Conserved Protein Domain Family

cd06169: BMC 
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Bacterial Micro-Compartment (BMC) domain
Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shell at present no experimental evidence directly supports this view.
PSSM-Id: 132884
View PSSM: cd06169
Aligned: 23 rows
Threshold Bit Score: 40.7062
Threshold Setting Gi: 150388110
Created: 8-Jan-2008
Updated: 2-Oct-2020
Aligned Rows:
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Hexamer interface [polypeptide binding site]
  • Structure:2A10; Synechocystis sp. CcmK4 forms a hexamer; contacts defined at 3.5A.
    View structure with Cn3D
  • Structure:2A1B; Synechocystis sp. CcmK2 forms a hexamer; contacts defined at 3.5A.
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #        #  ##     #    #              #                        
2A10_F         6 AVGSIETIGfpgILAAADAMVKAGrITIVGYIRag----------saRFTLNIRGDv-QEVKTAMAAGIDAI 66  Synechocystis sp.
3CGI_A        45 AIGILTITPseaSIIACDIATKSGaVEIGFLDRf-------------TGAVVLTGDv-SAVEYALKQVTRTL 102 Salmonella typhimurium
Q834L9       146 AIAYLIAPPl-eAMVGLDAAMKAAdVQMGVFYGpps--------etnFGGALLTGSq-SACKAACSAFEQVI 207 Enterococcus faecalis
Q55550       139 TLFVLEVQPaayASLAANEAEKSAsINILQVSSig-----------sFGRLYLGGEe-RDIKAGARAAIAAI 198 Synechocystis sp. PCC 6803
Q8XLY2         4 SIGALEFRSiskGIEVSNEVVKKAfVEVSYLKSic----------pgKFFLIVNGDa-GEVKEAIEFGEKLG 64  Clostridium perfringens
YP_849307    149 AFGIIVGGPagiGVVMADTAVKSAnVDVVAYSSpadgt-----sfsnEVILCISGDs-GAVRQAVISAREIG 214 Listeria welshimeri ser...
YP_001321606  34 ALGLMQGKMi-dMIHASDIAEKTAgVMVSDINGscp---------qnMIMIAIWGDt-SSVESAFDEIKREL 94  Alkaliphilus metallired...
CAO90458      36 ASLWIEISPgieINRITDIALKSAvVRPGVLFVer-----------lYGLLELHSSsqGEVRAAGQAILQYL 96  Microcystis aeruginosa ...
YP_001559744  35 SLGIITADSddvTYTGLDEATKAAdVEVVYARSfyggaanantklagEVIGIIAGPspAEVRSGLNACITFM 106 Clostridium phytofermen...

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