1L3S,1QTM


Conserved Protein Domain Family
DNA_polA_I_Bacillus_like_exo

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cd06140: DNA_polA_I_Bacillus_like_exo 
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inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases
Bacillus stearothermophilus-like Polymerase I (Pol I), a subgroup of the family-A DNA polymerases, contains an inactive DnaQ-like 3'-5' exonuclease domain in the same polypeptide chain as the polymerase region. The exonuclease-like domain of these proteins possess the same fold as the Klenow fragment (KF) of Escherichia coli Pol I, but does not contain the four critical metal-binding residues necessary for activity. The function of this domain is unknown. It might act as a spacer between the polymerase and the 5'-3' exonuclease domains. Some members of this subgroup, such as those from Bacillus sphaericus and Thermus aquaticus, are thermostable DNA polymerases.
Statistics
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PSSM-Id: 176652
View PSSM: cd06140
Aligned: 97 rows
Threshold Bit Score: 70.7563
Threshold Setting Gi: 5822373
Created: 19-Mar-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1L3S_A        15 MLADKAALVVEVVeenyhdAPIVGIAVVNe-hGRFFLRPetal-------------adpqFVAWLGDetkkKSMFDSKRA 80  Geobacillus ste...
NP_975660    321 YEDSINYLYVESLeedyhkDKIIGIGISNn-kGNFYLDFknkaqqlsffedttlsstdslFEEFLNNsnlkKYTYDIKKT 399 Mycoplasma myco...
CAK98222     309 FNENNTTVYLELLdenyhtSEIIGFGIVNs-kGVFYFDYihak-------------hdklWHQFLNDnkyqKLTYHAKSL 374 Spiroplasma citri
AAL00966       3 AIKTPVAFGVEMLtdnyhtADLIGFYIGAp--DHWYVSDdvall------------aepvLKDWLEDashpKAVFGVKRT 68  Lactobacillus s...
ZP_02076447  305 LLVDGSVLYANLDaenyydATLYGFAIAHg-nNCEYISLedakn------------dtalLEYIHTDn--gKIVYDAKNV 369 Eubacterium dol...
YP_001728398 326 MMVDKVAVHIEMSgsnyhtADMIGFVIGNp-aTGYYASRdmsll------------qkpeLRAVIENgdikKNVFNVKAQ 392 Leuconostoc cit...
YP_806924    317 KLTEPLTFEIEMLednyhvAEQIGFFIGTk--EETYVSTdvtll------------tlpaVKRWLEDakrdLTVFDGKRN 382 Lactobacillus c...
ZP_01543994  345 EIKNYLTVYFQTDsdnyhtAKISAFVVGNe-nDGYFASRdlell-----------nssvvRKLFKGDl--pKYVFNAKEL 410 Oenococcus oeni...
YP_053824    318 FSCETNFLYIESIdenyhkGQILGLAICNe--KGFFYLNdiin--------------dleLEQFFLNdnfkKNTYDIKKT 381 Mesoplasma flor...
Q59156       311 SISQIRSKEIPLMf----vQGEKCFYLYDqesNTVFITSnk------------------lLIEEILKsdtvKIMYDLKNI 368 Anaerocellum th...
1L3S_A        81 AVALKWKGIELc--GVSFDLLLAAYLLDpa-----qgVDDVAAAAKMKQYeavrpdeavygkg--akravpdepvlaeHL 151 Geobacillus ste...
NP_975660    400 TYLLKNHKYNVlasNFDFDFMVACYSLNan------vISDLSNQIKLVDNmieletideifgkgvkknpdidldikskYI 473 Mycoplasma myco...
CAK98222     375 IVALARDNIFVq--NIEYDMMLAGYVYNsna---knsLDTYINLFEKKQIltdeffygkgvk----kqipadviklghFI 445 Spiroplasma citri
AAL00966      69 QVAANRLGVHLa--GVDFDLLLASYLLNttnn--sndLGTVANLHEYQNVqtdeavygkgak----ravptepallyqHL 140 Lactobacillus s...
ZP_02076447  370 YHAWHRNHIAFv--PVHRDVMLEAFLLDgmi----sdYDKLAEKYAFDCTlskedvfgkkgk-----pklvveedaaaYA 438 Eubacterium dol...
YP_001728398 393 LILFKRLGLTLk--GAQFDFLLVAYLLDttdn--dneMSTLAQRFDVYLTedeeiygkgaky-----avpddeelvlmHL 463 Leuconostoc cit...
YP_806924    383 IVAANRLGVKLp--DIAFDVLLASYLINpden--sndLGKIAEDHDYHDLprdediygkgak-----rqvpeddklfgQF 453 Lactobacillus c...
ZP_01543994  411 IVLLNRLGLQIn--NLDFDFLLVSYLLDttdn--dnqLATLANRFNVFLEsdaevygsgvkf-----kipennetlfsHM 481 Oenococcus oeni...
YP_053824    382 VTLLRNNNIKFsfsSFTYDAMIASYVLNpnvtsriqnLANIVETELFVEEdelfygkgvkq------nkeidtaskakFI 455 Mesoplasma flor...
Q59156       369 FHQLNLEDTNNi--KNCEDVMIASYVLDstrs--syeLETLFVSYLNTDIeav----------------------kkdKK 422 Anaerocellum th...
1L3S_A       152 VRKAAAIWELERPFLDELrrneQDRLLVELEQPLSSILAE 191 Geobacillus stearothermophilus
NP_975660    474 SKKAYLLKKYSDQLIEQLkqtnTYDLYLKIDHPLIEVLYD 513 Mycoplasma mycoides subsp. mycoides SC str. PG1
CAK98222     446 GEKASYIHKLRPKIIELLktnqQYDLYHNIELPIAFALAR 485 Spiroplasma citri
AAL00966     141 VQKAAAIYHLQPQLEEQLkehqQFDLFTDMELPLALVLAQ 180 Lactobacillus sakei
ZP_02076447  439 MQCAENLANIEQQLFDELeqkdMKELYDTIEMPVVEVLYA 478 Eubacterium dolichum DSM 3991
YP_001728398 464 AHKADALIQLEMPALSALqshqQTHLYTEIELPLAHVLAE 503 Leuconostoc citreum KM20
YP_806924    454 ARKSDALFALRPDLTGDLekqeQTDLFTDMEMPLSRVLAE 493 Lactobacillus casei ATCC 334
ZP_01543994  482 ANKASTISKLHDPSMKKLsdhqQAELYRQIELPLSKVLAS 521 Oenococcus oeni ATCC BAA-1163
YP_053824    456 VGKLELLYSTHKPIINLLkennQFNLYEKIELPLVEVLFN 495 Mesoplasma florum L1
Q59156       423 IVSVVLLKRLWDELLRLIdlnsCQFLYESIERPLIPVLYE 462 Anaerocellum thermophilum
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