Conserved Protein Domain Family
MUM1_like

?
cd06080: MUM1_like 
Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase V. It is highly expressed in several types of human cancers. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
?
PSSM-Id: 99903
View PSSM: cd06080
Aligned: 7 rows
Threshold Bit Score: 90.1876
Threshold Setting Gi: 145543276
Created: 8-Feb-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  #  #                        #        # #                           
Q5H9M0        390 FETGMIVWFKYQKYPFWPAVIKSIrrk-------erKASVLFVEan-mnSEKKGIRVNFRRLKKFDckek-qmlvDKARE 460  human
XP_423267     155 IDKGILVWCKWQRYPYWPAVVKNVkrk-------hrKANVLFIEgd-tsDKKKSFSVSLRNLKHFDceek-qdliDQAKK 225  chicken
EDL01011      380 IERGTLVWFKFQDLPFWPAVVKSVsen-------dkMARVLLIEgn-mqFERRGIRVPLRKLKHLDcgek-vslvRRASR 450  house mouse
XP_001424025    3 FNKNDVFWGKIQGYPYWPCTIAYDqpd-------kqKCRVFFFGdn--qQGELKYQDLKPFEEHFEhycsqakknNNLKI 73   Paramecium te...
XP_001457324   37 FEINEVVWAKVLGYPWWPAQISSIsngkt---gtnqSYRVNFLAdg--tHADCRLEKVKKWNDRPTqt-----etKKLKE 106  Paramecium te...
XP_001439860    9 YTKDEIVWAKIRGYPWWPGIIAEVikekq--sseptKYLVNFIGdnsqsSTLPFQSLAKYQEKYEEivqk--iktKQHKD 84   Paramecium te...
XP_001024832   10 YSKNDLVYAKIRGYPWWPGIIGEIkmkpgengekkyELLVNFIGdh-shSMVNEDKLQKFYVKEIDf-------kNKKRK 81   Tetrahymena t...
Feature 1                  
Q5H9M0        461 DYSESIDWC 469  human
XP_423267     226 DYCQEIEWC 234  chicken
EDL01011      451 LYAQGINWC 459  house mouse
XP_001424025   74 SIEQAINKE 82   Paramecium tetraurelia strain d4-2
XP_001457324  107 AIELANQIQ 115  Paramecium tetraurelia strain d4-2
XP_001439860   85 SVTAADQIL 93   Paramecium tetraurelia strain d4-2
XP_001024832   82 KLMQSIQIA 90   Tetrahymena thermophila SB210

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap