Conserved Protein Domain Family
FNR_like_2

?
cd06197: FNR_like_2 
FAD/NAD(P) binding domain of ferredoxin reductase-like proteins. Ferredoxin reductase (FNR) was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and have a variety of physiological functions in a variety of organisms including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).
Statistics
?
PSSM-Id: 99794
View PSSM: cd06197
Aligned: 11 rows
Threshold Bit Score: 236.904
Threshold Setting Gi: 40738474
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #                                 
XP_001247525 360 IKKEVItp------------tIYRFRFQimnp----sivgKWDPGQYATLSFKDELDm---GYSHMQDD--DPTSINDDY 418 Coccidioides im...
EAT79582     356 TKKTLItps----------tgRFAFSVSpa---------iTYTSGQWIALDFKEELGi---GYEHMRDD--DPTSLNDDF 411 Phaeosphaeria n...
ZP_00955847  372 TLSESIk--------------TFNFELSqp--------vsVPLPGGFGVFDFSNLLDs---GYRHMNEA--NPQLVNEDY 424 Sulfitobacter s...
EAA57664     357 SEKARLqsarql----ssdlaVFRFKVVpsdtg---gvrlSIRPGQAVVLDFMDWLGp--pQYRHMADN--APGSINDDR 425 Aspergillus nid...
XP_001538101 349 IKKDIItpt----------igRFRFKISdps------kvgKWTPGQYATFSFAGELDm---GYSHMKDD--DPTSINDDY 407 Ajellomyces cap...
XP_359815    361 KQREVLspt----------itRYGFALQpptgfpkgqavgSWTVAQHATLDFSSELDa---GYSHMRDD--DPQSLNDDF 425 Magnaporthe gri...
EAK81232     404 IAFEQHtvd----------laSITFRLSpp---------vKYIAGQHVILDCGSLLDsdvkEYKHMSVKygGEQELNDGG 464 Ustilago maydis...
XP_389653    386 KDREVItss----------idRFTFELSsqq------pitNWHAGQYITLDFEPELSn---GYSHMADH--DPQSINDDF 444 Gibberella zeae...
EAU86339     380 IVSENIa--------------IFTFSPSvp---------iNHKPGQYIILDWRSFLGe--rQYRHMSPT--SPTSLNDDF 432 Coprinopsis cin...
XP_001885680 367 MHSATIa--------------TFTWESSee---------lVINPGQCVILDFTTLFGs--rEYQHMAPT--RPSSVNDDF 419 Laccaria bicolo...
XP_001906176 322 SLSEVHpvefspynpplrkltTEGPCSSvglq-----tsrHSYSWQHITLDFGGELDn---GWAHMNNS--DPQSLNDDY 391 Podospora anser...
Feature 1         ####                      # # #  # ##                                          
XP_001247525 419 IRTFTVSSHPgrnl------sqdeFEITVRKK--GRVTNHLFRANERs--------------GMEVSLRGF-DGSFRFes 475 Coccidioides im...
EAT79582     412 VRTFTISSAPntre------kqteFEITIRKV--GPVTEFLFQQNDRa--------------GFEVPVLGV-GGDFTIan 468 Phaeosphaeria n...
ZP_00955847  425 VRTWTISNTPvfdpgsnefaatnqVSVTVKKKpgGLMSNVLHANAYKli-----------eqRLPVEFKGS-GAGFTCfe 492 Sulfitobacter s...
EAA57664     426 VRTWTVSSSHegsq-------mswFELTMREIkgGAVTGALFDVLRKhpqepgr--lveieqSVAADIVGV-TGDFVLsd 495 Aspergillus nid...
XP_001538101 408 IRTFTVSSYPgrgi------sndeFEITVKKH--GSTTKHMFQSSERs--------------GVEVLLKGF-AGEFSFkd 464 Ajellomyces cap...
XP_359815    426 VRTFTVSSQPalsssnkgvanhgeMQITVRTN--GPVTRLLRNWNLRa--------------PLEIPVMGFgGGSLRIps 489 Magnaporthe gri...
EAK81232     465 IRTWTISSAPnhtgk-----aedtIVITMRRVgkGLITPKLFEVAKTtlte--------qpaSVVLPVLGV-GGEFVLsk 530 Ustilago maydis...
XP_389653    445 VRTFTVSSPPenh---------kdLQITTRRH--GPVTNFLRKHNSRv--------------LLEVPVIGF-GGEEGFri 498 Gibberella zeae...
EAU86339     433 IRTWTISSFAphdpdss-ptkandFQLTIRYQpgGAVTSPLFTMARKiqqtrpellddltslAIRPRIPGV-SGEFTLdl 510 Coprinopsis cin...
XP_001885680 420 IRTWTVSSAAkerk-------trmFSLTMREKpgGTVTGALFSLARSlreskr---ndmremAVAVKVAGV-MGEFCLp- 487 Laccaria bicolo...
XP_001906176 392 VRTFTISNSPpsnae-----qeikFEITARKH--GPVTGFLWGYHISpr-----------aaRLEIPVLGF-GGEENFrl 452 Podospora anser...
Feature 1                               #                                                        
XP_001247525 476 sg---------aanRILPCIAGGIGITPIIALLHTIDis----------rIHLYWSVAVqd--iGIVHDTFeqfpe---- 530 Coccidioides im...
EAT79582     469 ------------gdGVTPFVAGGVGITPLLGHLHSLDvsp--------erFTLFWTLSYhd--iQLAMDILmqfpq---- 522 Phaeosphaeria n...
ZP_00955847  493 pgtqn---appsvsSKMLWIAGGVGITPFMAMWDGILqlanah-pqtttdIVLLFSGRGd---dIKVLKHFvrqvgp--- 562 Sulfitobacter s...
EAA57664     496 ------------keINALWVAGGIGITPYLAMLEALGsheaegqgkstgdILFVLSTRE-----PDVMLELlqsplenvp 558 Aspergillus nid...
XP_001538101 465 ga--------egatTPLAYIAGGIGITPLIAQLPGIDis----------rLHLFWSVSArd--lGLVLDTFklfpe---- 520 Ajellomyces cap...
XP_359815    490 aa--------ddaaRPAVFVATGVGITPLLSQAGALLsapqe---aarprLSVLWSLRKed--lPFAADEFkrtpg---- 552 Magnaporthe gri...
EAK81232     531 aa---------gdgVKMLWIASGVGITPFLSFLRFLAssrh-----rkldVTLVLAVRRa---eALVMLDLv-------- 585 Ustilago maydis...
XP_389653    499 pl--------epegPKSIFIAAGVGITPVLAQAPAVLkhn--------vpFELLWTLRYed--lPLASDTFsripe---- 556 Gibberella zeae...
EAU86339     511 preneiqsagvegpRKLVWAAGGIGITPFLSMLRSIVhhsrrf-pavkwdILFLLSTREpeilvPLVIDACgaspddl-- 587 Coprinopsis cin...
XP_001885680 488 --------------TKMVWIAGGIGVTPFLSMLRAVLegrs-----ggwdITLILSMREpevilPLVFSILegapd---- 544 Laccaria bicolo...
XP_001906176 453 ig--------tgkeKQKVFVAGGVGITPFLGQVREIAatd--------heVELIWSLRAdd--lPFARDVLgrnegi--- 511 Podospora anser...
Feature 1                                                                                        
XP_001247525 531 --lpnstVLFLTGlqgveamlgeadkgmlesvak----------------snariehrrldvkdlvldgteEWYLCGSAs 592 Coccidioides im...
EAT79582     523 --lgratKLFFTGagneiiernyeelmiqqga---------------------hvymrrlrkedlagvdaeTWYLCAGPg 579 Phaeosphaeria n...
ZP_00955847  563 --vpanvKLGIVAfqsigddslvaksaredlrlafse----------dalqikerraqvediqsisaldkrEVYMCGPD- 629 Sulfitobacter s...
EAA57664     559 tgmkvkiDLFTRStvkadigefqtgkiqvsi-----------------------hegrigpqywktvptgkDVFICGPNd 615 Aspergillus nid...
XP_001538101 521 --lpkstTLFITSsqfannpiaeeatsleaindf----------------gaqhyrrrmeatdlgvvpgveEWYLCAGTs 582 Ajellomyces cap...
XP_359815    553 ---lgavTRLYVSdleaaaeggsqvetdrengpsvi------------vagrltkqslldavghqdgglqaKFYICAGPa 617 Magnaporthe gri...
EAK81232     586 -------RRAITSrhaetigklcvhvfsaglhdnalsisqldgtafdltitfhdarlspdlllslsgreraEVWVCGPPq 658 Ustilago maydis...
XP_389653    557 --lakstTLFVTGqsdkdkeslldeaekagtr--------------------ivkrrvsandvesfkgqsaRFFLCTAPa 614 Gibberella zeae...
EAU86339     588 tnvtiqlPVFFTKgpdtpvvpdntpswlsithh-------------------ptrvtpewlrgssldfkgrELYVCGAPp 648 Coprinopsis cin...
XP_001885680 545 ---avnePTFSLAiyvfskgsvptlavkgvgekvrv-------------ethlqrlskeflvvrgkllvesEVYVCGPGt 608 Laccaria bicolo...
XP_001906176 512 --kqvkvRLFLTGgcgesgkaemakikglegvkv-----------------emrrltkkdvqgdwfdkerkKYFLCAGVg 572 Podospora anser...
Feature 1                                           
XP_001247525 593 l------rkSVTDWLRGk---------rVICEDFD 612 Coccidioides immitis RS
EAT79582     580 l------rgDVLGWLEGk---------kVVFEGFD 599 Phaeosphaeria nodorum SN15
ZP_00955847  630 ---------AFMRWSEAtlitlnveegrRHRESFV 655 Sulfitobacter sp. EE-36
EAA57664     616 f------gdVAVEGLRAvgvp----nerIHREGFY 640 Aspergillus nidulans FGSC A4
XP_001538101 583 l------kaSVLNWLVGk---------kVIYEDFN 602 Ajellomyces capsulatus NAm1
XP_359815    618 a------tkTITEWLVDq---------dIITESFN 637 Magnaporthe grisea 70-15
EAK81232     659 l------etSVVHTLESagwp----tnkLHRESFA 683 Ustilago maydis 521
XP_389653    615 l------laALEEWLQGe---------kVVWEDFG 634 Gibberella zeae PH-1
EAU86339     649 y------ekTIMDSLTSdevgi--skdaVKSEWFA 675 Coprinopsis cinerea okayama7#130
XP_001885680 609 fekvvaevvAELGRSVGd----------VRREGFE 633 Laccaria bicolor S238N-H82
XP_001906176 573 m------mkVLRGWLEGe---------eVVSESFE 592 Podospora anserina DSM 980

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap