1GVH,1CQX


Conserved Protein Domain Family
flavohem_like_fad_nad_binding

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cd06184: flavohem_like_fad_nad_binding 
Click on image for an interactive view with Cn3D
FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The hemoglobin domain adopts a globin fold with an embedded heme molecule. Flavohemoglobins also have a C-terminal reductase domain with bindiing sites for FAD and NAD(P)H. This domain catalyzes the conversion of NO + O2 + NAD(P)H to NO3- + NAD(P)+. Instead of the oxygen transport function of hemoglobins, flavohemoglobins seem to act in NO dioxygenation and NO signalling.
Statistics
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PSSM-Id: 99781
View PSSM: cd06184
Aligned: 129 rows
Threshold Bit Score: 222.433
Threshold Setting Gi: 172041370
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Structure:1GVH: E. coli flavohemoglobin binds FAD, contacts determined at 3.5A
    View structure with Cn3D
  • Structure:1CQX: Cupriavidus necator flavohemoglobin binds FAD, contacts determined at 3.5A
    View structure with Cn3D
  • Comment:FAD contacts are primarily in the N-terminal sub-domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   #               ####             # # 
1GVH_A       147 GGWEGTRDfr--iVAKTPRSalITSFELEPVDGgavaEYRPGQYLGVWLkpegfphqeIRQYSLTRKPDgk-gYRIAVKR 223 Escherichia coli
YP_001525667  32 SGWRAFTV-----AERHPETaqITSFHLVPADGgappVHKAGQHLTLRLsdp---srlIRNYTISTAPNgh-hWRISVKR 102 Azorhizobium ca...
ZP_00049038  152 GGWNGWRDfv--vESVTPESeiIRSFVLVPADGgpvlRHEPGQYLGFLLdlpg-rgvlKRNYSISCAPNdr-aYRITVKR 227 Magnetospirillu...
ZP_01897854    3 ETFKSFTI-----LKKHKEStlVTSFHLTPTDGsslwDAEPGQYLTLRIptgt--gfvLRSYSISGDVEnlqsYRISVKR 75  Moritella sp. PE36
YP_001600777 155 GGWTGWRPft--vRRRTRESetVTSFELVPVDGapvmRHRPGQYLSFRLdvpg-lgsqRRNYSISSKPDdg-sYRISVRR 230 Gluconacetobact...
YP_528901    327 RVYKQFKI-----IKKIKESrdVTSFYIRPLDGsalsSYLPGQFLPISIkqphtsstcLRTYTLSQAPLsn-aYRFSVKR 400 Saccharophagus ...
EDQ07681     152 GGWKGWRDfv--iAGIIGESasVKSFVLRPVDGgpvlRHQPGQYLAFDFdhpd-tgkaRRNYSISCAPNge-yYRISVKR 227 Phaeobacter gal...
YP_191291    155 GGWTGWRPfr--iARAVPECanVTSLELEPVDGkpviSAVPGQYLGVDLdipd-rgrtRRNYSITSSPNrk-gYRISVRH 230 Gluconobacter o...
YP_001309398  11 NKWKGFKDflvykTVKEDEV--VTSFYLKSLDGsklpEFIAGQFITVRIknedntftkPRQYTLSMNSNee-fYRISVKR 87  Clostridium bei...
YP_572513    149 GGWEGTRTfr--iAAKRPESavITSFVLAPVDGgpvaAHRPGQYIGFKLtidg--eivHRHYSLSASPDgk-tYRVSIKR 223 Chromohalobacte...
Feature 1                    ####                                         #                      
1GVH_A       224 Ee---------gGQVSNWLHnhANVGDVVKLVAPAGDFFMavaddTPVTLISAGVGQTPMLAMLDTLaka----ghtAQV 290 Escherichia coli
YP_001525667 103 E-----------GAASTWLHdaLRVGDTLEVAGPGGDFVLpssaeRPLVLVSAGVGVTPMVAMLEEAvaq----gwsGPL 167 Azorhizobium ca...
ZP_00049038  228 Eakte----hpaGLVSNWLHdaAIAGTVLKVAAPAGDFFLdrssnAPVVLVSGGVGLTPMVSMLESItet----tpeRPT 299 Magnetospirillu...
ZP_01897854   76 EtanvdwegaldGIGSCWLHdlAKIGDEIDISAPRGQFVLdnnsvRPIVLLSAGVGLTPLVSMLHSLkk------reNDV 149 Moritella sp. PE36
YP_001600777 231 Ip---------gGAVSGWLHddVREGTVLQVSAPAGDFTLadplpPAIVLLSAGVGLTPMISMLDALaar----adaPSI 297 Gluconacetobact...
YP_528901    401 Ek---------fGLASRILHdtINTGDSLYVSQPEGKFTLqt-nkKTNVLLSAGIGITPMIAMLQGLirevekgekpQDV 470 Saccharophagus ...
EDQ07681     228 Ep---------gGVISGWLHevATEGTVLRVAAPAGDFVLkdrpeGEVVLLSAGVGLTPMVAMLETLaa------ndRSA 292 Phaeobacter gal...
YP_191291    231 Vs---------nGAVSGWLNsgKCEGMEVLLSPPAGNFVLpekveGPLAFVCAGIGITPMIGMLEALaqp----gvtTPV 297 Gluconobacter o...
YP_001309398  88 Ee---------nGYLSKKLCdeIKAGDNLQITAPLGNFILkd-seKPLVLIGGGIGITPMLTMAYDAvn------sdRKI 151 Clostridium bei...
YP_572513    224 Ee---------gGKVSRHFHdrLAEGDTLELLPPAGHLTLde-gtSPVMLISAGVGQTPMVPLARQAla------agRRV 287 Chromohalobacte...
Feature 1                                                                                        
1GVH_A       291 NWFHAAENGdvHAFADEVKELGqs--------lpRFTAHTWYRQpseadra-kgqfdseGLMDLskleg------afsdp 355 Escherichia coli
YP_001525667 168 HFIHCTRDAahQAFAEHVADLLak--------lpAGRSDIFYSRapqagl---ganqhgGRVTLdflrt------qtplg 230 Azorhizobium ca...
ZP_00049038  300 WFVHSALNGrvHALREHVRNLAan--------rdNLRVRIFYTApeaqdrv-geaydipGPVTAewlva------ntpse 364 Magnetospirillu...
ZP_01897854  150 WFIHVCDNSdvHAFKSEVNNIAves-------lgRIRTHLIYRHpthq-------deelGLFDSqdvidrqliqsllpld 215 Moritella sp. PE36
YP_001600777 298 HYIHATRTPdtEAFGRHVRRLAae---------gRIRGDVFYSRrapadgedagtahhtGRMTMdwlra-------nlaa 361 Gluconacetobact...
YP_528901    471 YFIHSTQNSetHTFANELKHLNkr--------hkWLQLYTIYSQpklndkl-gqhydvsGRISLdllrk------ilptd 535 Saccharophagus ...
EDQ07681     293 TYLHAAVDGdnLAMEGLSKSLAkrsvifletpsdADRAAARYDVe--------------GRITPdwlaa------ntnta 352 Phaeobacter gal...
YP_191291    298 HVVQIAHSAetAPFAERLAELShns-------agRIRVVTRLTEk-------------dGHPTAawvae-------qlpg 350 Gluconobacter o...
YP_001309398 152 HFIYSIPNSthHSFKEETVKLHn----------nNFKSNVFYTRpkenekl-gkdfdvqGRISEkwmid-------nlpk 213 Clostridium bei...
YP_572513    288 AYLHAARDGavHAFADELARLEady-------paLLEVITVYSQpraed-----apthgGHVDAnllsr-------ylpr 348 Chromohalobacte...
Feature 1                                          #    
1GVH_A       356 TMQFYLCGPVGFMQFTAKQLVDLGvkqenIHYECFGPHK 394 Escherichia coli
YP_001525667 231 DADYFLCGPADFLRDMARGLHEAGvdrarIHYEFFGPPE 269 Azorhizobium caulinodans ORS 571
ZP_00049038  365 QATYYLCGPKSFLASLANGLVRAGipaerVRFEFFGPAD 403 Magnetospirillum magnetotacticum MS-1
ZP_01897854  216 DYDLYLCGTESFMSAMFQLFRSIGlpterIFYEFFGKAK 254 Moritella sp. PE36
YP_001600777 362 DATYYVCGPDGFMRDAVSTLKAAGvpagrVRHEFFGSAH 400 Gluconacetobacter diazotrophicus PAl 5
YP_528901    536 NFDVYLCGSESFMRSSYTNLKAMGiaesrIFYEFFDDGS 574 Saccharophagus degradans 2-40
EDQ07681     353 LSDYYICGPKGFMAMAIAGLRAANvdmdrIHFEFFGPAE 391 Phaeobacter gallaeciensis 2.10
YP_191291    351 GVSTYLCGPTGFMHDMVHGLPAAGvpaerLRYETFGPDT 389 Gluconobacter oxydans 621H
YP_001309398 214 DGDFYFCGPVPFMKTVYHNLISMAiekenINFEMFEAGV 252 Clostridium beijerinckii NCIMB 8052
YP_572513    349 DAQCYLVGPAGFMRNMEAALSALGvaasrRHHEFFGPAE 387 Chromohalobacter salexigens DSM 3043

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