Conserved Protein Domain Family
Ig_Pro_neuregulin-1

?
cd05895: Ig_Pro_neuregulin-1 
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
The members here are composed of the immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. NRG-1 belongs to the neuregulin gene family which is comprised of four genes. This group represents NRG-1. NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, and heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions, for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.
Statistics
?
PSSM-Id: 409476
View PSSM: cd05895
Aligned: 4 rows
Threshold Bit Score: 165.166
Threshold Setting Gi: 9297012
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
?
Aligned Rows:
  next features
Feature 1:putative Ig strand A [structural motif]
Evidence:
  • Comment:based on sequence similarity to other known I-set Ig superfamily domains.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1        #######                                                                         
Q02297        37 PRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRkn----kPQNIKIQKk-pGKSELRINKASLADSGEYM 111 human
O93383        37 PKLKEIKTQSVQEGKKLVLKCQAVSEQPSLKFRWFKGEKEIGAknkpdskPEHIKIRGk-kKSSELQISKASSADNGEYK 115 African clawed ...
Q05199        29 PKLKEMKNQEVAVGQKLVLRCETTSEYPALRFKWLKNGKEITKkn----rPENVKIPKkqkKYSELHIYRATLADAGEYA 104 chicken
NP_001258059  44 PRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRkn----kPENIKIQKk-pGKSELRINKASLADSGEYM 118 Rattus norvegicus
Feature 1                          
Q02297       112 CKVISKLGNDSASANITI 129 human
O93383       116 CMVSNQLGNDTVTVNVTI 133 African clawed frog
Q05199       105 CRVSSKLGNDSTKASVII 122 chicken
NP_001258059 119 CKVISKLGNDSASANITI 136 Rattus norvegicus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap