1EP2


Conserved Protein Domain Family
DHOD_e_trans_like

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cd06192: DHOD_e_trans_like 
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FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as NAD binding. NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.
Statistics
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PSSM-Id: 99789
View PSSM: cd06192
Aligned: 30 rows
Threshold Bit Score: 157.874
Threshold Setting Gi: 150020171
Created: 22-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                # ####             ###   
1EP2_B          9 VVSQREVay-----nIFEMVLKgtlvdemDLPGQFLHLavpn---------gamLLRRPISISSwdkrakTCTILYRIGD 74   Lactococcus l...
ZP_01515699     9 IRERRQFd------hLVWKSLIapeiartARPGQFVLVrvsp--------sfdpLLWSVFFLAGadphsgTVELLIDPRD 74   Chloroflexus ...
YP_001547489    5 ILDQQQLnq-----hYGLLTVAspq-lasAQPGQWAMLhhgls-------sdpfLRSRAWIIATnr--ssTATLALDLQD 69   Herpetosiphon...
YP_153761     822 VTSVTYPar-----nIVELTIHspiaarkFKPGQFYRLqnfgsahpyakhtqllMEGVAVTGASvdkengTITVVVLDVG 896  Anaplasma mar...
NP_819616     852 VVDVRRHtp-----dMVECRIRapmaarnFRAGQFYRLqnyeclspliadtrlqTEALAMIGVNesaeadVISFIVLERG 926  Coxiella burn...
YP_506539     937 LLKAEVLevialtnnIYELRICaplaarnFMPGQFYKLqnfh--------spfqIEAIALTGSCvdknngVISLIVIEVG 1008 Neorickettsia...
AAU90388      914 IVAVNRLtp-----tIIEVVVRapaaakhFQPGQFYRVqnyealapvvegtvlaTEGIALTGAWvdkdngLISLIALEMG 988  Methylococcus...
NP_840932     864 VHKVERLts-----nIIEVVVHaplaarhFHPGQFYRFqnyaslagiseqtrlaMEGIALTGASvdvsngLVSLIALEMG 938  Nitrosomonas ...
YP_425657     850 VHAITRHtp-----tIVEITLHapqaarrFRPGQFYRLqnferqaarvdgttlaMEGLALTGAWvdreagLLSVIVLEMG 924  Rhodospirillu...
YP_196244     747 ILDVEHLtk-----nITKLTILaplaaanFKPGQFYRLqnfeynslnientklsIESLALTGVSvdkdkgTISTIVLNAG 821  Ehrlichia rum...
Feature 1           ###                                         #                                 
1EP2_B         75 ETTGTYKLsklesGAKVDVMGPLG--NGFPVaevtstDKILIIGGGIGVp---PLYELAKQlektgcqMTILLGFASen- 148  Lactococcus l...
ZP_01515699    75 SAGGWLAGyp--vGTQLDVCMPVVp-AVTPNlt---tQTLLLAGVGPTLp---ALLFTARQyaa--rlSISLWLTGDe-- 141  Chloroflexus ...
YP_001547489   70 PLLASIGRlp--kGFELDCIGPLG--RPLSSdg---qKATLLIAEGNAIy---SLLLYAQRvtetgspVLLLASANDa-- 137  Herpetosiphon...
YP_153761     897 GSSKLCSQlr--dGQLVSLMGPVG--TPTEIps---dENVMLVGGGVGNa---VLFAVGKAliangckVLYFAGYRSles 966  Anaplasma mar...
NP_819616     927 GSSRLVATlk--pGQPISIMGPTGcyAKIPEgn---sKTIMIVGSSMAAahlrSLGPALRKag---hrVFYVALIEKae- 997  Coxiella burn...
YP_506539    1009 VSSYLCKFlk--vGERVVLTGPLG--TPTEIpv---nENVLLIGGGVGNa---VLFSVAEAmkkngcnVLYFSGYKKln- 1077 Neorickettsia...
AAU90388      989 SSSRLCAQwk--pGDPLVVMGVTG--APTEIps---gQTVALVGGGLGNa---VLFSIGKAlrsagnqVIYFAGYRNsa- 1057 Methylococcus...
NP_840932     939 GSANLCALlq--pGEPVVLMGPTG--TPTEIes---hETVVLVGGGLGNa---VLFSIGAAaraagckVLYFAGYKKla- 1007 Nitrosomonas ...
YP_425657     925 GSSDLCAHlr--lGEPVVLMGPTG--SPTEIga---gETVLLAGGGLGNa---VLFSIGKAmraegckVLYFAGYKGla- 993  Rhodospirillu...
YP_196244     822 GSSHLCNYlk--kNEPIIFMGPTG--TPTEIps---nKNVMLIGGGVGNa---VLFSIGQAllshnckVLYFAGYKKt-- 889  Ehrlichia rum...
Feature 1                                                                                         
1EP2_B        149 -vkILENEFsnl-knvTLKIATDDGsygtkghvgml-----------------------mneidfevdaLYTCGA----P 199  Lactococcus l...
ZP_01515699   142 --gYLPPPFllp--atVEVQTSTGGaaalfnlltvs----------------------rvdnpirwadqIIFALP----P 191  Chloroflexus ...
YP_001547489  138 ---MRVPPFvlp--aeIEYLATADDvldllessak------------------------ldaplvwanrLLAAGSldlaS 188  Herpetosiphon...
YP_153761     967 vfgIRSIEAas----hTTVWCCEDGaikherpedishhgniida------iqaysaaknstiklqsvdrIIMVGS----S 1032 Anaplasma mar...
NP_819616     998 -elYCQEELeaa--sdSILWVSEKDehvdlhrpqdkamqgelis------alrnytlekpaiplesvdqVYVIGP----A 1064 Coxiella burn...
YP_506539    1078 -drFKADMIeaf--sdCVVWVCDEGkfpsnrtcdvslmgnmimal-----ekyirgeillpikagaldrIVTIGS----D 1145 Neorickettsia...
AAU90388     1058 -dvFKAEELeaa--sdLLVWTVDKRegntpipitrpddksfmgniveamlayakgelgptpihlddvdhMIVIGS----D 1130 Methylococcus...
NP_840932    1008 -drYKVAEIeaa--adTIVWCSDEApgfqpsrlgdlsyvgnivqam---vayasgelgsapismqaadrIIAIGS----D 1077 Nitrosomonas ...
YP_425657     994 -drYRIDDIhaa--adTIVWCCDETpgfvperpgdftvtgtivdam---vayaegrlgtppialsevdrVIAIGS----D 1063 Rhodospirillu...
YP_196244     890 --eDIFEPSsieksssNVIWCCNEKrieprrtqdqsyhgniieai----eqyqnhtsqgtniplhsidrIIMIGS----S 959  Ehrlichia rum...
Feature 1                                      ##                                      
1EP2_B        200 AMLKAVAKKydq--------lerLYISMESRMACGI-GACYACVEHdked----eshALKVCEDGPVFL 255  Lactococcus lactis
ZP_01515699   192 QLFGMAVEAirtvrl--rwehgfAQVIVAGPLPCGL-GICRVCQIEtr-------hgWQRCCIEGPVFD 250  Chloroflexus aggregans D...
YP_001547489  189 RLSQRIRREryaw------qqgfAAFIVDQAYPCGI-GMCGGCWQStr-------qqPKLLCHHGPALD 243  Herpetosiphon aurantiacu...
YP_153761    1033 GMMSAISSAvrgklrscfkeqikIVASINSPMQCMMgGICGQCIQRhinps-tgeesFVYSCVNQDQCA 1100 Anaplasma marginale str....
NP_819616    1065 SLLRGIQKAregllkeyfkpkteFIASVYGPMQCMMkGVCAQCLQWqidpatgkrtkAVYACSWQHQPM 1133 Coxiella burnetii RSA 493
YP_506539    1146 SLMSAVQRFidkhrhi-lkpnlkAIASINSPMQCMMqGICAQCIQRrhvn---gkeeYVYSCVNQDQNM 1210 Neorickettsia sennetsu s...
AAU90388     1131 RMMEAVKHArhgllapylkphhaAIGSINSPMQCMMkGVCAQCLCKhvdpe-tgreyFVYSCYNQDQEL 1198 Methylococcus capsulatus...
NP_840932    1078 RMMAAVAAArhqqlapylkvehfAVGSINSPMQCMMkEICAQCLQPqkdpv-tgdisYVFSCFNQDQPL 1145 Nitrosomonas europaea AT...
YP_425657    1064 RMMRAIAEArhgvlaphlnsrhvAIGSINSPMQCMMkEICGQCLQPltdpq-tgetrIVFTCFNQDLPL 1131 Rhodospirillum rubrum AT...
YP_196244     960 HMMDAVSYAifnqyrhffkqdikVIASINSPMQCMMkEICAQCLQKhinpi-tkeeyFIYSCKNQDQPA 1027 Ehrlichia ruminantium st...

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