1T77,1MI1


Conserved Protein Domain Family
Beach

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cd06071: Beach 
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BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Statistics
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PSSM-Id: 100117
View PSSM: cd06071
Aligned: 69 rows
Threshold Bit Score: 219.422
Threshold Setting Gi: 145344695
Created: 26-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1T77_A        137 TQRWQHReiSNFEYLMFLNTIaGRSYNDLNQYPVFPWVITnyeseel---------------------------dltlpt 189  human
CAG08933      166 VLDWVHGrvSNFCYLMELNRLaGRRQGDPNYHPVLPWVVDftv----------------------------------pfg 211  spotted green...
EDM05212      345 VLDWVHGrvSNFYYLMQLNRLaGRRQGDPNYHPVLPWVVDftt----------------------------------pyg 390  Norway rat
XP_001633336  366 VDMWVRDeiTNFDYLMALNYHsGRRLGDPNYHPLFPWVVDfte----------------------------------ecg 411  starlet sea a...
XP_647543     475 MNKWINGelSNFNYLMILNHLaHRHIGDPMNHPVLPWVIDfttspinidndndsrddvdnssssnnnnnnnnedqsgktv 554  Dictyostelium...
XP_001197020  384 MQKWAMGqlTNFDYLMILNRLaNRQMGNPNHHPIMPWVMDftq----------------------------------pdg 429  purple urchin
XP_001744975  374 VEAWLLGgiSNFDYLMALNSHaGRRLNDPNHHPIFPWITDfsgs--------------------------------slgd 421  Monosiga brev...
NP_609535     345 TEMWCNGqlSNFDYLTILNNAcGRSLTNAAYHHIMPWVTDfsgr---------------------------------ggg 391  fruit fly
ABY48800      236 TSNWANRkwENYQYLTYLNDItGRVRGEVHNHPIFPWVCDfse----------------------------------eng 281  nematode
NP_197354     348 FDKWWKGelSNFEYLLVLNKLaGRRWGDHTFHPVMPWVIDfskkpe-----------------------------ndsds 398  thale cress
1T77_A        190 NFRDLSKPIGALnpkraaffaery------------------------------esweddqvpkfHYGTHYSTASFVLAW 239  human
CAG08933      212 KFRDLRRSKFRLnkgdkqldftyemtkealaaavgng----vggsgvgdlsgsvgtggggqpehlHVPHHISDVLSDITY 287  spotted green...
EDM05212      391 RFRDLRKSKFRLnkgdkqldftyemtr------------------------qafvaggagsgeplHVPHHISDVLSDITY 446  Norway rat
XP_001633336  412 GFRDLSKTKFRLnkgdhqldmmykq----------------------------swfesheggnseTVPHHVSDVLSEITY 463  starlet sea a...
XP_647543     555 GWRDLTKTKYRLnkgdeqldfqffntgnsttlgddsmgggigsigstggitnssnngggggsgnsGKAHHISDILSELTY 634  Dictyostelium...
XP_001197020  430 NYRDFSKSKYRLnkgdnqldftyesal-----------------------qmqamneedgsnlagQVPHHISDVLSEITY 486  purple urchin
XP_001744975  422 SWRDLTQSKYRLnkgdaql----------------------------------------dlawtgPDPHHVADILSELSY 461  Monosiga brev...
NP_609535     392 AWRDLTKSKYRLnkgdvhldlmyahas------------------------qhgsadgsyqaigdQAPHHVSDFLSEITY 447  fruit fly
ABY48800      282 GFRQLNRTKYRLckgddql----------------------------------------remysrEPSHHVPELLSDIGY 321  nematode
NP_197354     399 GWRDLRKSKWRLakgdeql---------------------------------------dftystfEFPHHVSDECLSELA 439  thale cress
1T77_A        240 LLRIEPfttyflnLQGGKFDhaDRTFSSISRAWRNSqrd-------------------------tsDIKELIPEFYYLPE 294  human
CAG08933      288 FVYKARqtp--ksVLCSHVRs-QWEPNEYPASMERMqs---------------------------wTPDECIPEFYTDPS 337  spotted green...
EDM05212      447 YVYKARrtp--rsVLCGHVRa-QWEPHEYPATMERMqt---------------------------wTPDECIPEFYTDPS 496  Norway rat
XP_001633336  464 HAYLARrtp--vsVLCEHLRs-NWVPNEYPASMKRLfe---------------------------wTPDECIPQFFTDPS 513  starlet sea a...
XP_647543     635 YSYLARrts--vpLLRRFVRt-NYEPNEYPATMERLyr---------------------------wTPDECIPEFFTDST 684  Dictyostelium...
XP_001197020  487 YIYKARctp--ksLLQTHVRs-VWVPNEYPASMQRLqg---------------------------wTPDECIPEFFSDAS 536  purple urchin
XP_001744975  462 FVLKARvtp--kdILCEHVRs-RWVPEEYPSSMHRHtqtlpappdtphlslprahlcftqermymvSPDECIPEFYTDPS 538  Monosiga brev...
NP_609535     448 FVYMARrtp--qsILCAHVRp-IWVPAEYPVSIQRLqe---------------------------wTPDECIPEFYSDPM 497  fruit fly
ABY48800      322 MVYRARvep--kdNLCRHVRr-KWVPEEYPSTMSRMyq---------------------------wTPDECIPEFYDDPS 371  nematode
NP_197354     440 VCSYKArrl-plsVLRKAVRs-VYEPNEYPSDMQRLyd---------------------------wTPDECIPEFYCDPR 490  thale cress
1T77_A        295 MFVNFnnynlgvmddgtvvsDVELPPWAKts--eeFVHINRLALESefvscqLHQWIDLIFGYKQqgpeavraLNVFYYl 372  human
CAG08933      338 IFRSIhpd----------mpDLDVPSWCKsy--edFIEVHRRLLESrevsqhLHYWIDLTFGYKLsgkeaikaKNVCLHl 405  spotted green...
EDM05212      497 IFCSIhpd----------mpDLDVPAWCSsn--qeFVTAHRALLESwevsqdLHHWIDLTFGYKLqgkeavkeKNVCLHl 564  Norway rat
XP_001633336  514 IFSSIhdd----------lpDLALPPWTPtp--tdFISWHRSALESdevsreLHNWIDLTFGYKLsgkaaikaKNVCLDl 581  starlet sea a...
XP_647543     685 IFKSIhsd----------mpDLQLPDWVPnqstqeFIKIHMNALESdhvskqLHSWIDLTFGYLLsgeeaikaKNLALMd 754  Dictyostelium...
XP_001197020  537 IFKSThdd----------lpDLEVPSWCKgp--edFVQRHRAVLESpyvserLHRWIDLTFGCKLsgsaavkaKNVVLCv 604  purple urchin
XP_001744975  539 MFRSIhad----------lpDLHLPAWADsp--edFIAQHREALESdyvtehLHTWIDLTFGYLLtgeaavkaKNVPYDl 606  Monosiga brev...
NP_609535     498 IFKSIhed----------lpDLELPAWATcp--edFICKHREALESqyvserLHHWIDLNFGYKLsgkaavksKNVCLTl 565  fruit fly
ABY48800      372 IFNSChpd----------maDLRFPEFVSsp--qeFIEWHRKMLEHeevsmnLHRWIDLVFGFNLaidnsknaLNLHLCf 439  nematode
NP_197354     491 IFCSLhps----------msDLAVPPWASsp--deFIRLHRDALESphvsslIHHWIDITFGYKMsghaaitaKNVMLSs 558  thale cress
1T77_A        373 tyegavnlnsitdpvlreaveaqirsFGQTPSQLLIEPHPPR 414  human
CAG08933      406 vdn-------------------htnlTTYGVVQLFDQPHPPR 428  spotted green pufferfish
EDM05212      565 vda-------------------hthlTSYGVVQLFDQPHPQR 587  Norway rat
XP_001633336  582 vsk-------------------sqsvSNFGVVQLFTQPHPPQ 604  starlet sea anemone
XP_647543     755 tt----------------------ipRNNGIVQLFNHPHPKK 774  Dictyostelium discoideum AX4
XP_001197020  605 vdq-------------------htlpANNGVVQLFNVPHPKR 627  purple urchin
XP_001744975  607 vgk-------------------rnvlKNSGVVQIFQAPHPAK 629  Monosiga brevicollis MX1
NP_609535     566 vdq-------------------hrnlSQRGIVQLFASAHPPR 588  fruit fly
ABY48800      440 vekn------------------rrglRTTGMVQLFNRPHPIR 463  nematode
NP_197354     559 sep--------------------tvpRSVGRRQLFFRPHPVR 580  thale cress
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