Conserved Protein Domain Family
eu_AANH_C_2

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cd06156: eu_AANH_C_2 
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100013
View PSSM: cd06156
Aligned: 26 rows
Threshold Bit Score: 87.3847
Threshold Setting Gi: 116059781
Created: 7-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##  # #                  # # ##                                                 
EDP50284     529 YSQAMSIplrg-----------aerIVYIAGQIplepasmqmvcdsapteerswlsdYSLRAVLSLQHMWRIGVTMqv-- 595 Aspergillus fum...
XP_761143    458 YSQGIVQa----------------eKIWISGQIgllpad------------lslpedEHLQTALSIQHVRRIYKAMmndm 509 Ustilago maydis...
XP_567575    407 YSQAVLVa----------------sRLHLAGQIplipasltlp-----lapalpkspYPHQATLALQHVGRIVQALksrn 465 Cryptococcus ne...
XP_781466    471 YSQAVQIv----------------sLVFCAGSIalcpsnm-----------tiieggINAESRLSLRSVARVLAAMhpgm 523 purple urchin
XP_421214    441 YSQSIKVg----------------dILYCAGQIglvpctm-----------klvsggVWTEAAVALSHVEKVLQAMsqkt 493 chicken
AAH73100     435 YSQAVRVg----------------pGLFCAGQIalkpctm-----------qlvsggATVEAQVSLLHVERVLDAInpgt 487 African clawed ...
NP_572749    610 YSQSTRIg----------------dITYISGQIalvpgsm-----------tiieggIRPQCKLTLRHISRIAKAMnahg 662 fruit fly
XP_001641550 107 YSQAVKAg----------------aLMFVSGNIglwpasm-----------klvdggVSTQAALSLRHVDRIVSAFsahg 159 starlet sea ane...
AAX25178      29 YSQAIAVpisniqlddcstscvthyFTFYSGQIglipelealpt--ksghfpshfdaLQAESWLSLRHCHRLMKYMsptd 106 Schistosoma jap...
CAL55488     448 YGQSISVd----------------gLAYVAGQIgmeptt------------ldlvpgIVPQLERAMRSAVAVADITgap- 498 Ostreococcus tauri
Feature 1                # ## # #                             #  #                               
EDP50284     596 -------dWWLGAVAFItgae---------------niaaKAQVAWHIWETMnrkrddesideeessfdvwdikygrrte 653 Aspergillus fum...
XP_761143    510 ggrhvdkgWVEGGLCWVdd-------------------edMVEIARRAWISQcdgqdqedeesereea------------ 558 Ustilago maydis...
XP_567575    466 atgggwegWVEGAVGWWaksgd-------------gesgeGVQVTRDAWRIWtrrn------------------------ 508 Cryptococcus ne...
XP_781466    524 -----glnHVVMATCYVte-------------------pgSEVSARRHWDQAlkeekhqlee------------------ 561 purple urchin
XP_421214    494 -----tlrHVITAICYVtd-------------------skHIPVAHSIWKKKlrdctkvedp------------------ 531 chicken
AAH73100     488 -----tlaHVLLVQCYVtn-------------------rsYIPIALAAWAGKnehe------------------------ 519 African clawed ...
NP_572749    663 -----qlrDVVHGICFVth-------------------paFIGEARRQWERRtt-------------------------- 692 fruit fly
XP_001641550 160 -----nlrNTLSGVCYLtc-------------------aqHIPVARKAWSLAtrakrald-------------------- 195 starlet sea ane...
AAX25178     107 -----lwmNLFLGICYAad-------------------esSLSYARNCFHQAvclqtlditd------------------ 144 Schistosoma jap...
CAL55488     499 -----lgaRSLAVTLYTnakyedeyaaagasahpanvmfeSFSREVDSSDRVfs-------------------------- 547 Ostreococcus tauri
Feature 1                                ########         # # # 
EDP50284     654 eqtpkatvsasipnfevlrssgvtPPFLAVQVeelpraSDIEWQGLG 700 Aspergillus fumigatus A1163
XP_761143    559 --------kawlgqpstgesrlppMLFVVLPRhclprsAAIEWQITA 597 Ustilago maydis 521
XP_567575    509 --------------------ggerAPIAFVQAkelpkgALVEYQVNL 535 Cryptococcus neoformans var. neoformans JEC21
XP_781466    562 --------------ldsneypsipCLMNCVVVpslpkgGCVEWHVVA 594 purple urchin
XP_421214    532 --------------eaynevaaecGMLAVVVVtnlprdAAIEWHVTA 564 chicken
AAH73100     520 ---------------------adlAPVTVAIVpmlprgASVEWHVIA 545 African clawed frog
NP_572749    693 -----------------------nAIMDYIVLpalpreALVEWQVWA 716 fruit fly
XP_001641550 196 ----------------ddssddvdGLMAYIVVpnlpkeALVEWQVAC 226 starlet sea anemone
AAX25178     145 ---------------tygdtchcnKCVVWFIVsnlpknASVEWQWIT 176 Schistosoma japonicum
CAL55488     548 ----------------------wrPLVTQLVVtdlpkgAIGEIEPIL 572 Ostreococcus tauri

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