3B4R


Conserved Protein Domain Family
S2P-M50_SpoIVFB_CBS

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cd06164: S2P-M50_SpoIVFB_CBS 
Click on image for an interactive view with Cn3D
SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain. SpoIVFB is one of 4 proteins involved in endospore formation; the others are SpoIVFA (sporulation protein, stage IV cell wall formation, F locus, promoter-proximal A), BofA (bypass-of-forespore A), and SpoIVB (sporulation protein, stage IV cell wall formation, B locus). SpoIVFB is negatively regulated by SpoIVFA and BofA and activated by SpoIVB. It is thought that SpoIVFB, SpoIVFA, and BofA are located in the mother-cell membrane that surrounds the forespore and that SpoIVB is secreted from the forespore into the space between the two where it activates SpoIVFB. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown.
Statistics
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PSSM-Id: 100085
View PSSM: cd06164
Aligned: 58 rows
Threshold Bit Score: 179.657
Threshold Setting Gi: 156743100
Created: 23-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteputative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                  ##  #                 
3B4R_A         8 FKIMGIPIELHITFILFLVVIIGLSim------------nnSIFWAVLFILLFVSVVLHELGHSYVAKKYGVkIEKILLL 75  Methanocaldococ...
YP_289871     21 GRPWGIPVYITPSWVVIAVLLTFLYqpvvdsi--lhlgaasYLVALLFAVLLYVSVLIHELAHCVAARHYGLpVRSITLY 98  Thermobifida fu...
YP_947914     21 GRIAGIPVYLAYSWFVIAAFTVIVYgpvlmdym-pylnnwaYFVALCIALLLALSVLIHELAHALSAKAFKWpTEKIVLN 99  Arthrobacter au...
YP_872939     21 GYVFGAPVIVGPSWLLFLAWITWQFapvvadav-pgiregrYLVSACFGVFLGLSVLAHELAHLVAARWFGIpSDRIVLT 99  Acidothermus ce...
YP_001104473  20 CRVAGVPVLLSPSWWVGAAVIVLLYtplvgrllpgatsltsGLVAAAFTVLLALSVLLHELGHCLVALRLGLpVRRVRLF 99  Saccharopolyspo...
ZP_00995317   18 ARIGGVPVQIGASWLLLAAVITYIVgsgape-----lgavaYVVGVAYAISLLVSVLVHEGAHAGMARALGFpVHRVVAD 92  Janibacter sp. ...
YP_923827     17 GTIAGSDVLVSSSWFLVAGLIAIIVapvvdqaq-pglgawkYVAGVAFAVILYLSVLLHEASHAIAARHFGFpVSSITLH 95  Nocardioides sp...
ZP_00381357    4 GTVLGAPVILAWSWFLAAIVITILFapwvntvr-pdlgvwaWFVAFAYAVLLFASVFLHELAHGVAGQFYGLkVAAIELN 82  Brevibacterium ...
Q9RJ56         2 GRPFGVPVYVAPSWFLVAVLITWVFggqldrvl-pelgaarYLVSLFFAVAFYASVLVHELAHTVAALRFKLpVRRIQLQ 80  Streptomyces co...
YP_001625188   2 GRIGGVPIILAYSWFIIAGFTMLVFgpqlseny-ptlgvgaYLVAFVYALLLLFSVLVHELAHALAARAYHWpTQKIVLN 80  Renibacterium s...
Feature 1                                                                                    #   
3B4R_A        76 PIGGVAMMDKIP-------KEGELRIGIAGPLVSFIIGIVLLIVSqffdin-----ingypLLYTLSLLNLMLGGFNLIP 143 Methanocaldococ...
YP_289871     99 LLGGVSEIDREAe-----qPRQEFWIAFSGPLLSLVLAGLGFLCYllvdpa-----tvlgvLIWQLWVANLLVGVFNLLP 168 Thermobifida fu...
YP_947914    100 LWGGHTQFENFTa-----sPGRSVVVALAGPASNFLVAGVMWAVMstdlls-----gvsatLGDILMRANLLIGIFNILP 169 Arthrobacter au...
YP_872939    100 ALAGHTALSREPd-----rPRRMFVVALSGPLANLLIAAAAAAAHrvlpah-----tvsavLTAGLAWTNGIVGVYNLLP 169 Acidothermus ce...
YP_001104473 100 LLGGITEISRTPp-----rPGQEGVVAVAGPAVSIALAGLTGVAWlalppg-----gavwlLVAQTCVANLAVGVFNLLP 169 Saccharopolyspo...
ZP_00995317   93 LWGGHTAYDARLs-----tPGRAAAIAVVGPVANGALALVAWIASlavsa------dvpsrILFGIAFVNLLLAGFNLLP 161 Janibacter sp. ...
YP_923827     96 FLGGMTAIEGEAr-----kPRQEFFIAVVGPLTSIAVGAIALGLRpltpe------glllmAVEGLAGANLLVGVLNLVP 164 Nocardioides sp...
ZP_00381357   83 IWGGFTRFEPQAdnprdkaALTSFVISIVGPIVNIVLALLGWWCLsavspt-----svpwlLLIAVTFANVALGAINLLP 157 Brevibacterium ...
Q9RJ56        81 FFGGVSEIEKEAe-----tPGREFVLAFVGPLLSLVLSGVFYAALlpvepd-----svagvLLAGLMVSNLIVAVFNLLP 150 Streptomyces co...
YP_001625188  81 LWGGHTQFENFTa-----tPWRSLVVAFSGPLANFVLAAVGYLVYlslpdgvgtpdrvlnlLLNIFVWANLLIGAFNVLP 155 Renibacterium s...
Feature 1            #                                                                           
3B4R_A       144 AFPMDGGRILRAILSkky-gylKSTKIAANIGKSLALIMLLFGLls------------------mnIILILVSLFVYFGA 204 Methanocaldococ...
YP_289871    169 GLPLDGGRILRAAVWaasgrplTGTTAAAWGGRILAILVIALPFvyswllwr------aapsivtvLWTTLLGAFIWRNA 242 Thermobifida fu...
YP_947914    170 GMPLDGGRLVESAVWkatgsqdKGTIAAGWSGRIIVVVLVILFIgvplisga-------wpdltfiVITVLVCGFLWMGA 242 Arthrobacter au...
YP_872939    170 GLPLDGGQMLRALVWaitrrprLGVLVGAWSGRLVGLATVLFGAylftrre--------pnaqldgLWALLIGGMLLMSS 241 Acidothermus ce...
YP_001104473 170 GLPLDGGRMLRALTWavtgrrhAGTTAGVVGAGAVAVGLIVWALvgllgna--------ddqwlrlGVCVLLAWFVVAGA 241 Saccharopolyspo...
ZP_00995317  162 GLPLDGGQLVDALVWkltgrreKGLIAAGWTGRVVTLGVIGWFVvrplvegs-------qpsltsiIWMGLICVFMWQGA 234 Janibacter sp. ...
YP_923827    165 GLPLDGGRVLKSLVWrltgsphRGTIVAGWGGRLTAAAVLFWPAfqepvlgt-------epdildfVLAFVIAAFLWSGS 237 Nocardioides sp...
ZP_00381357  158 GIPLDGGWALQALMWrltgsqyLGTIVASWVGRVIAIGFIGWSVitpllage-------rpdpltvAWMSLIAIMLWFSA 230 Brevibacterium ...
Q9RJ56       151 GLPLDGGRMLRAVVWkltgkpmSGTIAAAWVGRALAIAVLIGLPlltqslgsdaaddvgmdtvmdaLLAAILAAIIWTGA 230 Streptomyces co...
YP_001625188 156 GLPLDGGRLVESIVWritgsqeKGTVAAGWAGRVVVVLLVFTVLgvpllvrq-------plniqtaLFSLFIAAFLWVGA 228 Renibacterium s...
Feature 1               
3B4R_A       205 EQESRVV 211 Methanocaldococcus jannaschii
YP_289871    243 SVALHTA 249 Thermobifida fusca YX
YP_947914    243 SSSIHHA 249 Arthrobacter aurescens TC1
YP_872939    242 GAVLRQQ 248 Acidothermus cellulolyticus 11B
YP_001104473 242 GAEHNAE 248 Saccharopolyspora erythraea NRRL 2338
ZP_00995317  235 TGAIRTG 241 Janibacter sp. HTCC2649
YP_923827    238 TAAMASA 244 Nocardioides sp. JS614
ZP_00381357  231 GDAATHA 237 Brevibacterium linens BL2
Q9RJ56       231 GNSLRMA 237 Streptomyces coelicolor
YP_001625188 229 SQAITTA 235 Renibacterium salmoninarum ATCC 33209

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