1KB5,1BWM,1FYT,1J8H,1KTK,1MI5,1NFD,1OGA,1ZGL,2ESV,2EYR


Conserved Protein Domain Family
IgV_TCR_beta

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cd05899: IgV_TCR_beta 
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain
The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.
Statistics
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PSSM-Id: 409480
View PSSM: cd05899
Aligned: 22 rows
Threshold Bit Score: 133.176
Threshold Setting Gi: 3114395
Created: 26-Dec-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD; human alpha/beta T-cell receptor (TCR) beta chain IgV domain forms interface with alpha chain IgV domain, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Human alpha/beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       # #       #  #                                
1KB5_B      4 LEQNPr-WRLVPRGQAVNLRCILKns-qYPWMSWYQQDLQkqLQWLFTLRSp-gDKEVKSlpg--adYLATRVtd-tELR 77  house mouse
1KTK_E      4 VSQHPs-RVIAKSGTSVKIECRSLdf-qATTMFWYRQFPKqsLMLMATSAEgskATYEQGvek--dkFLINHAsl-tLST 78  human
1NFD_B      4 VVQSPr-HIIKEKGGRSVLTCIPIs--gHSNVVWYQQTLGkeLKFLIQHYEk-vERDKGFlp---srFSVQQFdd-yHSE 75  Mus musculus
P01734     23 VIQTPr-YLVKGQGQKAKMRCIPEk--gHPVVFWYQQNKNneFKFLINFQNq-eVLQQIDmte--krFSAECPsn-sPCS 95  house mouse
P01735     23 ITQSP--RYLILGRANKSLECEQHl--gHNAMYWYKQSAEkpPELMFLYNLk-qLIRNETvp---srFIPECPds-sKLL 93  house mouse
AAC03369   17 ITQEPr-SIITRAGSAALMRCEQKts-dYEWMFWYQQRDGhgLQLISTQLRg-dKPTYEEgyk--dgFQVNRTengkISF 91  African clawed frog
AAD56906   25 VHQTPp-DLIKNIQESTDLSCSHSip-nHEFMLWYKRSENkqLQLLGYLNSk-fPYPEDSlka-kieLYGDGNn---EGK 97  channel catfish
AAG46038   20 VIQHPd-ISWSFVSQQAEMNCSHKkdvgHNQMYWYRQRPGetMSLIVYTAVg-lPPDYGGvsq--tkYTASKEky-dYGA 94  bicolor damselfish
BAB82605   24 ITQWPh-YISRFPSGSAEMHCYQNdt-dYNHMYWYRQQRGkePQLVVYLVGs-sANFEEGfk---sgFEAEIVqk-kKWS 96  bastard halibut
CAD57366   26 VKQPPvlSVCREGDASVTLRCYHDds-sYYYMFWYRQRDNn-MEMLTYSLGq-gLWEIQPpfekdvhYTMSRPel-tRST 101 rainbow trout
Feature 1                  # #                ###      
1KB5_B     78 LQVAnms--qgRTLYCTCSAApdwgasaeTLYFGSGTRLTV 116 house mouse
1KTK_E     79 LTVTsahpedsSFYICSALAGsgs--stdTQYFGPGTRLTV 117 human
1NFD_B     76 MNMSaleledsAMYFCASSLRwg-----dEQYFGPGTRLTV 111 Mus musculus
P01734     96 LEIQsseagdsALYLCASSLFgt-----sDYTFGSGTRLLV 131 house mouse
P01735     94 LHISavdpedsAVYFCASSHGqgv--sgnTLYFGEGSRLIV 132 house mouse
AAC03369   92 LEIKspkpqdqSLYLCAASDPrg----adRLYFGDGTILTV 128 African clawed frog
AAD56906   98 LTIKnlqpddsAVYFCAVGLGin----rdQAYFGDGTKLTV 134 channel catfish
AAG46038   95 LTVKdlqpedsGVYFCAVSTGgd----ydPAYFGKGTKLTV 131 bicolor damselfish
BAB82605   97 LKIPsiqekdeAVYLCAASRDsn----ydPAYFGSGTKLTV 133 bastard halibut
CAD57366  102 LEIKnlevgdgAVYYCASSRQgs----nqPAFFGNGTKLSV 138 rainbow trout

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