Conserved Protein Domain Family
S2P-M50_like_2

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cd06160: S2P-M50_like_2 
Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.
Statistics
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PSSM-Id: 100081
View PSSM: cd06160
Aligned: 48 rows
Threshold Bit Score: 89.5966
Threshold Setting Gi: 74533386
Created: 23-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active siteputative
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          ##  #                                         
Q98KS9       184 VGFAVLSALILWPFFglhlgGLALAAILTSVVALHELGHMAAFRLMGHrKARMIFIPlLGGIAIGGRpy-nsRFEVAFVA 262  Mesorhizobium ...
YP_528779    135 VALLAASVGVYSVIF-----TPQFAVALVAILMFHEYGHIRGMKKFGIpTKGIYLIPfFGGMAIGEKhk--sQWQDVYIS 207  Saccharophagus...
ZP_01090572  277 ITMLVISFLLFAAAIgw-qqDFTALLLLAPILLFHEAGHFLAMKLFGYrDTKMFFIPfFGAAVSGRHln-vaGWKKGLVS 354  Blastopirellul...
ZP_02012980  284 LLLMLVSLALFMLALhw-imSPTLAITLVIALTVHECGHLLGMRLFGHrDTQLLFLPfFGGAAVAHDplvlaPWKHLVIL 362  Opitutaceae ba...
YP_437886    271 ALLLLVSLGAFMLSFgf-rmDAPVLLILVAVLFLHEFGHLLAMKVCGFrDLQILFIPfLGAAARGDKdq-apAWQKVIVD 348  Hahella chejue...
ZP_02133430  235 IGRFILSAAAFVAAFtw-lwSFENALLLLLVIFIHEIGHYLAMGLFGYkNRQVFFVPfLGAATMGAKdd-atIMQRVWVL 312  Desulfatibacil...
YP_518025     98 FATTAVSMVATIWIYav-fyGAKFALGFVALLFVHEMGHYLTAKRVGLaVSGPVFIPfVGALIGMKEnp-kdAVTEAQVA 175  Desulfitobacte...
YP_001393784  99 FASTLISMLLMILVYak-iyGWAFGLGFVVLLFVHEMGHYLSAKAVKLdVTLPLFIPfVGALISMKEep-kdAVTEAKVA 176  Clostridium kl...
YP_001113168  72 FAGTIISMALTIVIYaq-vyGWFFAIGFVASIFVHEMGHYITSKKIGMnVTAPMFIPfIGAFIGMKEap-rsVKEEALSA 149  Desulfotomacul...
NP_977891     38 VFSMFLSLGAYAVIY-----GWQFGVALIYLLFIHEMGHLWAAKRKGIpTSPAIFIPfMGALIGMKEmp-knAKDEAYIA 111  Bacillus cereu...
Feature 1                                                      #       #                         
Q98KS9       263 LMGAGFSAFLVPIAIAASafagseghkaaaalLAALAGCAALFNIANLVPVWKFDGGQVLRQICPgpvalaLASFFLLSA 342  Mesorhizobium ...
YP_528779    208 MMGPVYGLIMTVVFYLIYsftg-------shfAGLVASISALLNLFNLLPVHPLDGGRVIKALVFsyrnywALLILLTLS 280  Saccharophagus...
ZP_01090572  355 MAGPVPGIFVGGAIGIWAlfqp-------adwKFQLALATLLINGLNMLPILPLDGGAFWQAILFcrhrflDVAFRGAAI 427  Blastopirellul...
ZP_02012980  363 FLGPLPGIFIGIGMMLWStgdp------tlswIWDAGLLTLIFNAFNLLPILPLDGGQIADVALLsrvphfRALFMILSA 436  Opitutaceae ba...
YP_437886    349 LMGPAPGLILGIALCFYLplda-------pdwMTRAVFMLIVLNYFNLAPVQPLDGGQLWNLLFFrrwpmaQFIFFCLSI 421  Hahella chejue...
ZP_02133430  313 LGGPAPGLLLGVICMLLFfhth-------ndfMLMLGAMFLVINYLNLLPITPFDGGKILDALFFdrfpraQFFFFLGSI 385  Desulfatibacil...
YP_518025    176 YGGPLFGSLAAVLCLAFYwltg-------yelALVLAYVGFFLNIFNLLPVHPMDGGRIVSAVSPy-----LWLVGIPVL 243  Desulfitobacte...
YP_001393784 177 IGGPLIGSLGALICFILYfslk-------enfLMALAYTGFMLNLFNLIPLHPLDGGRIVSAISPk-----LWLIGIPIA 244  Clostridium kl...
YP_001113168 150 LGGPLAGAFATLICLTFYyltk-------tpyWVGLAYVSAFLNLFNLLPFGPLDGGRITKALSPm-----IWVIGLVLT 217  Desulfotomacul...
NP_977891    112 YMGPLFGLLSFLPAIPLYmitk-------epfWALIILLGSMINFFNLIPVSPLDGGRIISVVSTr-----IWGAGLVLL 179  Bacillus cereu...
Feature 1                                 
Q98KS9       343 FLAVGWEagf--ssgFLLATGAVFS 365  Mesorhizobium loti
YP_528779    281 AGCAVLSamf--gfyFLVFFIVLGV 303  Saccharophagus degradans 2-40
ZP_01090572  428 AGLGLIAlat--gsyLFGFIGITMA 450  Blastopirellula marina DSM 3645
ZP_02012980  437 LGLIALGalsggaaiILTLLGLFML 461  Opitutaceae bacterium TAV2
YP_437886    422 LAFAAFSwws--qeiVLGLVALFWM 444  Hahella chejuensis KCTC 2396
ZP_02133430  386 FILASCGlll--sepILLFIAVIFS 408  Desulfatibacillum alkenivorans AK-01
YP_518025    244 LYLMITSfn-----pILLIVVILGV 263  Desulfitobacterium hafniense Y51
YP_001393784 245 AIALFKFfn-----pIILLLLVLGI 264  Clostridium kluyveri DSM 555
YP_001113168 218 IVLIIKLks-----fILVLVLIVGI 237  Desulfotomaculum reducens MI-1
NP_977891    180 LGYSIYFks-----iLGGFIFIIGC 199  Bacillus cereus ATCC 10987

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