1OEY,1IP9,2NPT,1WI0,1Q1O,1WMH,2BKF,2NPT,2O2V,1OEY,2DYB,1WMH


Conserved Protein Domain Family
PB1

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cd05992: PB1 
Click on image for an interactive view with Cn3D
The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as a noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99716
View PSSM: cd05992
Aligned: 153 rows
Threshold Bit Score: 40.3389
Threshold Setting Gi: 156115398
Created: 25-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction surface [polypeptide binding site]
Evidence:
  • Structure:1OEY; Human PB1 domain of p67 and p40 form an asymmetric heterodimer
    View structure with Cn3D
  • Comment:Despite overall structure similarity between p67 and p40 PB1 domains, they formed an asymmetric heterodimer using different surface from each protein. p40 represents type I of PB1 domain, and p67 - type II of PB1 domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                   #                                        
1OEY_A          6 YTLKVHYk-----YTVVXktq----pglPYSQVRDXVSKKLElrl---------ehTKLSYRPRdsneLVPLSE-DSXKD 66   human
P40995        773 TNVKIRLrl--heVSLVLvva----hdiTFDELLAKVEHKIKlcgilk--qavpfrVRLKYVDEdg-dFITITSdEDVLM 843  fission yeast
ABH09721      766 TQLKAKVnf--ddNYVTLvia----sniLFRSLTDRVDAKLArftnrs---ignrsVRLRYKDEdg-dFITIDSdEAVQL 835  Penicillium m...
ABJ97446     1011 VLVKLRFg-----NDQFIlgvs---qgiDFITLYQKIHKKIRlcsssnrptnehdkLQIRYVDNdg-dEIQVKFdSDVEL 1081 Cryptococcus ...
1OEY_J          6 NWLRVYYyedtisTIKDIaveedlsstpLLKDLLELTRREFQre-----------dIALNYRDAeg-dLVRLLSdEDVAL 73   human
2DYB_A        240 NWLRCYYyedtisTIKDIaveedlsstpLLKDLLELTRREFQre-----------dIALNYRDAeg-dLVRLLSdEDVAL 307  human
NP_001034361  238 NKIRCYYydetvsTIRDIsveenlssipLFKDLMELIKQEFDqh-----------dIVLNYRDLdg-dLIRLLSdQDVEL 305  chicken
NP_001076354  250 SCLHCYFlqpegiETRDIcvqedlsiqpSYEDLLSRMRDVFHvd-----------dIALNYRDAeg-dLIRILDdEDVVL 317  zebrafish
CAL50176      251 FTFDVTCe----gEVKSIklp----vqlRYSDLVNAIKSEFGie----------kyVAVKYRDFdg-dFVTITSrMDLRT 311  Ostreococcus ...
XP_001415841  193 FTFDVTYe----gEVKSIqlp----vslKYSDLTDSIKKEFDik----------thVAVKYKDFdn-dFITITSrMDLRS 253  Ostreococcus ...
Feature 1                                       
1OEY_A         67 AWGqvk---------------nyCLTLWCE 81   human
P40995        844 AFEtctfelmdp--vhnkgmdtvSLHVVVY 871  fission yeast
ABH09721      836 AFMewrdqhqd----slaqgqvgEIQLFCQ 861  Penicillium marneffei
ABJ97446     1082 MFEdard-------------qagHINLIAR 1098 Cryptococcus neoformans var. grubii
1OEY_J         74 XVRqarglp--------sqkrlfPWKLHIT 95   human
2DYB_A        308 MVRqarglp--------sqkrlfPWKLHIT 329  human
NP_001034361  306 MVSqsrkrs--------sekhffPWKLHIT 327  chicken
NP_001076354  318 MVQeskrmesk----vkrpviqfPWELLVT 343  zebrafish
CAL50176      312 ALTnfaavaereakeknekpesaIPVIHVT 341  Ostreococcus tauri
XP_001415841  254 ALTnfaamaehrakesgekaetsIPVIQVT 283  Ostreococcus lucimarinus CCE9901

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