Conserved Protein Domain Family
eu_AANH_C_1
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cd06155: eu_AANH_C_1 
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100012
Aligned: 30 rows
Threshold Bit Score: 91.1645
Created: 16-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ##  # ## # ##                                        # ## # #          #  #   #
XP_421214    306 SSGKSVTGYQWFSCITAqfhps--kdknAQEAAREAFSSLQATITSEglk--lkDIILVHLYMKSmkDFNVINSVYVTEF 381 chicken
XP_321119    418 RAIVNSKGWMWVAGVQGcg-------qdSRQAMASALATLEEMIQSHsft--lrQICYITLYVRNmtEYSFINEIYSTVF 488 Anopheles gambi...
XP_781466    325 SCQCSNQGFAWVYGVRAtckae-ystssILLSTQVAMETLNEQLQSNgys--lkDAVLIHLYVRNmsDFASINSVYCQYF 401 purple urchin
NP_001085655 304 SSDRSQSGFQWISEIKTng-------gnVLEASHMGLSSLKDQAQELglq--msDAVLVHLYVKSmeDFAEINTVYGTHF 374 African clawed ...
NP_572749    462 RAAINAKGWMWLAGIQGsgt------egIEQGMQQALDTLRDLCQAKgyd--lqDLCYVTLYVRSigEYPLLNRVYHRAF 533 fruit fly
XP_395061    327 IVNKNQTGWFWFGGIAGkh-------pdAKSAMREALEKLSSLVKKEnlq--isDIVAVTLYIKDmsNYISINEVYISCL 397 honey bee
XP_001653809 284 LIEKVTNAKQRRSEQCHga-------etSSQAMEIALKTLEDLITSNsft--lrQICYITLYVRDmnEYSYLNAIYSEKF 354 yellow fever mo...
XP_642320    335 SSTTTKINDNDIDNDKDdy--------nIGELLDKALLNISNILKENsls--idQLLYVNLYISDmkDFSIVNQYYYKYF 404 Dictyostelium d...
CAL55488     315 LVRYVTIERGSVANVSCsarpmdgrdatHETCAEAIFQCMGELVRNMpvsttfkKIAMTHVYLDDmsQFAKVNAVYSKYM 394 Ostreococcus tauri
XP_761143    323 PSIRRKGRYFGMSNVTGvtsss--thtsVEDQVKNAFNTIKELLTSSckglgmeHVTHINLYLGTqtLFGRINSMYRTMF 400 Ustilago maydis...

Feature 1            #########          # # #  
XP_421214    382 d-lCPPARVCVETllp--dgVLFCIDCLAH 408 chicken
XP_321119    489 afpNPPTRVCVECplp--adCAVVLEAVAF 516 Anopheles gambiae str. PEST
XP_781466    402 k-lNPPARVCVQAdlp--egTALQLDCLAH 428 purple urchin
NP_001085655 375 l-sAPPARVCVQCclp--dnASLKMDALFC 401 African clawed frog
NP_572749    534 dfhNPPTRVCVECplp--dgCHVVMEAIAY 561 fruit fly
XP_395061    398 skiNPPVRVCVECpl----nIHVVLDAIAY 423 honey bee
XP_001653809 355 gftNPPTRVCVECplp--enCHVVLEAVAF 382 yellow fever mosquito
XP_642320    405 k-nNPASRACIEIplskndkTKFLIDCIGA 433 Dictyostelium discoideum AX4
CAL55488     395 psiEPSARACVATcls--sgSKVQIDCVFV 422 Ostreococcus tauri
XP_761143    401 g-vSPPTRACVALasl-prgCDLMINAVAF 428 Ustilago maydis 521

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