1QFJ


Conserved Protein Domain Family
flavin_oxioreductase

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cd06189: flavin_oxioreductase 
Click on image for an interactive view with Cn3D
NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN, or riboflavin via NAD(P)H. Flavin is used as a substrate, rather than a tightly bound prosthetic group as in flavoenzymes; weaker binding is due to the absence of a binding site for the AMP moeity of FAD.
Statistics
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PSSM-Id: 99786
View PSSM: cd06189
Aligned: 59 rows
Threshold Bit Score: 234.751
Threshold Setting Gi: 74317788
Created: 11-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts lie primarily in N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #          ####             ### #   ###       
1QFJ_A         5 CKVTSVEAITdtVYRVRIVPda----aFSFRAGQYLMVVMDErdkRPFSMASTPdekGFIELHIGASeINLYAKAVMdrI 80  Escherichia coli
ZP_01166719  107 CDITANEKLNhdVYRIRLRMpatasmsAEYFAGQYLDMYLPDgqkASFSIGSAPdagRDLELHIRHVpDSELSTAILdhL 186 Oceanospirillum...
ZP_01306288  103 MQIESVKPLNdfTYQVQLLSpag--klPQYHAGQYLELLIDDn-qYPFTIASKPn-gRHIELHLGVSeDNASSIAIRnyL 178 Oceanobacter sp...
YP_001342823   6 ATVNAVESINpnVYQITLKVd-----dLTFEAGQYLIVALPTgeqVPYSIGSAPhelPYLTLYVLVSdSASLASKVVehI 80  Marinomonas sp....
ZP_01116480   13 ATVHDIKPLSgdVWQVLLKPlt----nYPYQAGQYTELLIDGfqfLYFTIGSAPh-tPCVELHIQGGsETNNRLIEH--L 85  Reinekea sp. ME...
NP_747313     95 CSVSECVDVGgdVWRVRLRApag--kpLRYHAGQYLMIEREGgkqAAFSLASAPhagRELELHVLAR-EPSAVQLIDq-L 170 Pseudomonas put...
YP_431625    102 FQIKAVTALSddVYQVQLLApag--alPEFFAGQYLELLAPGveaAFFSIANAPg-tREVELHIQVHqESRSALAIYqyL 178 Hahella chejuen...
ZP_01076186    6 AKVNKVELINqnVYQVSLDVp-----vDSFIAGQYLMIHLPSgesVPYSIGSAAhelPSLQLYILVAdEASLAFKVIsyL 80  Marinomonas sp....
ZP_01894748  103 AKVVDVRSIShdVYRVELQLprr--reLSFHAGQYLSVNLPDadpCYFSIASSPs-eDLIELHIQATpEWVSAQKVIdaL 179 Marinobacter al...
YP_125302      8 AQVEDISPLTdsIVRLVLMPde----yVDYQAGQYLQILFANd-aFSYSIANAPlgsHRYELHIRHSqDNDYHQSLLahI 82  Legionella pneu...
Feature 1                                            #  #                                        
1QFJ_A        81 LKDHQIVVDIPHGEAWLRdd-----eeRPMILIAGGTGFSYARSILLTALArnpnRDITIYWGGREEqHLYDLCELEALs 155 Escherichia coli
ZP_01166719  187 LNEKTVEIELPKGDCYLQahsi--gadTRLIMAAASTGFAQIKSVVEHLLAnqfsNQIHIYWGARVEeDMYLEKLPEQWa 264 Oceanospirillum...
ZP_01306288  179 QNHSTVRVKLPGGNVWLKpgmdsfnlhDPLIFVVAGTGFAQAKAMIEDQLEhq-hSAIYLYWINRDQ-DGFYSNLPQQWh 256 Oceanobacter sp...
YP_001342823  81 KSNNSITIKAPGGDCHIAngal-dstpENILLIAGGTGFAQIKSLYSHLVEqnftGNVSFYWGLRTPeDVFAQEWLEEAh 159 Marinomonas sp....
ZP_01116480   86 KQNNAVDLAPANGRCTLDylp---esaSPLLLIASGTGFSQVKSIAEHLIHiqstRKVFIYWTSYKLsQLYMLERAEAWa 162 Reinekea sp. ME...
NP_747313    171 RRDGLARIEMPFGDTHLAel-----pdGPLVLIAAGTGMGQMHSLVEHCRAqgfkHPVHLYWGVRRPeDFYQIEHWDEWq 245 Pseudomonas put...
YP_431625    179 TSESVVRARLPLGKCFISgv-----pdMDVSLIAAGTGFAQIKSIVEYLLAqgfeRKLSIYWGVRQSqEMYARALSEAWa 253 Hahella chejuen...
ZP_01076186   81 KDNENVNLKIPGGDCHIDngal-kdsvDQVLLVAGGTGFAQMKSMYDALTEqkyqGKVSLYWGVRTPeDSFLVDWIESQd 159 Marinomonas sp....
ZP_01894748  180 TSGGEVTVELPHGRACLAsa-----pdKPLLLVAAGTGFAQMKSLVDYLQKtsydKPVKFYWGVRRHeDMYLRSLAQQWq 254 Marinobacter al...
YP_125302     83 KQYGSLRLRLPLGECSIDqlh----pqKPILFIAGGTGFAPIKAMIEQLLAdsdsRPFELFWGARSQsDLYMDEKVRSWg 158 Legionella pneu...
Feature 1                                                                                    # #
1QFJ_A       156 lkhpGLQVVPVVEQpeag--wrgRTGTVLTAVLQDHg---TLAEHDIYIAGRFEMAKIARDLFCSERNareDRLFGDAF 229 Escherichia coli
ZP_01166719  265 aehpNVHFEPIVSEpekspgwngRTGLLPEAILEDFs---DFDDVEIFTSGSPAMVYALLDACEARGFk-eENMHSDVF 339 Oceanospirillum ...
ZP_01306288  257 e-dkLIHYVPMTPEqvdg--pfySDQNVEELVQKQVs---DISRIRVVACGSPNFVYSVLDGLENKGFe-qRQMLSDVF 328 Oceanobacter sp....
YP_001342823 160 k-ytPFTLDVIVNEkgdk--whgRSGWLYEAVLADHp---DLSKSVAFISGSVGMVYGTLDQLELKGLs-kENCFSDVF 231 Marinomonas sp. ...
ZP_01116480  163 eqhaNIHSAMLISEhshw--edkHQMLVHSILADHS----DIGQCQAVTCGSPEMVYTVLDTLCEHGFr-eENMIADVF 234 Reinekea sp. MED297
NP_747313    246 r-lpNLFLHQVVSDlcg---wegRCGMLHEAVCEDIa---DLNSVHVYASGSPNMIYATLDALVEAGMd-aHRMRADVF 316 Pseudomonas puti...
YP_431625    254 erheNVSFTPVMADnrd----neWQGHHAELVRAVLaerrHWDNSLVYVSGSPTMVYTAMDALAPLGLp-gEQFFSDVL 327 Hahella chejuens...
ZP_01076186  160 ----NISLVANEAEadw----qgTTGWLYEKIVADNp---DLSRSVAFVSGSPGMVYGTLDKLEEAGLa-hDASFSDVF 226 Marinomonas sp. ...
ZP_01894748  255 eewpPFTFLPVVGDded----neWSGHHDQLVRTVLasgmDWNNVEVHASGSPTMVYTLMDALLEVGLp-qEAFFSDVL 328 Marinobacter alg...
YP_125302    159 shasHFQYFSLLSDk--------SEDTLASRVLARHa--nILRDWQIVISGPFDMVYSTRDTLVGYGIs-pTQMFSDAF 226 Legionella pneum...

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