Conserved Protein Domain Family
FNR_N-term_Iron_sulfur_binding

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cd06194: FNR_N-term_Iron_sulfur_binding 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99791
View PSSM: cd06194
Aligned: 21 rows
Threshold Bit Score: 219.833
Threshold Setting Gi: 163851454
Created: 2-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #          ####              # # # # ##             
YP_001761127  96 IHEKQYLSDsVVKILVEPsEEVSHSAGQYINLRRFDGLtRSYSITNDPDs-kLIELHIRRKYNGQFSDWLFNhasVGESL 174 Shewanella wood...
YP_001093629  96 IQEKQFINEaVVRVRLVLdEPLAHHPGQYINLRRFDGLtRSYSPTSLPGe-pFLELHVRRKYNGQFSDWLYHhagIGESL 174 Shewanella loih...
AAU91343      96 VTALEPLNSeIMHVSLEChAPLEYRAGQFINLFREPTLgRSYSLASVPQhdeHLHLHVRRLPQGKVSGWIHEhlrIGQTV 175 Methylococcus c...
YP_001758966  95 VAAITPLSKrILSITLDPdTPLEYHAGQFINLRRSDGLtRSYSLASHPAqgdMLEIHVQRIDNGGMSQWIHEqlsLDDKL 174 Shewanella wood...
YP_635033     96 IQALSLLSTsVLRVRLVTdSPLAYHAGQYISLVREDGLaRSYSLASLPHe-dALELHVRLQPGGAMSGWLAHdaqPGDRL 174 Myxococcus xant...
YP_001673894  96 LVERQFVSDsLMKLVIKLsERLDSLPGQYINLRRFDGLtRSYAIVKCLEg-nLIEMHITRKHNGQFSNWLFGtasVGEQL 174 Shewanella hali...
YP_001171686 125 VQSLERLGAdVLRLRLLPeRPLRYRAGQHLLLWTAAGVaRPYSLASLPNedpWLEFHIDSSRPGAFCDFAREl-rPGDLL 203 Pseudomonas stu...
ZP_01908041  105 LEGLERLSPsVMRVRVRPdAAFAFEAGQYVALRRADGVtRSYSIASLPGe-dCLEFHVRRVPNGRMSGWLFDeaeVGARV 183 Plesiocystis pa...
YP_096543     96 IMSLQRLNHnVIQVKLNVeHPAPWLPGQYLSLINPEGTmRNYSIANIPAddgYIELHIKIYPQGKMGQWLLQraaINTFI 175 Legionella pneu...
YP_927982     95 LLDKLSLSEdVTRLIIKPdTRTPYIPGLCTGIRGPEGLgRTYGIAPGQGe-gTFAVHVRRKRNGRFSRWLCDevkVGGSL 173 Shewanella amaz...
Feature 1                                      #                                                 
YP_001761127 175 LIQGPWGDCCYRs----eYKNDTLILIGTGTGLGPVYGIIRDALSQGHKGEIYLYHGAKNeaDLYHHSKLLKLmlehrNM 250 Shewanella wood...
YP_001093629 175 LVQGPLGSRYYRt----aYRDAKLIIVAFGSGLGVAHGMLMQALAQGHQGEIFLYVGARDdnDLYLHPKLLKMmlehrQF 250 Shewanella loih...
AAU91343     176 EIRGPSGDCFYVp----gRPEQELVLIGTGSGLAPLYGILRDALQRGHSGPIRLFHGSRNraGLYLTDRLRELareypNF 251 Methylococcus c...
YP_001758966 175 ELCGPFGHCYYQk----eMQTMPMLLVGTGSGLAPLLGIVKDALHHQHQGPIHLYHGSRTadDLYAQQLLTSLarqydNL 250 Shewanella wood...
YP_635033    175 QVQGPAGSCFYVp----gRPEQPLLLAGTGTGLAPLYGIVRDALAAGHTGPIWLFHGARTpeGLYLTSELRALaeqhpQF 250 Myxococcus xant...
YP_001673894 175 LVQGPLGQCIYKa----eYQTDKLILIGHGSGIGAAVGIVEHALALDHQGDIYLYHDARYiqDLYLHSALLKLslankQF 250 Shewanella hali...
YP_001171686 204 RLGELHGGALHYep---eWCERPLLLLAAGTGLAPLWSLLRESLRQGHRGPIRLLHVCRQ--GHYLKEPLQALarahdNL 278 Pseudomonas stu...
ZP_01908041  184 AVSPPLGTCRYPaqpdaaYLDSPMLLVGVGTGLGPIWGIVRAAFEAGHRAPITLVQAGRTldSLYLGDELDALsaahpGL 263 Plesiocystis pa...
YP_096543    176 TIRGPFGQCYYHnp---hNLAFDILLAGTGTGLAPLIGIIRSALTQKHEGTITLVHGGVTdeDIYYKEELEMLsllfsNF 252 Legionella pneu...
YP_927982    174 SLTRPWGRCNYDg----aYGNDELIVVAFGTGIGPALGLVQSALDSGHQRPISLYHWGKYldDLYLHRTLLKLmlehkVL 249 Shewanella amaz...
Feature 1                                                                                     
YP_001761127 251 TYLACVeqmgsgksstrvqtgdpfevamsfhqfdsqtLSDSPQRVFLCGEPnFVNKGQELVFLNGtpldRIHALSYE 327 Shewanella woodyi ...
YP_001093629 251 HYQACItgqseskgrrvi-------hanpfsealkchQFDRQQHLFLCGEPgLVNESREIAFLNGfpieRIHSLSFE 320 Shewanella loihica...
AAU91343     252 DYVPCVsgeepapglaa---------graheiafmeiPDFKDKRLFLCGHPeMVSAAKRRAFLAGaamkDIYADPFN 319 Methylococcus caps...
YP_001758966 251 HYLGCVsgtqaeekdri----------radelalknhQNLSGWQVYLCGHPdMVNKMKKRTYLAGadikNIFADPFI 317 Shewanella woodyi ...
YP_635033    251 LYRPGVleggsrdvaeg----------aldvliraecPKPLGWRAWLCGDGpLVLSLRKKLFLAGlslkDLHTDAFL 317 Myxococcus xanthus...
YP_001673894 251 NYQACItskaqseqrlpsrc----tygqaadiaaqqhPIGRDCRVFLCGEPlAVNQAQQQAFLDGfeytNIHVLPFE 323 Shewanella halifax...
YP_001171686 279 QLEWISheerdr-------------------mlstlrPTSRRDVALVCGGPsFVDVCARRLYLAGlprgQIFGDAFI 336 Pseudomonas stutze...
ZP_01908041  264 DLRRCVleepsegesstplevgavdalaprlvrddreRRPGDWLALLCGDAsVVHRLRRSLFLAGlsarRIRADAFG 340 Plesiocystis pacif...
YP_096543    253 RYDPCVlqsqglypeg-----------siekrvlthlHSPNNTKVYVCGPKeTTNKLKTRIFLAGvpstNIYSDVFL 318 Legionella pneumop...
YP_927982    250 HYQGLIsassdadridnhrv----rlmdvpqilkerhELGRDKRLFLFGEPdMVAKVTEYAFLCAldmdRIHAQSFE 322 Shewanella amazone...

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