Conserved Protein Domain Family
NOX_Duox_like_FAD_NADP

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cd06186: NOX_Duox_like_FAD_NADP 
NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX has a 6-alpha helix heme-binding transmembrane domain fused to a flavoprotein with the nucleotide binding domain located in the cytoplasm. Duox enzymes link a peroxidase domain to the NOX domain via a single transmembrane and EF-hand Ca2+ binding sites. The flavoprotein module has a ferredoxin like FAD/NADPH binding domain. In classical phagocytic NOX2, electron transfer occurs from NADPH to FAD to the heme of cytb to oxygen leading to superoxide formation.
Statistics
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PSSM-Id: 99783
View PSSM: cd06186
Aligned: 243 rows
Threshold Bit Score: 72.3374
Threshold Setting Gi: 50292097
Created: 7-Sep-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #                  ####  
Q9Y5S8       297 ITKVVMHP-----------SKVLELQMnkr-----------------gfSMEVGQYIFVNCpsi-----slLEWHPFTLT 343 human
XP_001528756 250 SLKIINVPs----------SSLQIVKIplpt--------------qnfpVWSPGSHIRINYsyani-kswiGPTHPFTLS 304 Lodderomyces el...
XP_001485841 222 FIKFQTYSatpvslkevpnSSLVLVSFpwpd--------------hiatSFKPGSHVRINHsnrsw-kswvFASHPFTSA 286 Pichia guillier...
XP_460762    240 ISDLKVISye--------gSNLIVVRIqrdl---------------kiaDWPSGSHIRLTYpltny-rswiFPTHPYTIA 295 Debaryomyces ha...
XP_001382308 255 LHDISVVE-----------SPYSKMQIiripr------------petfpSYLPGSHIRLGYsatni-sawlYATHPFTIA 310 Pichia stipitis...
XP_448481    256 TSRASLIEkied----rknTNLVVLKFprka---------------lpdFFNPSSHIRLSAyrklnplywiLPSHPYTLA 316 Candida glabrat...
P53109       248 IVFAKSLMilnkn-anyskTNLVHVRLprai---------------lpdYFEPGSHIRISPyrrinplywlLPSHPYTIA 311 baker's yeast
XP_456107    249 NVTQRVKDd----------TSLTYVKLdrs----------------airDWLPGSHLRLSKykkknplywlMPTQPYTIA 302 Kluyveromyces l...
XP_756986    325 ASRLRLAPsass----slvSSYMNLEDatkqcstsssrslcngpmlagaRIGAGDDVRITIprl-----qwVGDHPFSVF 395 Ustilago maydis...
XP_720990    247 SLKVIDIPt----------STLQIIKIpqpn---------------kfpNWLPGSHIRLNYtiskf-kswtTATHPFTIV 300 Candida albican...
Feature 1                         ###        ####                                                
Q9Y5S8       344 Sapee-------dffSIHIRAA------GDWTENLIrafe---------------------qqysPIPRIEVD------- 382 human
XP_001528756 305 Stye--------dqnKFLLLIM------RKTANFQFk----------------------------PEKTYLLT------- 335 Lodderomyces el...
XP_001485841 287 Tlpg--------tseTLDLVVKk-----GTFIFAKD-----------------------------TQYNLSSPyt----- 319 Pichia guillier...
XP_460762    296 Sles---------deMLDLIIS------KSNRFILH-----------------------------PQMPYSWT------- 324 Debaryomyces ha...
XP_001382308 311 St------------nDDSESTLd-----LVMNKPVNfp-------------------------idITSPYTMT------- 341 Pichia stipitis...
XP_448481    317 Tlpsd-------eivELIVNEHtv--pqFNTSSFVVe----------------------------LGYSYTIQ------- 352 Candida glabrat...
P53109       312 Slaed-------nsiDLIIKETstaepgSQIESLRS-----------------------------NPKSFHLDqektytl 355 baker's yeast
XP_456107    303 Slpde-------sqiDLIIREN------LTPYVVVGe---------------------------yTVVDVYST------- 335 Kluyveromyces l...
XP_756986    396 AvgrcktgnpdmgyvDLVIQRQa-----GLTQKLSQlaqelstyttdesrrpsdmylqqavrrkgQRVRVVID------- 463 Ustilago maydis...
XP_720990    301 Tiped-------sanNLTLIVK------KPTQFVVY-----------------------------PLDSYLLT------- 331 Candida albican...
Feature 1                                 #                                                      
Q9Y5S8       383 -GPFGTas--edVFQYEVAVLVGAGIGVTPFASILKSIwykfqcadhnlktkkIYFYWICRETga-----------fsWF 448 human
XP_001528756 336 -GPYPAlpa-pfFSTLQVVNILCGGSGISFGLPLFQYFksts-------pntvINLVWSVRNKad------------lFI 394 Lodderomyces el...
XP_001485841 320 sLSFDDn----lISRFDQSVIICGGSGISLAIPVFKYLitk----------ldVTMIWCTRSK---------------AD 370 Pichia guillier...
XP_460762    325 -GPFTSfsk-elLQTIDNVDIICGGSGISFALPVFRNLkqk---------ashVKLIWCVRSN---------------ND 378 Debaryomyces ha...
XP_001382308 342 -GPFPSlpp-qfYTTARHVNIICGGSGISFGLPIYKYFvnsn-------rsipIRLIWCIRSSdd------------tFI 400 Pichia stipitis...
XP_448481    353 -NPHNPsvpdvcLQNANRIAIVCGGSGIAFGLPLFRFFksmk-------nisyLRLVWLTKNSsqlsi-----itksdSF 419 Candida glabrat...
P53109       356 iNSYPPsvpeecYSQGTNIAIICGGSGISFALPLFRHFfnke-------nvkyLKMIWLIKDYseyelvldylktnglTF 428 baker's yeast
XP_456107    336 -VPPSL------LYDSQRVAIVVGGSGISFGLSIFKYLqtrn--------ldyLKFIWLIRER---------------ED 385 Kluyveromyces l...
XP_756986    464 -GPFGRsp---sLEGAQHAILVAGGIAITFCYPLLVRAargef-----nsletCKLVWIVRNEgi-----------ldVL 523 Ustilago maydis...
XP_720990    332 -GPYPSlap-pfFTTANIVNIICGGSGISLGLPIYHHFrsin-------stvpVKLVWTVRNQnd------------tFI 390 Candida albican...
Feature 1                                                                                        
Q9Y5S8       449 NNLLts--leQEMEelgkv-gflnyRLFLTGwdsnivghaalnfdkatdivtglkqk----------------------- 502 human
XP_001528756 395 RNSV------DLTDv----------QVYVTStidegetdenvnstqfvvedehdeenygllnndnndnnnneeevveeeq 458 Lodderomyces el...
XP_001485841 371 LFVLr----hYSLLdk--------vQVYITGndslsvedeseghglmhetielenleesskn------------------ 420 Pichia guillier...
XP_460762    379 LHVLr----tLNFNee--------iIIHITGnlqdstsntifdeedyglldydnnenfeleslpssetpsrtv------- 439 Debaryomyces ha...
XP_001382308 401 LDHLlp---eRSIDv----------QIYITSntgslnqqqsastifdeeadallegdsttniemanlat----------- 456 Pichia stipitis...
XP_448481    420 RALI------SEDGkid------nlDIYLTNkttaptssgteetendieledfelnttedlte----------------- 470 Candida glabrat...
P53109       429 EKKL------SNNKr---------iSVFISGeytaetrldeittniddenseyemgsfnnededlsisnfnsenadsnd- 492 baker's yeast
XP_456107    386 MHILnhcnfeTNDL-----------EVYVTRslppddtqtksmnangssefddidfeletmdesgal------------- 441 Kluyveromyces l...
XP_756986    524 RDSLse--llDEIRnrggsrcslsiDIYTTVkasapslggsiavdmks-------------------------------- 569 Ustilago maydis...
XP_720990    391 MNQL------DMTGv----------QVYVTSigdtnsesqenqqhqavplfvieeeeeeeghgllnnesengielqnmpe 454 Candida albican...
Feature 1                                                                                        
Q9Y5S8       503 -------------------------------------tsfgrpmwdnefstiatshpksvvgVFLCGPrtlaKSLRKcch 545 human
XP_001528756 459 qqegielhtlhkqssgtdasttskegtkllkvgenywlgrpkldevfalhnptlthdpkcswVVACGP----DGLIKdak 534 Lodderomyces el...
XP_001485841 421 -------------------------------seatkqpeilrgrpdlnnvcaslettpnsscVISCGP----RSLVKdce 465 Pichia guillier...
XP_460762    440 --------------------nddslsqdtrpkkeskfiivqgrpdfgntfeslvqvnssnkwIIACGP----RSLVNsaq 495 Debaryomyces ha...
XP_001382308 457 -------------------------dkeekktdhfntihdgrpnfddafgnlaaavdvdekwLIACGP----RKLIDdcr 507 Pichia stipitis...
XP_448481    471 -------------------------------ykklcnitegermdwttelsslveedtsktwLLACGP----EGLVTdgk 515 Candida glabrat...
P53109       493 ---------------ntpetshsptkengsmievkskhsftlsnelksfnnesaqvnqnetwLFSCGP----PSLLQlsk 553 baker's yeast
XP_456107    442 --------------------------ltndskspslvhfgrrldwqvdlaqfieshalqnswLVCCGPe---SLLTDger 492 Kluyveromyces l...
XP_756986    570 ----------------------------------------------aaqlpsrpeatqlrskLMSAGStssiAASSKe-- 601 Ustilago maydis...
XP_720990    455 sn----------eensetntinsknnkdneerkeyfkfgrpkfdevfaiddpttthdldnswVIACGP----DELISdak 520 Candida albican...
Feature 1                           
Q9Y5S8       546 ryssldprkvqfyFNKENF 564 human
XP_001528756 535 twa----kdhnyqFFSEKY 549 Lodderomyces elongisporus NRRL YB-4239
XP_001485841 466 nwc----rnhkieSVTEIY 480 Pichia guilliermondii ATCC 6260
XP_460762    496 ewa----senkvnFVSEIY 510 Debaryomyces hansenii CBS767
XP_001382308 508 kwt----kgkdieFYSELY 522 Pichia stipitis CBS 6054
XP_448481    516 sya----nangihFASEVY 530 Candida glabrata CBS 138
P53109       554 kyc----nderinFVCETY 568 baker's yeast
XP_456107    493 yak-----qnycnFVKEFY 506 Kluyveromyces lactis NRRL Y-1140
XP_756986    602 -------------FGSSHQ 607 Ustilago maydis 521
XP_720990    521 rws----kdrgyrFYYEKY 535 Candida albicans SC5314

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