTGIAPYRAFLQERea-------tGASGRTWLIFGHRRFtHDFLY 484 Acidiphilium cr...
YP_001838572 417 SLk--eGDTVPFFIQKNNSFRLPsp-dTDIIMIGPGTGIAPFRSFLFEReq-------sGGNGKNWLFFGERNFvSDFYY 486 Leptospira bifl...
XP_786318    463 DRlh-lHDLCPVFISPNPDFRLPqdgtRDIIMIGPGTGIAPFRAFMQERvl-------lGASGKNLLYFGCRHKgKDFIY 534 purple urchin
XP_001703247 537 ERlk-vGARVPVYVHKNPDFRLPadaaQPIIMVGPGTGLAPFRSFILERlleaqasngkKAPGEMVLYFGCRRSdQDYLY 615 Chlamydomonas r...
XP_628906    459 DRmn-vGDRVSIFINNNPDFRLPedptTPILMVGPGTGIAPFVSFIQERka-------lGHTGENHLYFGCRRSdEDFLY 530 Dictyostelium d...
Feature 1                                                                                        
1DDG_A       274 QVEWQRYvkeGVLTRIDLAWSRDQkEKVYVQDKLREqGAELWRWINDGAHIYVCGDAnRMAKDVEQALLEVIAEFGGmdt 353 Escherichia coli
NP_643637    516 QAEWQLAlrrGELHALDLAFSRDQaEKLYVQHRLRArGAEVYAWLQGGAHVYVCGAT-SMGKDVHAALLDIVATHGAqda 594 Xanthomonas axo...
YP_007225    285 EEDWRLFe-qHGHLRLDAVFSRDQeEKVYVQHKMFEhGEELFKWLEEGAYLFVCGDAeRMAKDVEITLLAIIQEFGKkdf 363 Candidatus Prot...
YP_001639702 495 QLEWQDAledGSLAKIDVAFSRDQpEKIYVQDRIDAhAAEVVEWLDGGAHFYVCGDAkNMAKDVRAAVVRAFESVKGlss 574 Methylobacteriu...
ZP_01739299  481 QLEWQDAlkdGSLTRMDVAFSRDTpEKLYVQHLIWAqRRDLVDWLDNGAYFYVCGDAkAMAKDVRAALVRAYADVKAqsl 560 Marinobacter sp...
YP_001235911 485 QLEIQDWlksGVLNEIDLAFSRDQpEKRYVQHVLWErRAALQAQLAEGATLYLCGDAkAMARDVDATLAHILGGDDAa-- 562 Acidiphilium cr...
YP_001838572 487 QTELLELmdtGVLHKLNTAFSRDTkEKVYVQDRMGEnAEELLKWIQNGAVIYLCGSKdPMSKDVDRKLIEILSERTFdtg 566 Leptospira bifl...
XP_786318    535 QKELEQMv-aEGHLKLRTAFSRDGeEKIYVQHLILQdGQMIWNMIQGGAHVYVCGDAkHMAADVHHALLSVIKTEGCmae 613 purple urchin
XP_001703247 616 GDVLEGWa-aEGKIKLFTAFSRQQaQKVYVQNRLTEsADLVWGLLEKGAHFYVCGDAsSMAGSVEKALLQLIGERLEagp 694 Chlamydomonas r...
XP_628906    531 SKELQQYh-nDGLIKLYTAFSRETsQKVYVQNRLLEnSQQICDLINAGGHIYICGDAkSMAPQVHETLSLIITKHMSide 609 Dictyostelium d...
Feature 1                             
1DDG_A       354 eAADEFLSELrvERRYQRDVY 374 Escherichia coli
NP_643637    595 eAAAAYLTQLqvEGRYARDVY 615 Xanthomonas axonopodis pv. citri str. 306
YP_007225    364 qEAREYVKRLrqQKKYLRDVY 384 Candidatus Protochlamydia amoebophila UWE25
YP_001639702 575 aDAEAHVASLerARRYQQDVY 595 Methylobacterium extorquens PA1
ZP_01739299  561 eAGEQAVNDLdgEHRYLQDTY 581 Marinobacter sp. ELB17
YP_001235911 563 -KGQAALDALiaAGRYKKDVY 582 Acidiphilium cryptum JF-5
YP_001838572 567 kEASDYLKELeeNGRYIKDVY 587 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'
XP_786318    614 eCALSYIKELeeTHRYQKDVW 634 purple urchin
XP_001703247 695 aGADAYLQKLsdTGRYQRDVW 715 Chlamydomonas reinhardtii
XP_628906    610 aDAQALLHKLekEKRYQKDVW 630 Dictyostelium discoideum AX4

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