2CRY


Conserved Protein Domain Family
IgI_5_KIRREL3
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cd05898: IgI_5_KIRREL3 
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Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1). These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development. Neph1 and 2 may mediate axonal guidance and synapse formation in certain areas of the CNS. In the kidney they participate in the formation of the slit diaphragm.
Links
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Statistics
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PSSM-Id: 409479
Aligned: 4 rows
Threshold Bit Score: 185.155
Created: 11-Feb-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #####                                                                          
2CRY_A     13 GPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLEs--GTSg-RYTVETISTe---eGVISTLTISNIVRA 86  human
NP_998033 390 GPPIISSEPFQYAVRGERGEVKCYIASTPPPDKIVWAWKENVWEkekGTLseRYTVEQSKPsaqggAVLSTLTINNIMES 469 zebrafish
XP_423078 235 GPPIISSEVVQYAARGDRGKVECFIGSTPPPDRIAWAWKENILEa--GTLe-RYTVERTTMg---sGVLSTLTINNVMEA 308 chicken
Q96J84    391 GPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEv--GTLe-RYTVERTNSg---sGVLSTLTINNVMEA 464 human

Feature 1                             
2CRY_A     87 DFQTIYNCTAWNSFGSDTEIIRLK 110 human
NP_998033 470 DFQSTYNCTAWNSFGSGTMIISLE 493 zebrafish
XP_423078 309 DFQTHYNCTAWNSFGPGTAIIQLE 332 chicken
Q96J84    465 DFQTHYNCTAWNSFGPGTAIIQLE 488 human

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