4FMF


Conserved Protein Domain Family
IgV_1_Nectin-1_like

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cd05886: IgV_1_Nectin-1_like 
First immunoglobulin variable (IgV) domain of nectin-1, and similar domains
The members here are composed of the first immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1 (PVRL1) or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.
Statistics
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PSSM-Id: 409469
View PSSM: cd05886
Aligned: 4 rows
Threshold Bit Score: 218.296
Threshold Setting Gi: 47227142
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 61 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to human poliovirus receptor (CD155).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ########         #########      #############                     
4FMF_A       1 QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPs------- 73   human
CAG00504    16 QTVDMDDGKSGFVDSRVDLRCRFINSSPPVKISQVTWQKLVNGSKQNVAIANPSLGVSVAPPYRDRVTFKNGavrrrtpn 95   Tetraodon nigrov...
XP_417892  496 QTVLVNDTVSGYIGTDVVLHCSFTNPLPNVKITQVTWQKVTNGTKQNVAIYNPAMGVSILPPYKERVTFRNPs------- 568  chicken
Q15223      31 QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPs------- 103  human
Feature 1         #######    ###############  #########
4FMF_A      74 fTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVM 113  human
CAG00504    96 lEDTTISFSSLRLSDEATYICEYTTFPAGNRENTVNLTVY 135  Tetraodon nigroviridis
XP_417892  569 fKDGTIQLSRLELEDEGVYICEFATFPTGNRESQLNLTVL 608  chicken
Q15223     104 fTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVM 143  human

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