Conserved Protein Domain Family
YjgF_YER057c_UK114_like_2

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cd06150: YjgF_YER057c_UK114_like_2 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100007
View PSSM: cd06150
Aligned: 70 rows
Threshold Bit Score: 107.238
Threshold Setting Gi: 126730626
Created: 3-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ##  # #       # # ##                                  # ## # #          #  #  
YP_257933     20 ARFSQAVIHn-----rTVYLAGQVSqlt-egdIRAQTQDVLQQIDALLARAGTDKGHLLSAQIWLKDmaDYPAMNLLWDA 93   Pseudomonas fl...
ZP_01445901   13 GRNSGTAFNg------MGWAVATTQvet--ddVHDQTASTLARIDEILAEMGTDKTRILNATIYVTDiaTKDEMDRAWCD 84   Roseovarius sp...
ZP_01984976   10 QGRNKSSAYk-----dLVWTVATSSdtt--lgIVEQTELTLRTIADNLRELGSDKTRIVSAQVYIANmkDKPLMDEVWCE 82   Vibrio harveyi...
NP_766894     15 PSKSAVTTYhmpggggLLWAVAVSPdrt--qdIRIQTLGALGVIDTYLKDAGLDRTRIVKAEIVVTDhdNKPAFDEAWAS 92   Bradyrhizobium...
YP_509596     11 IGKCSAAVHg-----gLAYIVANAPepg--egILDQTSGCLAELDRLLRSVGSDRTRVLQVTVYLSDiaDKPRMDSIWMP 83   Jannaschia sp....
NP_773829     10 PIMHRAVEAn-----gFVFFGGTIAddt-svsMGDQTRNILGKIAGYLKEAGTDKSRVVSASIFVTDlsKKKEMDAAWTE 83   Bradyrhizobium...
ZP_02083237   10 KHFARVTEYn-----gVLYFTGHIAagk-qptMTEQMVALTHRLDELLEQFGSDKNHILYAKINIHDwsMFDEFNAVWDA 83   Clostridium bo...
ZP_02119677   10 GLLHEVVAHg-----gVLYFAGIVAent-dldIAGQARDVLTQLDALLLAHGSDRQHVLQATAYLVDlgEKEGLNRAWKE 83   Methylobacteri...
NP_768102     10 GLLHEVVEHg-----gVLYIGGIVAedt-sldMSGQANDVLGQLSRLLKTLGSDLANVLQVTIFVTNlgEKAAFNAAWKA 83   Bradyrhizobium...
XP_001417056 860 LDCSPVVTWg-----rQVWLSGITCggvveptFTGQMRRVFDNLVRLLVMAGTDVAHLLQVKIHLKDirEMEAVCDIWDR 934  Ostreococcus l...
Feature 1         #         #########         # # #  
YP_257933     94 WLeg-----vqAPVRACVQAPMAkphYRIEVLVIAA 124  Pseudomonas fluorescens Pf-5
ZP_01445901   85 WIgdd---pqhWPQRACVETGLAa-gHRVEIVVVAA 116  Roseovarius sp. HTCC2601
ZP_01984976   83 WMgdn---sdhWPQRACLGVDLEg-dVLIEVTVTAV 114  Vibrio harveyi HY01
NP_766894     93 WMpa-----gyGPVRSFVQSVMPd-gDLIEIIITAA 122  Bradyrhizobium japonicum USDA 110
YP_509596     84 WIgae----enWPQRACVGADLDp-gYLIEIVATAV 114  Jannaschia sp. CCS1
NP_773829     84 FFgd------nLPTRATVGVADLggsALIEVVVTAL 113  Bradyrhizobium japonicum USDA 110
ZP_02083237   84 WFdp-----gcMPARTTAQSVLTd-gYLVEITLTAA 113  Clostridium bolteae ATCC BAA-613
ZP_02119677   84 FFga-----ahLPARATIGVQDLgrdVRLELVVTAA 114  Methylobacterium nodulans ORS 2060
NP_768102     84 HFae-----ahLPARAVVGVADLgsgVKLEMTAIAA 114  Bradyrhizobium japonicum USDA 110
XP_001417056 935 FFsdagitrehRPCRHITQAVLSnakLQVEMFAEAV 970  Ostreococcus lucimarinus CCE9901

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