Conserved Protein Domain Family
Ig3_L1-CAM

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cd05876: Ig3_L1-CAM 
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains, five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM.
Statistics
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PSSM-Id: 409460
View PSSM: cd05876
Aligned: 4 rows
Threshold Bit Score: 150.832
Threshold Setting Gi: 1171701
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
 
Feature 1:Ig strand B [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #####                                                               
1171701    244 PQTTTIALRGGSVVLECIAEGLPTPWVRWRRLNGpllp--ggvgNFNKTLRLWGVTESDDGEYECVAENGRGTARGTHSV 321  chicken
CAM60094   253 ARSSYLVLRGQTLTLECIPEGLPTPEVHWDRIDSalspnrtkklYNNRWLQIDNVLESDDGEYVCTARNSENSVKHHYTV 332  zebrafish
1705571    248 SSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGpmpadrvtyqNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV 327  human
AAH56988   247 SSSRLVALQGQSLILECIAEGFPTPTIKWLHPSDpmptdrviyqNHNKTLQLLNVGEEDDGEYTCLAENSLGSARHAYYV 326  Mus musculus
Feature 1         
1171701    322 TVE 324  chicken
CAM60094   333 TVE 335  zebrafish
1705571    328 TVE 330  human
AAH56988   327 TVE 329  Mus musculus

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