1A8P,2BGI,1FDR


Conserved Protein Domain Family
FNR1

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cd06195: FNR1 
Click on image for an interactive view with Cn3D
Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99792
View PSSM: cd06195
Aligned: 53 rows
Threshold Bit Score: 210.114
Threshold Setting Gi: 41614847
Created: 23-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts lie primarily in the N-terminal region
  • Structure:1A8P: Azotobacter vinelandii FNR binds FAD, contacts determined at 3.5A
    View structure with Cn3D
  • Citation:PMID 9865948
  • Structure:2BGI: Rhodobacter capsulatus FNR binds FAD, contacts determined at 3.5A
    View structure with Cn3D
  • Structure:1FDR: Escherichia coli FNR binds FAD, contacts determined at 3.5A
    View structure with Cn3D
  • Citation:PMID 9149148

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #                              ####             
1A8P_A        8 RVLSVHHWNDt--LFSFKTTrnp-slrFENGQFVMIGLevd-----------------grpLMRAYSIASPNye------ 61  Azotobacter vine...
ZP_00590097  24 TVVGKIMVTPd--LMIFRIHtdeareeFEAGQNLLLGLygfekrssnse-pelvpaegeklIRRPYSLASEKtet----- 95  Pelodictyon phae...
ZP_02730387  17 TVVSLRLVNPd--LMILRVKpdaprpeHRPGQYCTLGLgywerrtegcqaeslsegdftkvVRRAYSLSCGIldddgdll 94  Gemmata obscurig...
NP_869439    23 TIIKRMDLTEd--LARFRIQcdepvmpFEPGQYVAIGLgnweprlrgtqpedvpikksrklVRRAYSISCPMlhdaespk 100 Rhodopirellula b...
ZP_01857854  26 SVMDLRMPHDh--LMIVRIKpdedvprFSGGQYTTLGLgswehrvdgg---plaelekpklIRRAYSISCPMldlqgdll 100 Planctomyces mar...
NP_963345     4 KILKREFIDKd--HYLLWVErpk-dynYKPGQFTYIEStin-----------------nnkVRRFYSFASHPee------ 57  Nanoarchaeum equ...
ZP_02062762   9 TLEKSEQIAPdvkHFTFYYEegg-cfqFIPGQFITLHIptd-----------------ekiLRRSYSIANKTypa----- 65  Rickettsiella gr...
AAW73636     30 KLVDRRMIAPtvaHCQFVRDdgq-pldFQPGQFIQIHFdyad----------------gtpTKRSYSLATIHdhalg--- 89  Xanthomonas oryz...
ZP_01128161   9 VLQAARMITPrvrELTFVREdrs-pldYTPGQFITLFIesg-----------------gerLRRSYSIASIPgse----- 65  Nitrococcus mobi...
YP_094515    13 TLEESFMISPkvkHFIFNCElsp-pfeYLPGQFITIHFehd-----------------gknLKRSYSIANEPkkd----- 69  Legionella pneum...
Feature 1                      # # #          # ##                                       #      
1A8P_A       62 ----------ehLEFFSIKVQn--------GPLTSRLQHLKeGDELMVSrKPTGTLVTSdllpgKHLYMLSTGTGLAPFM 123 Azotobacter vine...
ZP_00590097  96 ----------rqLEFYISQVKs--------GQLTSRLFNLNvGERLYVGtKITGIFRLDetpdgSDIVMVATGTGIAPYI 157 Pelodictyon phae...
ZP_02730387  95 -----rledsdwLEFYIVLVRenpd--grvPALTPRLFALSeGDRIYLGdRVTGHYTLDpvrpcDTVLFLGTGTGEAPHN 167 Gemmata obscurig...
NP_869439   101 agelapvdqidyLEFYITLVRqgataaskpPALTPRLFGKGeGDRICVErKITGRYLLGdipadENVLMLGTGTGEAPHN 180 Rhodopirellula b...
ZP_01857854 101 -----andeidyLEFYITLVLrpd---tddPPLTPRLFRLKeGDRLHLGkKPVGTYTLKpvqpgDNVIFAGTGTGEAPHN 172 Planctomyces mar...
NP_963345    58 ----------enLLFYIKRVPn--------GLMSNYLAEIPlGSTIEIG-NPMGHFTLDra-dtDRVIFIGAGTGIAPIR 117 Nanoarchaeum equ...
ZP_02062762  66 ---------tnkIEFAASYVPs--------GVASQLLFTLKpGDKVMAT-GPFGRLTLRee-mpERYILVATGTGVTPYR 126 Rickettsiella gr...
AAW73636     90 --------pgeaVEIAVSFVPg--------GSATALFEGLEiGDQLQAS-GPYGRFCLQpgdhnQRYVLIATGTGVTPYR 152 Xanthomonas oryz...
ZP_01128161  66 ---------seeIRIAATYVEg--------GRATARLFKIEpGERIQAM-GPFGRLVLRed-ppGRYLLVATGTGVTPYR 126 Nitrococcus mobi...
YP_094515    70 ----------nrIEFAAGYFEg--------GPGTELLYNLKpGDVIHIN-GPFGRLIFRde-tpGRYILVATSTGTTPYR 129 Legionella pneum...
Feature 1                                                                                       
1A8P_A      124 SLIQDpe---vyERFEKVVLIHGVRQvNELAYQQFITEHlpqseyfgeavkeKLIYYPTVTRESFh---------nQGRL 191 Azotobacter vine...
ZP_00590097 158 SFLRShi---veRPESKMVVIQGAAHrWDLGYYSELTFLeks--------faNFFYVPTLTDADDrwd------gyRYCI 220 Pelodictyon phae...
ZP_02730387 168 YMTWEll---srRHTGKIVNVCCVRYaRDLGYHNTHQLLaqk--------fpNYSYIPLTTRELGnt--------rKLYI 228 Gemmata obscurig...
NP_869439   181 AMATTll---sgGHRGKVVIATSVRYqSDIAYQSEHDELmrr--------fpNYCYLPLTTREPKnlepnrpdyvgKQYL 249 Rhodopirellula b...
ZP_01857854 173 SMSIEll---krGHTGRIVSMTCVRYkGDLGYLAQQEQLqkq--------fsNYRYGAFTTREPEnmdenhpsyvgKQYL 241 Planctomyces mar...
NP_963345   118 PLTIEa-----vKQNKKVIVVHQERYkHLLVFRDLFEQL-------------PIIYIPILSKEQSe---------yHGHV 170 Nanoarchaeum equ...
ZP_02062762 127 TMLAElehrfklRPCFKVVLLFGVRRpEDLLYRDEFIAFsek--------naWFEFHAYYSRVKLnk-------alSYEH 191 Rickettsiella gr...
AAW73636    153 SMLPLlae-aiaTRGVQVVLLQGARNpTELLYGDDFRAFada--------hpQFRYVPCFSRDVP-----------EQPH 212 Xanthomonas oryz...
ZP_01128161 127 AMLPEler-ridLEGFHVELLLGVRGpEELIYGDEFTAFasq--------cnAFTFRACYSREQPer-------agEFEH 190 Nitrococcus mobi...
YP_094515   130 AMLNElgqriekHPDLQVVILQGVQRsEEILYPDDFQAFakk--------ypQASFRPYLSRVQK-----------QDLK 190 Legionella pneum...
Feature 1                                                                                       
1A8P_A      192 TDLMRs--GKLFEDIGlppinpqddrAMICGSPsMLDESCEVLDGFGLkisprm------------------gepgdYLI 251 Azotobacter vine...
ZP_00590097 221 EELLRk--DVLQNEFNispdp-erthFFVSGQPeMVGHVSEWLSDFGYtrhhp-------------------ddpgeLYI 278 Pelodictyon phae...
ZP_02730387 229 QDLVQs--GELERHLGteldp-atthVFLCGNPrMIGVPVHDRDSGEVrypspvgtveileargftadvaarklkgnVHF 305 Gemmata obscurig...
NP_869439   250 QTMFTt--GKLAELVGdplap-gnthVFLCGNPdMIGYVPPGGDVPDRpgmlpllraagf------hdatetpgpgtIRF 320 Rhodopirellula b...
ZP_01857854 242 QDIIQp--ERFQETFGwspap-dkthVFLCGNPsMIGLPEKNDRGELVfpdskgmvellae---qgytlstpknpgnIHF 315 Planctomyces mar...
NP_963345   171 QDYID---RLIYNDAT----------YYICGSRqFVIEIANLLKSKGIn---------------------------kIVI 210 Nanoarchaeum equ...
ZP_02062762 192 MGYVLnafGEIQPNAKqd-------iVYLCGNPnMVDEVFTLLVKNYGfpt------------------------diIRR 240 Rickettsiella gr...
AAW73636    213 ADVRH---GYVQQHLAefvpdaahdiAYLCGNPdMVDICLEALKAAGLps-------------------------aqIRR 264 Xanthomonas oryz...
ZP_01128161 191 SGYVQ---GILPNMALnpe----rdiVYLCGNPtMIDEATAFLTENGFsm-------------------------rnVRR 238 Nitrococcus mobi...
YP_094515   191 DNEYS---GYVQHAFPelnlnptrdmVYLCGNPgMIDEAFNYLKEHGFsm-------------------------qhIVR 242 Legionella pneum...
Feature 1         #
1A8P_A      252 ERA 254 Azotobacter vinelandii
ZP_00590097 279 EEF 281 Pelodictyon phaeoclathratiforme BU-1
ZP_02730387 306 EEY 308 Gemmata obscuriglobus UQM 2246
NP_869439   321 EKY 323 Rhodopirellula baltica SH 1
ZP_01857854 316 EKY 318 Planctomyces maris DSM 8797
NP_963345   211 EAF 213 Nanoarchaeum equitans Kin4-M
ZP_02062762 241 EKY 243 Rickettsiella grylli
AAW73636    265 EKY 267 Xanthomonas oryzae pv. oryzae KACC10331
ZP_01128161 239 EKY 241 Nitrococcus mobilis Nb-231
YP_094515   243 EKY 245 Legionella pneumophila subsp. pneumophila str. Philadelphia 1

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