3B4R


Conserved Protein Domain Family
S2P-M50_SpoIVFB

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cd06161: S2P-M50_SpoIVFB 
Click on image for an interactive view with Cn3D
SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) is one of 4 proteins involved in endospore formation; the others are SpoIVFA (sporulation protein, stage IV cell wall formation, F locus, promoter-proximal A), BofA (bypass-of-forespore A), and SpoIVB (sporulation protein, stage IV cell wall formation, B locus). SpoIVFB is negatively regulated by SpoIVFA and BofA and activated by SpoIVB. It is thought that SpoIVFB, SpoIVFA, and BofA are located in the mother-cell membrane that surrounds the forespore and that SpoIVB is secreted from the forespore into the space between the two where it activates SpoIVFB.
Statistics
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PSSM-Id: 100082
View PSSM: cd06161
Aligned: 86 rows
Threshold Bit Score: 122.265
Threshold Setting Gi: 160914224
Created: 23-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteputative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ##  #                                    
3B4R_A        15 IELHITFILFLVVIIGLSimnnsifWAVLFILLFVSVVLHELGHSYVAKKYGVkIEKILLLPIGGVAMMDKIP---KEGE 91  Methanocaldococ...
YP_001513293  10 EVKTSYSIIFILIFSMIFn------YFYKLLILIAVVFLHELSHCFMCIYYGIqVKEIKLFVFGGVAKFLGDIegnSKQE 83  Alkaliphilus or...
ZP_02076445    7 KLCISKLWLVALPLFIYLh------LTKYMCFIFLILSFHECAHILVAWLMGYeFEKIVIYPFGLSASIRNIGhgkLIKE 80  Eubacterium dol...
NP_622560      2 KVKVHFSTFVFGLLLIFLg------FVKELFSIFLVVCVHETGHVLAAKKLKVeVLEVNIYPFGGVAFLDPTVfirPDLE 75  Thermoanaerobac...
YP_001307645   1 MKKWYMVLILELSILMWLg-----dYEGYIVISFLWVILHEFAHMIVASKFGCkFNNVNISIFGAKVELSDIDeltERKK 75  Clostridium bei...
YP_001394274   1 MIKINKYFIPYIILLIVVg------YRGQIIYTAIVVFFHEIIHYLFSRYYKFsGFGIEFIAVGAVIKLKDLDeafPKED 74  Clostridium klu...
NP_782628      1 MIKINKYFLPYVIILLMLg------FREKIIISFILVFLHELVHCLVAKALGFkGFNIEILPVGAVLKLKDIDeasAKED 74  Clostridium tet...
YP_878595      1 MIKISKLSIPYIIILLIIg------FKGKMIVSFIFVFFHEMVHYITAKKLGFkGFGIEILPIGAVLKLRDLDeadPKED 74  Clostridium nov...
YP_001255485   1 MVKINKYFIPYVVFLFYLg------YKGSFLLSISVVFVHELIHYVTARYLGFtGFNIEIYPLGLSLKLDKLEnanFKED 74  Clostridium bot...
Q97JM1         1 MFKLSKYFIPYMIILFFIg------FRGEIFSVVILVIIHEFTHYLTARMFGFsGFDIEILPFGAVLRLKKIDyatQKED 74  Clostridium ace...
Feature 1                                                        #       #                       
3B4R_A        92 LRIGIAGPLVSFIIGIVLLIVSqffdiningypLLYTLSLLNLMLGGFNLIPAFPMDGGRILRAILSkkygylKSTKIAA 171 Methanocaldococ...
YP_001513293  84 IAIALAGPLLNFILILISFAVLrlgnk--pwqeNMEFFITVNLSIGLFNLMPMLPLDGGRVFRGLLApylgikKATYMVI 161 Alkaliphilus or...
ZP_02076445   81 IVIIIAGPLSQLVFVVLFPHWAsigl---isdgFAKYLKMINANIMVFNLLPIYPLDGGRLLQSFFHsfltyqKAQKWTL 157 Eubacterium dol...
NP_622560     76 ILIALAGPFFNIFFAFLSELFSqif------diRLDYFIKANLIMAFFNLLPGLPLDGGRILKSFLSyflslrSAILVST 149 Thermoanaerobac...
YP_001307645  76 MILYLAGPFFNIFMAVVMCYLYgyf-----kyqIIEDSIKVNFFLGAFNLLPAYPLDGSRVCEILLSkkllykRSKKITE 150 Clostridium bei...
YP_001394274  75 LIISISGPIFNLIFSGLFYFMYkiv-----ysnFCYVFFSINLAIGLFNLIPAFPLDGGRILRSILNlkipyrMANKITI 149 Clostridium klu...
NP_782628     75 LIIALSAPLLNIFLGVLFYFLYrih-----gheLLYIFFQYNMVIGGINLIPAFPLDGGRIVRDIIRgktvykVANKITV 149 Clostridium tet...
YP_878595     75 LIISLSGPLFNLIFAMIGYFLNikf-----sseYLQLLYISNLALGTFNLIPALPLDGGRILRDILAmktfykRANKITV 149 Clostridium nov...
YP_001255485  75 LLISLSAPIVNIFFAIIFCIAYgvy-----nnnSLYLLYKSNLIIGVFNLMPALPLDGGRILRDLLCfktfyrRANEITI 149 Clostridium bot...
Q97JM1        75 IIISLSGPILNLILAVIFYVIFkns-----grhIYYSLYFTNLSLGLFNLIPAYPLDGGRIMKEVLSekipyrKANEVSI 149 Clostridium ace...
Feature 1                                                       
3B4R_A       172 NIGKSLALIMLLFGLls-------mnIILILVSLFVYFGAEQESRVV 211 Methanocaldococcus jannaschii
YP_001513293 162 RLGYILCILLFSIGIyltfv--ynieYAFLSALAVYIGLSNAKEKSR 206 Alkaliphilus oremlandii OhILAs
ZP_02076445  158 ATSMAILLGIVVSSLlkgwsalvielFLAVQLIMTWLQLPYDRLAFY 204 Eubacterium dolichum DSM 3991
NP_622560    150 YGTYLISFSLLWVSFkdisq--vsrnVLYTFLAVLLVIAANKEKKMS 194 Thermoanaerobacter tengcongensis MB4
YP_001307645 151 IFSFIISGTLFLIFIiimil--hkvnISLFLAVILITYATFIEKEKT 195 Clostridium beijerinckii NCIMB 8052
YP_001394274 150 VISIIIGIMLMLVYVflfln--ghnnFTIGIIATFIMTTSLKENERT 194 Clostridium kluyveri DSM 555
NP_782628    150 YISIFIGIILMGIYLflffa--gnnnISLGIIALFIMISSLNEKNRM 194 Clostridium tetani E88
YP_878595    150 NISLVIGMLIYVYFCistvl--gmknISIGIIGIFIVIISYKEKERI 194 Clostridium novyi NT
YP_001255485 150 NISIGISVFFMVLYIflfmk--gynnFNLGIISLFITGFSLKEKERV 194 Clostridium botulinum A str. ATCC 3502
Q97JM1       150 YISIVIGIIFCIFSIvglff--svksINMLVVAFFILFCSFKEKGRM 194 Clostridium acetobutylicum

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