3P40


Conserved Protein Domain Family
IgI_hNeurofascin_like

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cd05875: IgI_hNeurofascin_like 
Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the first immunoglobulin (Ig)-like domain of human neurofascin (NF). NF belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and a cytoplasmic domain. NF has many alternatively spliced isoforms having different temporal expression patterns during development. NF participates in axon subcellular targeting and synapse formation, however little is known of the functions of the different isoforms. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lacks a C" strand.
Statistics
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PSSM-Id: 409459
View PSSM: cd05875
Aligned: 4 rows
Threshold Bit Score: 200.587
Threshold Setting Gi: 134085176
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #####                                                                           
3P40_A      17 PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSggrpeEYEGEYQCFA 96   human
CAM60068    42 PTIVKQSLKDYIVDPRDNIIIECEAKGNPVPTFQWRRNGKFFNVGKDPRVTMRSRSGTLEIRSSGkp--eDYEGEYQCFA 119  zebrafish
O94856      41 PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSggrpeEYEGEYQCFA 120  human
O42414      42 PTITKQSVKDYIVDPRDNIFIECEAKGNPVPTFSWTRNGKFFNVAKDPKVSMRRRSGTLVIDFHGggrpdDYEGEYQCFA 121  chicken
Feature 1                     
3P40_A      97 RNKFGTALSNRIRLQ 111  human
CAM60068   120 SNNLGTAISNKILLR 134  zebrafish
O94856     121 RNKFGTALSNRIRLQ 135  human
O42414     122 RNDYGTALSSKIHLQ 136  chicken

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