Conserved Protein Domain Family

cd06008: NF-X1-zinc-finger 
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.
PSSM-Id: 100116
View PSSM: cd06008
Aligned: 166 rows
Threshold Bit Score: 39.2508
Threshold Setting Gi: 49654083
Created: 27-Feb-2008
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q12986        480 CSNPCEniLNCGqHQCaelCHGGq-Cq-PC--QIILnqVCYCGStsRDVLCGT 528  human
XP_315372     250 CARKCKrkLACGiHECgaqCHDAgqCp-PCq-NRSKq-PCLCGAqtKEVNCHE 299  Anopheles gambiae str. PEST
EDS37721      291 CLKTCKlkRNCGiHECggvCHAAseCp-PCt-SRSKq-KCACGSrtKEVNCSE 340  southern house mosquito
NP_647879     239 CQQTCKelLACGkHKCnqvCHQPgkCp-PCt-SKSLq-PCECQResKMVNCSD 288  fruit fly
EDP54169     1394 CGEPCD--VQCGhSKCtkkCQEP--Ct-PCaeERCFs-RCPHSA--CTMPCAA 1438 Aspergillus fumigatus A1163
AAW22876      223 CNGVCKkmLDCNtHRCneiCHADd-Cp-PCk-AKGMf-NCQCGKveMKRECFD 271  tomato
XP_001671788  673 CGVICQkpLKCGvHVCqrtCHGDe-CekEG--EQCTk-KCEAIRerCEHPCGL 721  Caenorhabditis briggsae AF16
NP_001071774  738 CGAPCSkmLACG-HKCqrpCHKGa-CceDG--EPCKq-PCSIMRveCIHPCAN 785  Ciona intestinalis
XP_001601161  999 CGLPCNkpISCGrHKCiqmCHSGp-CekPG--QVCTq-PCTVPRelCGHICAA 1047 jewel wasp
XP_001653734  701 CGLACAkpLPCGrHKCikpCHENe-CyvEG--EICKq-FCTTIRsnCTHQCKA 749  yellow fever mosquito
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