1WLJ


Conserved Protein Domain Family
DEDDh_RNase

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cd06137: DEDDh_RNase 
Click on image for an interactive view with Cn3D
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonucleases PAN2, RNA exonuclease (REX)-1,-3, and -4, ISG20, and similar proteins
This group is composed of eukaryotic exoribonucleases that include PAN2, RNA exonuclease 1 (REX1 or Rex1p), REX3 (Rex3p), REX4 (or Rex4p), ISG20, and similar proteins. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. REX proteins are required for the processing and maturation of many RNA species, and ISG20 is an interferon-induced antiviral exonuclease with a strong preference for single-stranded RNA.
Statistics
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PSSM-Id: 99840
View PSSM: cd06137
Aligned: 17 rows
Threshold Bit Score: 166.302
Threshold Setting Gi: 82231230
Created: 9-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #### #                                                         #   #         
1WLJ_A          8 VAMDCEMVGLGph---------------reSGLARCSLVNv----HGAVLYDKFIRP--EGEITDYRTRVSGVTp----- 61   human
Q5F450        970 VGLDAEFVTLNeeeaelrsdgtkstikpsqMSVARITCVRgqgpnEGVPFIDDYIST--QEQVVDYLTQYSGIKpgd--- 1044 chicken
XP_001221192  197 VVLDCEMAGTSa-----------------gDYPIAVSVVDf---fTGAVLVDALVRPgaGVVVQDWRSGITGIGaa---- 252  Chaetomium gl...
XP_001548831  222 VTVDCEMAGTSgg----------------tGEVVMLCVIDy---iTGAVLLHRFVCP--REKITQMRSSIHGISkstl-d 279  Botryotinia f...
XP_001394342  310 VVIDCEMVQAEkg----------------rRVIAYLAAVDf---iTGEVLINSYVDP--QRRIFNWCTRYSGITlkam-k 367  Aspergillus n...
XP_383284      84 IALDCEMAGVRng----------------nDEIISICVIDf---fTGQVLINSLVEP--HEPILEWRTDIHGIGpati-a 141  Gibberella ze...
XP_001536163  365 VAIDCEMGQAAsg----------------dSELIRITLIDy---fSSAVLIDSLVYP--SVKMEHYRTRFSGVNrrdm-e 422  Ajellomyces c...
XP_001797910  398 VAIACSKVVLAdg----------------lQEVVKIAAVDv---vTCRILMNHLICNngTARVKNWRSDETGLYswddme 458  Phaeosphaeria...
XP_661961     369 VVLDCEMVGVVgpnn------------sevSEVVRLAAVDf---lSGEVLVNTFVEPaaDQRVINWRTRVSGVNksll-s 432  Aspergillus n...
XP_956344     150 VAIDCEMGVSSdf----------------eSELIRLSLIDy---fSGQVLIDRLVRP--NVPMQHMNTRYSGVTrqdl-q 207  Neurospora cr...
Feature 1                                                ## ###                                   
1WLJ_A         62 -qHMVGATPFA---------VARLEILQLLKG--KLVVGHDLKHDFQALKedmsgYTIYDTSTDRLLWREakldh----- 124  human
Q5F450       1045 ldAKISSKHLTt-------lKSTYLKLRFLIDvgVKFVGHGLQKDFRVINlmvpkDQVIDTVYLFHIPRKrm-------- 1109 chicken
XP_001221192  253 riADAGRAGSGdgeplagreGAREAVLRFVDGe-TVVVGQAVRFDLRALGiv--hGRVVDSAVLAAEASGrfggvagggg 329  Chaetomium gl...
XP_001548831  280 naNLQGQALSGw-------eGARSELWKYIDDh-TILVGHALQHDLDALRii--hPRIVDSGILSRNAVGirr------- 342  Botryotinia f...
XP_001394342  368 kaVANGDTLRGw-------mGARRALWDFIDSd-TVLIGHDIKHDLNCLGii--hPRIVDSTILTAEAVFrprwetq--- 434  Aspergillus n...
XP_383284     142 iaASQGQVLRGw-------eAARQELFKHINMq-TILVGQSLYHDLKVLRvs--hEKIFDTAIHTAEMVFgtdaa----- 206  Gibberella ze...
XP_001536163  423 aaKTAGSCIMGr-------dNARFAVWRYVGPe-TVVVGHSAHNDLESLRwi--hTAVVDTYIIEDLLEKkkncesk--- 489  Ajellomyces c...
XP_001797910  459 qaRKLGYKIFKgw------cAARSALSKFIDKd-TIILGHDLRSDLDCLRmi--hGRAVDIAKVAEKAAKgpls------ 523  Phaeosphaeria...
XP_661961     433 emKKQGQTVQGw-------eAARDLLWMFVDKq-TILIGHSLHNDLAVLGmv--hQRIVDSAILTRDAVAgake------ 496  Aspergillus n...
XP_956344     208 naIRNGTCIIGgl------eEARKEVWKFVGPq-TVVIGHSVRNDLSALRwi--hNRCVDSLVVEEGVRKkikakeeeee 278  Neurospora cr...
Feature 1                                                                                         
1WLJ_A        125 -----------------------------------------------------crrvSLRVLSERLLHKSIQns------ 145  human
Q5F450       1110 --------------------------------------------------------iSLRFLAWYFLDLKIQg------- 1126 chicken
XP_001221192  330 ------------------------------------------------vhrkikwwaGLEELCRELLGMRIRgg------ 355  Chaetomium gl...
XP_001548831  343 ------------------------------------------------------iqwGLQTLCSELLNIKIRnk------ 362  Botryotinia f...
XP_001394342  435 ---------------------------------------------------rfrrtwSLKTLSCVFLDRFIQgg------ 457  Aspergillus n...
XP_383284     207 ----------------------------------------------------fgrrwSLQSLCMDLLGLRIRqn------ 228  Gibberella ze...
XP_001536163  490 ---------------------------------------------------kdadktKDGKVAVETDKLLLLagepagne 518  Ajellomyces c...
XP_001797910  524 -----------------------------------------------------kpqlSLDSLCRDFNGVVLKsd------ 544  Phaeosphaeria...
XP_661961     497 ------------------------------------------------------dcaRVRKLAKTFFELDIQt------- 515  Aspergillus n...
XP_956344     279 kekekvrekqkeerlleislhcgpgmaeetrrmmeeeeikekekmkkmrgkrgedgmSLKALTKKKLGRVIQda------ 352  Neurospora cr...
Feature 1                #    #         
1WLJ_A        146 ----lLGHSSVEDARATMELYQ 163  human
Q5F450       1127 -----ETHDSIEDARTALQLYR 1143 chicken
XP_001221192  356 ---egQSHDSLEDVLATRELVL 374  Chaetomium globosum CBS 148.51
XP_001548831  363 ---kgGIHDCFEDVLATRDVVL 381  Botryotinia fuckeliana B05.10
XP_001394342  458 ----sNGHSALEDAVATKDVVM 475  Aspergillus niger CBS 513.88
XP_383284     229 ----sSTHEALEDTMAAREVAL 246  Gibberella zeae PH-1
XP_001536163  519 hehehELHEGEESEEMKGSTEQ 540  Ajellomyces capsulatus NAm1
XP_001797910  545 ---peYGRDMLMNAFAVREMGL 563  Phaeosphaeria nodorum SN15
XP_661961     516 ----gKGHDCLEDTFAAREVVL 533  Aspergillus nidulans FGSC A4
XP_956344     353 ---gkKGHDSVEDAVAARDLIH 371  Neurospora crassa OR74A

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