Conserved Protein Domain Family
H2MP_NAD-link-bidir
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cd06066: H2MP_NAD-link-bidir 
Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit assembly. These bidirectional hydrogenases are heteropentamers encoded by the hox (hydrogen oxidation) genes, in which complex HoxEFU shows the diaphorase activity, and HoxYH constitutes the NiFe-hydrogenase.
Links
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Statistics
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PSSM-Id: 99876
Aligned: 28 rows
Threshold Bit Score: -1
Created: 10-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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nickel binding
Feature 1:nickel binding site [ion binding site]
Evidence:
  • Comment:based on sequence similarity to HybD structure, 1CFZ_A
  • Comment:Replacement of the homologous metal binding residues in HycI (hydrogenase 3 processing endopeptidase) by site-directed mutagenesis suggest a role in catalysis.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                #                  
YP_525084  12 LVFGWGNLSRGDDALGPLCIERLRalaa---pataVDYLDDYQlQIEHALDLVgrqRVLFVDASlsc-paPFELTQLQAA 87  Rhodoferax ferrire...
YP_112652   5 LVFGYGNPSRGDDALGPLFLEALQirlas-spgvdIEFLQDFQlQIEHALDLAgrdRVLFVDAHvgc-ppPFRFERLVPQ 82  Methylococcus caps...
YP_412365  25 LVFGYGNPSRGDDALGPLLIERLEald-----lpnVELLTDFQlQIEHALDLQsreRVLFVDTSisc-vpPYAFSRLLAR 98  Nitrosospira multi...
AAD38066   11 VVFAWGNESRGDDALGPPAGPGIAlag-----wshITLIEDVQlQVEHALDLVgqdLALFYDAGmgt-paPFAFVQAVPR 84  Rhodobacter capsul...
YP_284209   6 VVFAVGNPSRGDDAIGPELCGRLEkwldheglgerVELIEDFQlQIEHALDLQgrqLALFIDAGant-paPYTFQRIVPA 84  Dechloromonas arom...
YP_942645  10 NLFTWGNPSRGDDAIGPVLHEFIKqficr-fdlghIQLVEDFQlQPEHVCDITdnaCVVFIDASyqg-esPFQIQPVSAK 87  Psychromonas ingra...
YP_932920   6 VVIAVGNDARGDDALGPLLLDRVVkag-----fpgVRAQLEFQlQVEHALDISgagLVLFIDAAhgl-htPYELSELEPA 79  Azoarcus sp. BH72
AAB57893   21 LIYGIGNVGRQDDGLGWAFIDWIEeegl----cpkAEILRHYQlHLEDAELIShkkRVLFVDATkdasvtSFALERAEPR 96  Rhodococcus opacus
NP_942731  21 LIYGIGNVGRQDDGLGWAFIDRLEaesl----csgAEVQRHYQlHLEDADLISrkrKVLFIDATkdasvaSFSLERAEPR 96  Ralstonia eutropha...
YP_431450  11 LVIGYGNPGRQDDGLGPACADRIAeln-----lsgVTVETNYQlTVEDALELSryqQVVFIDASlrg-gkPFFLQQIEAD 84  Hahella chejuensis...
YP_112652   5 LVFGYGNPSRGDDALGPLFLEALQirlas-spgvdIEFLQDFQlQIEHALDLAgrdRVLFVDAHvgc-ppPFRFERLVPQ 82  Methylococcus caps...
YP_412365  25 LVFGYGNPSRGDDALGPLLIERLEald-----lpnVELLTDFQlQIEHALDLQsreRVLFVDTSisc-vpPYAFSRLLAR 98  Nitrosospira multi...
AAD38066   11 VVFAWGNESRGDDALGPPAGPGIAlag-----wshITLIEDVQlQVEHALDLVgqdLALFYDAGmgt-paPFAFVQAVPR 84  Rhodobacter capsul...
YP_284209   6 VVFAVGNPSRGDDAIGPELCGRLEkwldheglgerVELIEDFQlQIEHALDLQgrqLALFIDAGant-paPYTFQRIVPA 84  Dechloromonas arom...
YP_942645  10 NLFTWGNPSRGDDAIGPVLHEFIKqficr-fdlghIQLVEDFQlQPEHVCDITdnaCVVFIDASyqg-esPFQIQPVSAK 87  Psychromonas ingra...
YP_932920   6 VVIAVGNDARGDDALGPLLLDRVVkag-----fpgVRAQLEFQlQVEHALDISgagLVLFIDAAhgl-htPYELSELEPA 79  Azoarcus sp. BH72
AAB57893   21 LIYGIGNVGRQDDGLGWAFIDWIEeegl----cpkAEILRHYQlHLEDAELIShkkRVLFVDATkdasvtSFALERAEPR 96  Rhodococcus opacus
NP_942731  21 LIYGIGNVGRQDDGLGWAFIDRLEaesl----csgAEVQRHYQlHLEDADLISrkrKVLFIDATkdasvaSFSLERAEPR 96  Ralstonia eutropha...
YP_431450  11 LVIGYGNPGRQDDGLGPACADRIAeln-----lsgVTVETNYQlTVEDALELSryqQVVFIDASlrg-gkPFFLQQIEAD 84  Hahella chejuensis...

Feature 1             #                                                          
YP_525084  88 RDISFTT-HALSPQALMQVFFDLrgeapPSCTLLAIRGECFELGa-pPSPAALAHLAAALAWATDWL 152 Rhodoferax ferrireducens T118
YP_112652  83 RDGSYTT-HAVSPQALLEVYRRInrdepPPAYLLSIRGERFDLGd-aLSRSAESNLESALRFAEVLI 147 Methylococcus capsulatus str. Bath
YP_412365  99 KDVSFTS-HVMSPIALLYAYLNLyg-ppPPAYLIEIRGDCFELGe-pLGPRAAANLDASFQLARRLC 162 Nitrosospira multiformis ATCC 2...
AAD38066   85 RFLGPSTsLGIGPEGVLEAYRQVmhdepPPAFVLCLRGESFALEe-gLSAAARAHLAQAWGFLIPLL 150 Rhodobacter capsulatus
YP_284209  85 TGNAYTT-HELPPEAVLQVYVQTenaepPPAFVLCVRGEQFELGe-gFCVAAALHLDAAFDLLTRLL 149 Dechloromonas aromatica RCB
YP_942645  88 NELGYTT-HALSPAALMAIYAQTqnkpcPPAFLFSVRGYSFELGa-pLSKQAQENITLATQFLKKLL 152 Psychromonas ingrahamii 37
YP_932920  80 RATPAFS-HALAPAAVLAVLEQLeg-haPPAFLLRVRGEQFGLGd-sLSPLAEAALPLAWELLATLL 143 Azoarcus sp. BH72
AAB57893   97 MDFSFTS-HAISIPAIMATCQQCfq-rlPDVYVLPIKGYEWELEl-gLTQRARQNLNAATARLSIRT 160 Rhodococcus opacus
NP_942731  97 MDFSFTS-HAISIPSIMATCQRCfq-clPEVYVLAIRGYEWELRm-gLTPQARHNLDDAIAHFSMRA 160 Ralstonia eutropha H16
YP_431450  85 DERQMGS-HVLSPQAVVTLSRTLfd-anTQAFLMGIRGYAFDRFeeaLSPEAQLNLNQAFDYLASWL 149 Hahella chejuensis KCTC 2396
YP_112652  83 RDGSYTT-HAVSPQALLEVYRRInrdepPPAYLLSIRGERFDLGd-aLSRSAESNLESALRFAEVLI 147 Methylococcus capsulatus str. Bath
YP_412365  99 KDVSFTS-HVMSPIALLYAYLNLyg-ppPPAYLIEIRGDCFELGe-pLGPRAAANLDASFQLARRLC 162 Nitrosospira multiformis ATCC 2...
AAD38066   85 RFLGPSTsLGIGPEGVLEAYRQVmhdepPPAFVLCLRGESFALEe-gLSAAARAHLAQAWGFLIPLL 150 Rhodobacter capsulatus
YP_284209  85 TGNAYTT-HELPPEAVLQVYVQTenaepPPAFVLCVRGEQFELGe-gFCVAAALHLDAAFDLLTRLL 149 Dechloromonas aromatica RCB
YP_942645  88 NELGYTT-HALSPAALMAIYAQTqnkpcPPAFLFSVRGYSFELGa-pLSKQAQENITLATQFLKKLL 152 Psychromonas ingrahamii 37
YP_932920  80 RATPAFS-HALAPAAVLAVLEQLeg-haPPAFLLRVRGEQFGLGd-sLSPLAEAALPLAWELLATLL 143 Azoarcus sp. BH72
AAB57893   97 MDFSFTS-HAISIPAIMATCQQCfq-rlPDVYVLPIKGYEWELEl-gLTQRARQNLNAATARLSIRT 160 Rhodococcus opacus
NP_942731  97 MDFSFTS-HAISIPSIMATCQRCfq-clPEVYVLAIRGYEWELRm-gLTPQARHNLDDAIAHFSMRA 160 Ralstonia eutropha H16
YP_431450  85 DERQMGS-HVLSPQAVVTLSRTLfd-anTQAFLMGIRGYAFDRFeeaLSPEAQLNLNQAFDYLASWL 149 Hahella chejuensis KCTC 2396

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