Conserved Protein Domain Family
REX1_like

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cd06145: REX1_like 
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.
Statistics
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PSSM-Id: 99848
View PSSM: cd06145
Aligned: 70 rows
Threshold Bit Score: 169.974
Threshold Setting Gi: 159116309
Created: 11-Mar-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #### #                                                                       
Q8IX06       145 YALDCEMCYTTHG-----LELTRVTVVDaDMRVVYDTFVKPDNEIVDYNTRFSGVTeaDVAKTSITLPQVQAILLSFFSA 219 human
XP_001350101 465 YSIDCEMCETTNHq----RELTKITVVDaYMNIIYDSYVIPDNKITNYLTLYSGINesTLENVTTKLKDVQEHLKKFLNK 540 Plasmodium falc...
EDQ87178     270 FAVDCEMVRCGSR-----YALARISVVDqDEVTVMDEFVVPDEPVTDYVTRFSGITpeLLANATSRLADIQHRLAQLLRP 344 Monosiga brevic...
XP_001322300 194 IAIDCEMVETKLG-----SELARLSVTDfEGKPLLDQLFKPTNEILDYRTPFSGISeeTLANVTVTPDQALKILSKYASR 268 Trichomonas vag...
NP_201525    146 LSIDCEMVTCEDGs----QALVRVGAVDrDLKVVLDKFVKPDKPVIDYKTDITGVTaeDLERATLSVADIQKKLRRFLSV 221 thale cress
XP_001611809 275 FAIDCEMVTAGGV-----TALARITIVDsLLNTVFDALVKPEGDIQDYRTPYSGITaeSLEDVTIRLSDIQECLNMLIGP 349 Babesia bovis T2Bo
NP_001054092 143 LAIDCEMVLCHDGt----EALVRVCVVNsNLEVKLDELVNPLKAVADYRTSITGLSkkDLKGVTCSLVDVQKSLKKLLSK 218 Japanese rice
XP_001583874 194 IALDCEMIETTSEdgakhDELARLSVVNeKGEVIIDEYFKPIHPVSDLRTHVSGITqeHLDNAKLTSEDGVSALSAVADK 273 Trichomonas vag...
EDQ76512     170 VSLDCEMVTCEGDv----KELVRVCAVGsDYNTLVDELVVPNGKVTDYLTSITGVSekDLQRVTLSQAGVQKLVLDLLTP 245 Physcomitrella ...
CAO71915     125 LAVDCEMVLCEDGt----EGLVRVCVVDrNLQVKLNELVKPHKAVVDYRTEITGVSakDFDETTSSLVDIQRSMKKLLSH 200 wine grape
Feature 1              ## ###                                                           #    #   
Q8IX06       220 QTILIGHSLESDLLALKLIHSTVVDTAVLFPHYLGFpy--krSLRNLAADYLAQIIQds---------qNGHNSSEDANA 288 human
XP_001350101 541 KSILIGHSLENDLHALKIAHNYVIDTSIIYCNSGYYpk---pSLFQLSKKHLNIIMKr----------eNGHNSIDDAKI 607 Plasmodium falc...
EDQ87178     345 HDILVGHSLENDLGVLQRSHPHVIDTAVLLAREGRYk----qKLSMLTKKHLRYEIQna---------aDGHNSVEDALA 411 Monosiga brevic...
XP_001322300 269 KTIIVGHSLENDFRSLKLIHHRCIDTALLYNSETNGvk--kpSLFLLYKKYINKPFRan---------eSGHDSYEDARA 337 Trichomonas vag...
NP_201525    222 GTILVGHGLHNDLQVLRIDHARVIDTSYVFEFVDAPktq-rpSLNNLCKSVLGQEVRmd---------gAAHNCVHDAAA 291 thale cress
XP_001611809 350 DTILVGHSLDNDLKACEIAHFNVLDTALQYIAPRRHnk---pSLKSLVKQHIGIELVr----------dSGHDSYVDAST 416 Babesia bovis T2Bo
NP_001054092 219 GKILIGHSLSKDLHALKFDYSRVIDTAYIFKYANLPtta-saSLNSLCKSVLGYAVRee---------gEPHNCLKDAEA 288 Japanese rice
XP_001583874 274 ETIIVGHGLENDFKALLLFHTKVVDTSLIYNNERGVtyprkpKLSNLFQKYFKKEMRdq---------tKPHDSIDDARA 344 Trichomonas vag...
EDQ76512     246 GTILVGHSLHYDLRALQIDHKRVIDTSLLFRDPSWPpsy-spSLSNLCQIFDKIIGHqsilkykfreddKPHDCLDDSIV 324 Physcomitrella ...
CAO71915     201 GAVLVGHSLHNDLKALKLDHARVIDTAFIYKYENQPinr-rpSLNNLCKARVGFFLYiiadg--flfhlLGGEYFPFCSV 277 wine grape
Feature 1              
Q8IX06       289 CLQLVM 294 human
XP_001350101 608 SMFLAL 613 Plasmodium falciparum 3D7
EDQ87178     412 CLRLAK 417 Monosiga brevicollis MX1
XP_001322300 338 AMDLVN 343 Trichomonas vaginalis G3
NP_201525    292 AMKLVL 297 thale cress
XP_001611809 417 TMFLAM 422 Babesia bovis T2Bo
NP_001054092 289 AMNLVL 294 Japanese rice
XP_001583874 345 ALELSK 350 Trichomonas vaginalis G3
EDQ76512     325 PMRLVH 330 Physcomitrella patens subsp. patens
CAO71915     278 HFELLF 283 wine grape

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