Conserved Protein Domain Family
H2MP_Cyano-H2up

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cd06063: H2MP_Cyano-H2up 
This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found exclusively in the N2-fixing strains and are encoded by hup (hydrogen uptake) genes. These uptake hydrogenases are heterodimers with a large (hupL) and small subunit (hupS) and catalyze the consumption of the H2 produced during N2 fixation. Sequence similarity shows that the putative metal-binding resides are well conserved in this group of hydrogen maturation proteases. This group also includes such proteins as the hydrogenase III from Aquifex aeolicus.
Statistics
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PSSM-Id: 99874
View PSSM: cd06063
Aligned: 7 rows
Threshold Bit Score: 226.507
Threshold Setting Gi: 98152884
Created: 21-Dec-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
nickel binding
Feature 1:nickel binding site [ion binding site]
Evidence:
  • Comment:based on sequence similarity to HybD structure, 1CFZ_A
  • Comment:Replacement of the homologous metal binding residues in HycI (hydrogenase 3 processing endopeptidase) by site-directed mutagenesis suggest a role in catalysis.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #                                               #                  
AAZ73687    2 LTIIGCGNLNRCDDAVGVIIAQRLQqyliqnphpnVRIFDCGTAGMEVMFQARGSkQLIILDASsTGSePGAVFEVPgSE 81  Lyngbya majuscula ...
YP_611133   9 TAIIGCGNINRGDDGAGPAVIARLAaedl---psdVELLDAGTDGMAVMYRARGAqQLIVIDARePEGkPGAIYEVPgDV 85  Sphingopyxis alask...
NP_485466   2 LTIIGCGNLNRSDDAVGVIIAQRLQkylaenphphVQVYDCGTAGMEVMFQARGSkQLVIIDASsTGSePGAVFKVPgEE 81  Nostoc sp. PCC 7120
YP_480186  33 VAVIGCGNLLRGDDGVGPILVRRLAetgv---pagVRLVDGGTAGMDTAFAMRGArRVVVVDASrTGAePGTVFEVPgAQ 109 Frankia sp. CcI3
BAF73673    4 VVIVGCGNPIRGDDGVGPRLIRYLWergl---pphIKLVDGGTSGIDVVFHMEGAdEVVFVDACcTGEkPGTVFCVPhEE 80  Hydrogenobacter th...
ABX56595    3 TTIIGFGNMLRKDDGLGPELIRRLMalnp---plpVKLIDYGTAGFSFLNELETEnRLIIIDAVsSGSaPGSLFVLEkER 79  Verrucomicrobiae b...
AAS72556    2 LTIIGCGNINRSDDAVGVVVVQRFQqflkehpcsdVRIYDCGTAGMEVMFRARGSkELIIVDACmTGSePGMIFKIPgSV 81  Gloeothece sp. PCC...
Feature 1                   #                                                         
AAZ73687   82 LEQLPEPSy---NLHDFRWDHALAAGRRIFqEDFPqAVSVYLIEANSLefGWELSSPVEQAAEKVFQSIIQI 150 Lyngbya majuscula CCAP 1446/4
YP_611133  86 LAAEPVHGv---GLHAFRWDNALFVGRKIFgDDFPsDVQVYLIEAQTLdyATELSGPVVAAVEKVAAKIAAR 154 Sphingopyxis alaskensis RB...
NP_485466  82 LAALPEPSy---NLHDFRWDHALAAGRKIFpDDFPqDVTVYLIEAANLdfGLELSPVVQQSADLVVEKIVEI 150 Nostoc sp. PCC 7120
YP_480186 110 LENLPLDAp---HPHAFRWDQALAFGRWLLgDGYPdDVVVYLIEAGGVepGADLSPAVRRAMEQVRDMIISG 178 Frankia sp. CcI3
BAF73673   81 VEELPSSEe--aNLHSIKWYHAVAIARHLLnGNYPkSIKVYLIEGKSFgiGEVLSEEVESAMKRLAERIIKE 150 Hydrogenobacter thermophilus
ABX56595   80 LELVLKEReeypNLHTFRWNDALRWGRWFLkGNFPrNVRVYLVEVKETgyGIGLSEPVKEAVERLVALFKKE 151 Verrucomicrobiae bacterium V4
AAS72556   82 LEVLPEQSy---SLHDFRWDHTLAAGRKIFrNDFPkEVTVYLIEVESLdfGLELSPSVKDAAEQVLEMLQDQ 150 Gloeothece sp. PCC 6909

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