Conserved Protein Domain Family
RP_RTVL_H_like

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cd06095: RP_RTVL_H_like 
Retropepsin of the RTVL_H family of human endogenous retrovirus-like elements.
This family includes aspartate proteases from retroelements with LTR (long terminal repeats) including the RTVL_H family of human endogenous retrovirus-like elements. While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C-termini, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Retroviral aspartyl protease is synthesized as part of the POL polyprotein that contains an aspartyl protease, a reverse transcriptase, RNase H, and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133159
View PSSM: cd06095
Aligned: 12 rows
Threshold Bit Score: 92.3961
Threshold Setting Gi: 130407
Created: 15-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:inhibitor binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       # # #                            ###                              
AAA65999       39 VTLTVegKSIPCLIDTGATHSTLPsfqgpv-----------slapiTVVGIDGqa-skPLKTPPl----wCQLGQhsFMH 102  human
XP_792176      38 VMADVagVQIGCILDTGSEVSIIPsdlfhsqftallgcpeqleflvKITGISGte--vPVEGYVra---rVCIGDheAMV 112  purple urchin
AAK84933       13 VIING--IIINCLVDTGSDVTIIKeaifkkmkd-----vdlnrtatVLRGLGNas-tqPIGCFRa----lIKTDQveASH 80   fruit fly
AAM34208      707 LTILVdnQPVQALVDTGATFSTIQrqmmekd--------slstqseEVRGFSGetekwPLTKPLr-----VQVAGqtLLH 773  zebrafish
AAF65926      538 VTLKVegQPVEFLVDTGAEHSVLLqplgkl-----------kekksWVMGATGqr-qyPWTTRRt-----VDLGVgrVTH 600  domestic pig
XP_001379701  336 VTARIegTAFPLLVDTGAEHSVLKqtfgdv-----------tskfsLVQGVAGsr-pyPWTTERt-----VDLGShtVSH 398  gray short-ta...
AAF74214       18 VCLTIdgQEANCLLDTGVAFSVLFscprqr-----------ssravTIQGVLGq----PVTRYFsqp-lsCDWGTslFSH 81   human
P10394         51 HAKTG--VKLVFLLDTGADISILKensdkfsn-------iqitnkiNIQGIGQqkiqsRGQTFIe-----IQTGKyvIPH 116  fruit fly
AAP29639        4 MTVGG--KDIDFLVDTGAEHSVVTapvapl-----------skktiDIIGAMGvsakqAFCLPRt-----CTVGGhkVIH 65   Human endogen...
XP_001342872   59 VPILVegVPCVALVDTGSTVTVLRpdlvptna-------rldpttvLLRTVTGel--aPMKGKGev---eLTVGGktLQH 126  zebrafish
AAF81697       15 VKVGG--QIIDFLVDTGATHSVVQkpvgpm-----------skesvAIIGATG-----NIRNYPksegrlVDLGRglVTH 76   Fowlpox virus
YP_443922     780 VSCQIegVNHRFLVDTGCTYSAIKtmqpl------------smdsiQVVGVSGr----PETQLKtqp-llFRWGPstVRH 842  Atlantic salm...
Feature 1                        #       
AAA65999      103 SFLVIptc----plPLLGRNILT 121  human
XP_792176     113 GFLVGqkm----stDGKRQDFPI 131  purple urchin
AAK84933       81 NVLVVhdsk-fscdGIVGHDFIS 102  fruit fly
AAM34208      774 SFLCSanv----psALLGRDLLV 792  zebrafish
AAF65926      601 SFLVIpec----pvPLLGRDLLT 619  domestic pig
XP_001379701  399 SFLVVpns----paPLLGRDLLH 417  gray short-tailed opossum
AAF74214       82 AFLIMpes----ptPLLGRDILA 100  human
P10394        117 DFHLVdknfpipcdGIIGIDFIK 139  fruit fly
AAP29639       66 QFLYMpdc----plPLLGRDLLS 84   Human endogenous retrovirus HCML-ARV
XP_001342872  127 SVWVAtvq----dpCILGLDFLR 145  zebrafish
AAF81697       77 SFLVIpec----pdPLLGRDLLQ 95   Fowlpox virus
YP_443922     843 QFLYCpnc----piNLLGRDLLC 861  Atlantic salmon swim bladder sarcoma virus

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