1OLZ


Conserved Protein Domain Family
Ig_Sema4D_like

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cd05873: Ig_Sema4D_like 
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Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins
The members here are composed of the immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane-bound form and/or its cleaved form.
Statistics
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PSSM-Id: 409457
View PSSM: cd05873
Aligned: 6 rows
Threshold Bit Score: 146.497
Threshold Setting Gi: 47228359
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1OLZ, human semophorin SEMA4D fragment, dimer interface defined by 3.5A distance.
    View structure with Cn3D
  • Comment:Dimer interface involves both the Sema domain and the C-terminal Ig domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #                                        #                          
1OLZ_A        538 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLkaespKYGLMgrKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 617  human
XP_418232     344 NDVRKYLFTLGNNVHLKCVPLSNLARVVWKFNGSRIqdkdsKYLLYd-GGIAIFNVTVAETGFYDCLSVEKSKAKEFFIT 422  chicken
XP_424426     545 ENSLQHTFKHGSTAELKCSQKSNLAQVVWKFRDDVLrvespKYRLLe-KALLIFNLSEGDSGVYQCLSEEKVKNKKFSQV 623  chicken
CAG07754      473 LDPLERTIWPGGNLNLSCSLPSQLAKTVWELDGKTLtp-taRVQSLr-DGLLIFHASGSDAGRYRCLSVEKSKAGLFTTT 550  Tetraodon nig...
NP_001038473  542 IEPKVRTLVLGNNIRLLCRPDSNLAQVNWNLAGKPLpfsnrKYTIYn-DAILISNASSADAGRYTCVSVEQAKGKHYTKT 620  zebrafish
Q92854        559 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLkaespKYGLMgrKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 638  human
Feature 1                 
1OLZ_A        618 VAKHVLEV 625  human
XP_418232     423 VARYALYA 430  chicken
XP_424426     624 LAKHVLEL 631  chicken
CAG07754      551 VAEYQLVG 558  Tetraodon nigroviridis
NP_001038473  621 LAIYDLHE 628  zebrafish
Q92854        639 VAKHVLEV 646  human

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