Conserved Protein Domain Family
YjgF_YER057c_UK114_like_5
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cd06153: YjgF_YER057c_UK114_like_5 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100010
Aligned: 25 rows
Threshold Bit Score: -1
Created: 17-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ##  # #               # # ##                                                   #
NP_745914    261 FSRAVAIlgd---------aqaMVFVSGTASIIGAksv-hvGNIEQQTRQTLENINNLLSARllsdydcy--patsgleS 328 Pseudomonas put...
YP_825014     39 FVRGMRIdln---------gltILLISGTASIDENgvsvhiGDFRAQLRRTYQNITGLLEAEgat------------whD 97  Solibacter usit...
NP_813340    266 FERGKSLsdh---------qqeMIYISGTAAIRGEesi-vtGDVLVQTEITLENIQHLIGLEegrekl------pehsgK 329 Bacteroides the...
NP_811388    264 FERGTYVdyg---------drrQVFISGTASINNKgevvypGDIRRQTERMWENVEALLKEAect------------fdD 322 Bacteroides the...
ZP_02013078   40 FSRTVEIaesdgagetgegggrHQLVSGTASIDPAgrtahvGDLDAQIDLSLRVVAAILESRgmg------------wtD 107 Opitutaceae bac...
ACB75503     278 FSRGMTLaie---------grkIVHISGTASINSAgasthvGDAECQSLETLMSIAAILEEQggs------------lkN 336 Opitutus terrae...
YP_900492    272 FERGTSVafg---------drkHIFISGTASINHKgeimhrNDVVRQLNRTFVNIMALLADAgag------------meN 330 Pelobacter prop...
YP_001302022 260 FERAKSMtfq---------drkLIYISGTAAIRGEesl-tgVGLERQLRITMENIAELIADA-----------------K 312 Parabacteroides...
ZP_01054981  217 FARGTLRraptlv----ggagtRFFLSGTASIRGAdti-wpGDIGRQITTTMENIRFLISDEnpqmaqq---gqamdlaS 288 Roseobacter sp....
ZP_02929065  198 FARAVLVteg---------gttTGYLSGTASIEGHrtv-geGDWHTQFRTTMHNIEIMFDRMdmmealrgpeaaakagiV 267 Verrucomicrobiu...
YP_825014     39 FVRGMRIdln---------gltILLISGTASIDENgvsvhiGDFRAQLRRTYQNITGLLEAEgat------------whD 97  Solibacter usit...
NP_813340    266 FERGKSLsdh---------qqeMIYISGTAAIRGEesi-vtGDVLVQTEITLENIQHLIGLEegrekl------pehsgK 329 Bacteroides the...
NP_811388    264 FERGTYVdyg---------drrQVFISGTASINNKgevvypGDIRRQTERMWENVEALLKEAect------------fdD 322 Bacteroides the...
ZP_02013078   40 FSRTVEIaesdgagetgegggrHQLVSGTASIDPAgrtahvGDLDAQIDLSLRVVAAILESRgmg------------wtD 107 Opitutaceae bac...
ACB75503     278 FSRGMTLaie---------grkIVHISGTASINSAgasthvGDAECQSLETLMSIAAILEEQggs------------lkN 336 Opitutus terrae...
YP_900492    272 FERGTSVafg---------drkHIFISGTASINHKgeimhrNDVVRQLNRTFVNIMALLADAgag------------meN 330 Pelobacter prop...
YP_001302022 260 FERAKSMtfq---------drkLIYISGTAAIRGEesl-tgVGLERQLRITMENIAELIADA-----------------K 312 Parabacteroides...
ZP_01054981  217 FARGTLRraptlv----ggagtRFFLSGTASIRGAdti-wpGDIGRQITTTMENIRFLISDEnpqmaqq---gqamdlaS 288 Roseobacter sp....
ZP_02929065  198 FARAVLVteg---------gttTGYLSGTASIEGHrtv-geGDWHTQFRTTMHNIEIMFDRMdmmealrgpeaaakagiV 267 Verrucomicrobiu...

Feature 1         ## # #           #  #   #         #########       # # # 
NP_745914    329 IVSYTVYIKrr-eDITVVRAVCAALLpe-----rAVATFVQADVCRteLLVEIEAVA 379 Pseudomonas putida KT2440
YP_825014     98 IVRTTCYLRdierDYEAFNEERTAFFreqqldpmPASTGIQAILCRpeLLIEIEAIA 154 Solibacter usitatus Ellin6076
NP_813340    330 LELLRVYLKhe-eDAKIVKEDMDKLCp------dVPIVYLYADVCReeLLVEIEGIA 379 Bacteroides thetaiotaomicron VPI-5482
NP_811388    323 LGHMIVYLRdi-aDYAVVKSMYDKCFp------dTPKVFVHAPVCRpgWLIEMECMG 372 Bacteroides thetaiotaomicron VPI-5482
ZP_02013078  108 VSRAILYFPdi-sWMPRFEAHRAALGlp-----pIPGIYAHCDICRddLLFEIELDA 158 Opitutaceae bacterium TAV2
ACB75503     337 ITSATLFCKdr-aAWEAWERVTRLLQip-----aLPKVCVIADVCRhdLLVEMEAVA 387 Opitutus terrae PB90-1
YP_900492    331 VAQMIVYLRdp-sDSETVNAYLDENYr------nIPNIVTLAPVCRpgWLVEVECIA 380 Pelobacter propionicus DSM 2379
YP_001302022 313 LVKLRVYLKnk-sDYKEAERLMNTYGl------nIPISYMWADVCRdeLLIEIEGIA 362 Parabacteroides distasonis ATCC 8503
ZP_01054981  289 FDHFKVYFRhv-eDYECIRKILTQDWqi----aaEKLHFMNVDICRsdLLVELEGCI 340 Roseobacter sp. MED193
ZP_02929065  268 RRDFKCYLRha-eALPLIKDWLTEELgl----asHQATFLQADICRqeLDLEIEAVV 319 Verrucomicrobium spinosum DSM 4136
YP_825014     98 IVRTTCYLRdierDYEAFNEERTAFFreqqldpmPASTGIQAILCRpeLLIEIEAIA 154 Solibacter usitatus Ellin6076
NP_813340    330 LELLRVYLKhe-eDAKIVKEDMDKLCp------dVPIVYLYADVCReeLLVEIEGIA 379 Bacteroides thetaiotaomicron VPI-5482
NP_811388    323 LGHMIVYLRdi-aDYAVVKSMYDKCFp------dTPKVFVHAPVCRpgWLIEMECMG 372 Bacteroides thetaiotaomicron VPI-5482
ZP_02013078  108 VSRAILYFPdi-sWMPRFEAHRAALGlp-----pIPGIYAHCDICRddLLFEIELDA 158 Opitutaceae bacterium TAV2
ACB75503     337 ITSATLFCKdr-aAWEAWERVTRLLQip-----aLPKVCVIADVCRhdLLVEMEAVA 387 Opitutus terrae PB90-1
YP_900492    331 VAQMIVYLRdp-sDSETVNAYLDENYr------nIPNIVTLAPVCRpgWLVEVECIA 380 Pelobacter propionicus DSM 2379
YP_001302022 313 LVKLRVYLKnk-sDYKEAERLMNTYGl------nIPISYMWADVCRdeLLIEIEGIA 362 Parabacteroides distasonis ATCC 8503
ZP_01054981  289 FDHFKVYFRhv-eDYECIRKILTQDWqi----aaEKLHFMNVDICRsdLLVELEGCI 340 Roseobacter sp. MED193
ZP_02929065  268 RRDFKCYLRha-eALPLIKDWLTEELgl----asHQATFLQADICRqeLDLEIEAVV 319 Verrucomicrobium spinosum DSM 4136

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