3U83


Conserved Protein Domain Family
IgC1_2_Nectin-1_like

?
cd05890: IgC1_2_Nectin-1_like 
Second immunoglobulin (Ig) domain of nectin-1, and similar domains; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectin-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.
Statistics
?
PSSM-Id: 143298
View PSSM: cd05890
Aligned: 4 rows
Threshold Bit Score: 189.816
Threshold Setting Gi: 47227897
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1     #######                                                                         
3U83_A    131 PTNWIEGTqavlrakkgqddkVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLA 210  human
CAG09060  129 PMTRMTLTtptiva-raqkrkMTVATCVSANGKPPSVIRWDTRLKGEPTFQETRNQNGTVTVRSNYVLIPSRETHKQKLT 207  Tetraodon nigrovi...
Q15223    146 PTNWIEGTqavlrakkgqddkVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLA 225  human
XP_417892 611 PTNRMEGTtrpliaksgrtekILVATCISSNGKPPSTVTWDTKLKGEAEFQEIRNSNGTFTVISRYRLVPSREAHRQQLM 690  chicken
Feature 1                       
3U83_A    211 CIVNYHMDRFKESLTLNV 228  human
CAG09060  208 CIVTYRNERITDSVVLNV 225  Tetraodon nigroviridis
Q15223    226 CIVNYHMDRFKESLTLNV 243  human
XP_417892 691 CVVNYQLDRFTDSITLNV 708  chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap