Conserved Protein Domain Family
S2P-M50_like_1

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cd06158: S2P-M50_like_1 
Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.
Statistics
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PSSM-Id: 100079
View PSSM: cd06158
Aligned: 97 rows
Threshold Bit Score: 77.9721
Threshold Setting Gi: 121726673
Created: 6-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active siteputative
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ##  #                                                             
O25299             14 TLMKILALLIAIIGHEIMHGLSAFLFGDRSTKDArRLSLNPIRHLD--MMGSVLLPalllifqapflFGWAKPVPvdmry 91  Helicobact...
YP_001108559       39 VLIVLGGWATSLCLHEFGHALTAYRGGDLSVRSKgYLSLDPRHYTD--PVLSIVLPllf-----vaiGGIPLPGGavwin 111 Saccharopo...
REF_jgi:Sare_3543  52 FLFVVSGWLVSLCLHEYAHALVAFRAGDRSVAHQgYLTLNPLKYSH--PLLSIAFPvlv-----vllGGIGLPGGavwvd 124 Salinispor...
Q9RKR8             44 FLFVTAAWVVSLCLHEYAHARTALHSGDISVGAKgYLTLNPVKYTH--ALLSIVLPvlf-----vimGGIGLPGGavfie 116 Streptomyc...
Q9A325             75 FAFVAAAWVLSVGIHEFGHAFTAYKAGDTTIVEKgYLTLDPLKYSD--LFTTIIIPlva-----lalGGIGFPGGavylr 147 Caulobacte...
YP_288549          73 FLLLLGGWLICLTLHQYVRSLLAYRGGDRALRGSgYLKLNPFAFRE--LGAQVVLPvaf-----lllGTFGLNGPavhvd 145 Thermobifi...
Q58028             35 FIISLIAVGSGFIFHELMHRTVARKYGAWSEFRA-WYEGLILGFILklVFGATFIApg--------aVYIYKDYLtp--- 102 Methanocal...
ZP_02192940        39 LIIALIAVGTGFIFHELGHRTVAKHYGAWSEYRA-WYEGLAIAMILrvILGITFIApg--------aVYISKDYLty--- 106 Methanococ...
O27067             47 LPATLITVGLGFVLHEIAHKLMAIRYGFWAEYRL-WLEGLLLALVTa-YFGFVFAApg--------aVYIHGNYIer--- 113 Methanothe...
Q97ZW1             46 IIIPYIVALLAIIPHEIGHRQAARRYGCFSRFTL-SFSGFWTTLILn-IIGSFVGIlvf------fsGYTSISCGlln-- 115 Sulfolobus...
Feature 1                                                                                      #      
O25299             92 ivsqkgslaCVVVSLAGVAYNFTLAVLLAFIThwsfqqlginalsidelnlyqlalvtfLIQGILYNLVLGVFNSLPIPP 171 Helicobact...
YP_001108559      112 hhalrtrrvESMVSLAGPLTNLVLGIALTAVVvsvpmp---------------eglgsgLSYLAYLQVIAFVLNILPIPG 176 Saccharopo...
REF_jgi:Sare_3543 125 rhaipgrlrHTLVSLAGPATNVVFTLVLVVAVrlaatggg------------pvefwaaVALLAFLQLTASLLNLLPVPG 192 Salinispor...
Q9RKR8            117 rgrirgrwrHSLISAAGPLTNVLFAVVCTAPFwldaldgv------------prdfrlaLAFLALLQVTAAILNFLPVPG 184 Streptomyc...
Q9A325            148 edlmrsrgwRSLASLAGPLGTLVVLVVIAVSLplaaas---------------pplfnaLSLLAMLQASALVLNLLPVPG 212 Caulobacte...
YP_288549         146 rs-avtrpfRVLAALGGLATNVVLAAVLAVTVallvpagqv----------tnnwaigaVMFLCFLNVSAALLALLPVPG 214 Thermobifi...
Q58028            103 -------eeNGKIALAGPLTNVALAFVFFILMlifkpg---------------sllywiGIFGFHINLFLAGFNMLPIPP 160 Methanocal...
ZP_02192940       107 -------eeNGKISIVGPLINFGLAFIFLIPMvlsvsmn-------------niylwtlGSAGFLVNITLAWFNMLPIPP 166 Methanococ...
O27067            114 -------dvNGKISLAGPLTNIILAIMFLMVStvlps-----------------pinqvAFLGYAVNSFLALFNLIPLAV 169 Methanothe...
Q97ZW1            116 ------rdvEGKTALAGPLTNIIVGFVGLIGAslvpfs----------------lvglfFFELARFNFWVAFFNLLPFWV 173 Sulfolobus...
Feature 1              #                                          
O25299            172 LDGSKALGFlalhfksafllewfskmerYGLLVVFIFLFIPPLS 215 Helicobacter pylori
YP_001108559      177 LDGYGAIEPwlsgpare----fgekarpWAPLVLFALILATPLG 216 Saccharopolyspora erythraea NRRL 2338
REF_jgi:Sare_3543 193 LDGGNMIQPwltppyrr----aydlfapYGFLLLFALLWNPRIN 232 Salinispora arenicola CNS-205
Q9RKR8            185 LDGYGVIEPwlsynvrr----qveplapFGLLIVFALLWIPALN 224 Streptomyces coelicolor
Q9A325            213 LDGYGVIRPflpegvqa----rmmkverVGFLILFALIFWAPGV 252 Caulobacter vibrioides
YP_288549         215 TVGYDILTEavnrwrp------srnaaiFGTVLLFAAVWCPPIH 252 Thermobifida fusca YX
Q58028            161 FDGEKVLKWn-----------------pFIWAIVGLPLIGYMLY 187 Methanocaldococcus jannaschii
ZP_02192940       167 FDGSKVLSWn-----------------kGIWLGVFAVFTVFWLF 193 Methanococcus voltae A3
O27067            170 LDGAKVFRWn-----------------pLIWLLAAAAAFGLTFN 196 Methanothermobacter thermautotrophicus str. De...
Q97ZW1            174 LDGLKIFRWn-----------------mIVWAVLIIIAFALTFL 200 Sulfolobus solfataricus

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